Efficacy of topical formulations containing Pimenta pseudocaryophyllus extract against UVB-induced oxidative stress and inflammation in hairless mice

Enhanced permeability of ferulic acid loaded nanoemulsion based gel through skin against UVA mediated oxidative stress

“…ROS can influence lipid peroxidation in membranes [8] which leads to the melanoma, dermatitis, ageing, inflammations and other severe problems [9]. Endogenous antioxidant capability of the skin is a major determinant in its response to oxidative stressmediated damage involving reduced level of antioxidant enzymes, including glutathione [10], superoxide dismutase, catalase, glutathione peroxidase and increased levels of thiobarbituric acid reactive substances [11]. The topical antioxidant lotions may be beneficial, but they cannot protect the skin on long-term exposure of sun rays and need to be applying frequently [12].…”

Superoxide anion-induced pain and inflammation depends on TNFα/TNFR1 signaling in mice

“…The tests were adapted to a 96-well microplate format as previously described [1]. Plantar skin samples were collected 3 h after i.pl.…”

“…BKeywords: Hyperalgesia; inflammation; oxidative stress; superoxide anion; TNFα; TNFR1 ITargeting superoxide anion and tumor necrosis factor-alpha (TNFα) alleviate pain and inflammation [1,17,22]. Depending on disease context model, TNFα sensitizes nociceptive neurons acting indirectly via prostaglandin E 2 production and directly on nociceptive neurons through the tumor necrosis factor receptor 1 (TNFR1).…”

Validation of Medicinal Herbs for Skin Aging

“…This leads to changes and often to destruction of skin structures and results in hindrance of regular function [6]. An imbalance between ROS and endogenous antioxidant systems, such as reduced GSH, results in a severe decrease of its antioxidant content and in a striking formation of active oxygen intermediates as a result [5].…”

“…ROS formed as a result of UV irradiation may oxidize and damage cellular lipids, proteins, and deoxyribonucleic acid (DNA). This leads to changes and often to obliteration of skin structures and can result in the hindrance of its regular function [6]. A small amount of UV radiation is required for the production of vitamin D; however, extensive exposure to the sun increases the risk of developing sunburn, accelerates skin aging, and causes wrinkles and several malignant skin cancers [7].…”