Efficacy of topical acidified aliphatic ester for treatment of axillary osmidrosis by rebalancing skin microecology

Abstract

This study investigated the mechanism and efficacy of topical acidified aliphatic ester for treatment of axillary osmidrosis (AO). A total of 32 AO patients were enrolled in this study. In the initial pilot study, 20 patients were double-blindly, randomly divided into acidified aliphatic ester or aliphatic ester treatment groups, followed by efficacy evaluation after 4 weeks. Then, all patients (n = 32) were treated with topical acidified aliphatic ester for 16 weeks. Efficacy was evaluated at every 4 weeks, and at 3-and 6-month follow-ups. Changes of pH values and microecology at targeting sites were analyzed. In the first cohort (n = 20) of pilot study, acidified aliphatic ester showed significantly higher curative rate (60% vs 10%, P < .05) and effective rate (90% vs 30%; P < .05) than aliphatic ester. For the next 16 weeks, 25 of 32 cases completed treatment. Curative rate showed gradual and significant increases from 64% to 96% during the treatment courses (P = .001); it slightly but insignificantly decreased at 3-and 6-month follow-ups. Abundance of Corynebacterium and Anaerobic bacteria decreased while Staphylococcus increased after treatments. Axillary pH values negatively correlated with Staphylococcus abundance (r = −.40, P = .01) and positively with Corynebacterium abundance (r = .64, P = .01). We concluded that topical acidified aliphatic ester could effectively alleviate conditions of AO patients by reducing value of axillary pH and rebalancing axillary microecology.

Treatment of Axillary Osmidrosis by Rebalancing Skin Microecology With Lactobacillus bulgaricus

“…Therefore, our results demonstrate that L. bulgaricus treatment can effectively reduce the severity of AO by decreasing the abundance of Corynebacterium . Other scholars (Zeng et al, 2021 ) have hypothesized that Corynebacterium may be pathogenic, but Staphylococcus may be probiotic for AO, indicating that Corynebacterium is a harmful bacterium and Staphylococcus may be a protective bacterium, which is inconsistent with our findings. The addition of L. bulgaricu in our experiment might lead to the insignificant increase in the abundance of Staphylococcus .…”

Power‐assisted rotary cutter with negative pressure suction through small incision for axillary osmidrosis

“…Women have obvious onset during menstruation and pregnancy, suggesting that axillary osmidrosis is related to the levels of growth hormone and sex hormone. 12 Therefore, nonsurgical treatment is usually adopted for underage axillary osmidrosis patients, and surgery is recommended for patients in adulthood. 5 At present, the pathogenesis of axillary osmidrosis is not completely clear, and most scholars believe that it is related to abnormal secretion of sweat.…”

“…Axillary osmidrosis tends to occur in puberty and after puberty, and tends to be stable in adulthood. Women have obvious onset during menstruation and pregnancy, suggesting that axillary osmidrosis is related to the levels of growth hormone and sex hormone 12 . Therefore, nonsurgical treatment is usually adopted for underage axillary osmidrosis patients, and surgery is recommended for patients in adulthood 5 …”