2021
DOI: 10.1002/lary.29688
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Efficacy of Topical Epinephrine in Tympanoplasty

Abstract: Objectives/Hypothesis: To compare the hemostatic effects of commonly used concentrations of topical epinephrine in tympanoplasty.Study Design: Prospective, randomized, controlled clinical trial. Methods: Patients undergoing tympanoplasty were randomized to receive topical epinephrine at 1:1,000 or 1:10,000. With the investigators blinded, hemostasis was assessed with a modified Boezaart scale. Vasoconstriction was measured by laser Doppler. Blood pressure and pulse were tracked.Results: Thirty patients, 4 to 8… Show more

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Cited by 2 publications
(2 citation statements)
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“…However, the 4 mm-diameter endoscope occupies a certain amount of space, which frequently requires the treatment of a large area of mucosa and the excision of one or both middle turbinates during the nasal phase. Hemostasis of the mucosa should reach the highest grade in otolaryngology, known as Boezart grade 1 ( 16 ). Extensive intervention in the nasal mucosa and excision of the middle turbinate have been documented to frequently cause postoperative nasal discomfort, requiring periodic clearance of nasal crusts every 2 to 3 weeks ( 3 , 17 ).…”
Section: Discussionmentioning
confidence: 99%
“…However, the 4 mm-diameter endoscope occupies a certain amount of space, which frequently requires the treatment of a large area of mucosa and the excision of one or both middle turbinates during the nasal phase. Hemostasis of the mucosa should reach the highest grade in otolaryngology, known as Boezart grade 1 ( 16 ). Extensive intervention in the nasal mucosa and excision of the middle turbinate have been documented to frequently cause postoperative nasal discomfort, requiring periodic clearance of nasal crusts every 2 to 3 weeks ( 3 , 17 ).…”
Section: Discussionmentioning
confidence: 99%
“…Even these very low concentrations can impair inner ear perfusion though not causing any relevant clinical complications [3,4]. Besides that epinephrine can be applied superficially on the bleeding tissue in a high concentration (1:1.000) to diminish or stop bleeding in situations when surgical hemostatic methods fail or are technically not feasible, such es endoscopic or microscopic ear surgery [5][6][7][8]. It is believed that this may have an effect on local circulation as well as on pain perception, this phenomenon has not been investigated yet.…”
Section: Introductionmentioning
confidence: 99%