Efficacy of Tinospora cordifolia in allergic rhinitis

Badar, Vandana; Thawani, Vijay; Wakode, PT; Shrivastava, Mayuri; Gharpure, Kunda; Hingorani, Lal; Khiyani, Rakesh

doi:10.1016/j.jep.2004.09.034

Cited by 84 publications

(51 citation statements)

References 13 publications

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“…After placebo, decrease in eosinophil and neutrophil count was marginal and goblet cells were present. TC significantly decreased all symptoms of allergic rhinitis 36 .…”

Section: Syzygium Cuminimentioning

confidence: 89%

Untitled

2017

IJPSR

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Allergic Rhinitis (AR) represents a common and serious health problem in pediatric age group in term of outpatient visit. The chronic nature of disease and its association with other comorbid conditions like asthma, eczema etc. has shown significant negative impact on quality of life, school performance and cognitive functioning in children which has influenced many parents to seek alternative therapies. Moreover there is a growing concern of long term use of dose related side effects of corticosteroids, antihistaminic etc. Considering etiopatho genesis of AR, Ayurvedic herbal drugs possessing properties of antihistaminic, mast cell stabilizer and immunomodulators, alone or in combination can show positive effects in relieving the symptoms of AR. Thus in this review paper, an attempt has been made in this direction to prepare a comprehensive list of herbal drugs with above aforementioned properties that can help in the management of AR in pediatric age group with better clinical efficacy and safety profile.

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“…After placebo, decrease in eosinophil and neutrophil count was marginal and goblet cells were present. TC significantly decreased all symptoms of allergic rhinitis 36 .…”

Section: Syzygium Cuminimentioning

confidence: 89%

Untitled

2017

IJPSR

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“…Thus Tinospora cordifolia significantly decreased all symptoms of allergic rhinitis and was well tolerated (Badar et al, 2005).…”

Section: Anti Allergic Activitymentioning

confidence: 91%

Medicinal use of the unique plant Tinospora Cordifolia: evidence from the traditional medicine and recent research

Khan

Haque

Chowdhury

2017

Asian J. Med. Biol. Res

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Tinospora cordifolia is commonly known as Gulancha in Bangladesh is belongs to Menispermaceae family and it is also available all over the world. It is widely used as a unique ingredient of various natural medicine and traditionally use for numerous aliment like fever, vomiting, diabetes, jaundice, anaemia, polyuria and skin diseases etc. It has hypoglycemic, antipyretic, anti-allergic, Antineoplastic, anti inflammatory, antioxidant, and immuno modulatory properties. A variety of constituents have been isolated from different parts of Tinospora cordifolia, mainly contains alkaloids like Aporphine alkaloids, clerodane diterpenes, berberine, palmatine, tembertarine, tinosporin, magniflorine, choline, Berberine, Palmatine, Tembetarine, Magnoflorine Choline, Tinosporin etc. and Glycoside like Tinocordiside, Tinocordifolioside, steroids, essential oils, mixture of fatty acids and polysaccharides are found in Gulancha plant. This review presents a detailed survey of the literature on traditional and modern knowledge of Tinospora cordifolia for health benefit.

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“…A small clinical study showed that taking a specific extract (Tinofend, Verdue Sciences) at 300 mg three times daily decreased allergic rhinitis symptoms such as sneezing, nasal itching, and nasal discharge [78]. Tinospora is often used as a whole plant extract that contains several bioactive compounds including the bitter diterpenoids columbin, chasmanthin and palmarin.…”

Section: Immunomodulatory Compoundsmentioning

confidence: 99%

The Potential of Natural Products as Effective Treatments for Allergic Inflammation: Implications for Allergic Rhinitis

Kulka¹

2009

CTMC

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Abstract:The impact of natural products on human health has been enormous, and the study of natural products continues to influence research in the fields of chemistry, biology, and ecology. Historically, the majority of our medicines originate from natural products and their synthetic derivatives, many of which have taught us valuable lessons about biology. While advances in synthetic and combinatorial chemistry have given rise to notable successes in the development of new drugs, the perceived value of natural products in the treatment of allergic disease has yet to be fully explored. The immune system is a highly complex, intricately regulated group of cells whose integrated function is essential to health. Cells of the immune system may interact in a cell-cell manner and may also respond to intercellular messages including hormones, cytokines, and effector molecules produced by various cells. These effector molecules include histamine, kinins, leukotrienes, prostaglandins, and serotonin. The immune system can be modified by diet, pharmacologic agents, environmental pollutants, and naturally occurring food chemicals, such as vitamins and flavonoids. Allergic inflammation is mediated by several types of immune cells all of which can be effected by these naturally occurring bioactive compounds but this review will focus on mast cells and their mediators since these cells are the focal point of allergic reactions such as allergic rhinitis. The molecular mechanisms and scientific validity of some herbal remedies currently used clinically in the treatment of allergic rhinitis will be explored.

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Efficacy of Tinospora cordifolia in allergic rhinitis

Cited by 84 publications

References 13 publications

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Medicinal use of the unique plant Tinospora Cordifolia: evidence from the traditional medicine and recent research

The Potential of Natural Products as Effective Treatments for Allergic Inflammation: Implications for Allergic Rhinitis

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