Efficacy of the supramolecular complex of Fenbendazole against nematodiasis in sheep

Abstract

Objective of research: to study the anthelmintic efficacy of the supramolecular complex of
 Fenbendazole used against different nematode species in sheep
 Materials and methods: Experiments were carried out on young sheep spontaneously
 infected with gastrointestinal strongylates (48 head), Dictyocaulus filaria (42 head), Strongyloides
 papillosus (21 head) и Trichocephalus ovis (24 head). In each helminthiasis, the supramolecular
 complex of Fenbendazole was given once orally to sheep from various groups at the dose of 3,0;
 2,0 and 1,0 mg a.i./kg in comparison with the base preparation Fenbendazole at the doses of 1,0
 and 3,0 mg/kg. Sheep which didn’t receive the drug served as controls.
 The efficacy of drugs was evaluated before and 18 days after dehelmintization according to the
 results of coprolarvoscopic examination by flotation and G. Baermann methods. The registration
 of drug activity was performed using the «control test».
 Results and discussion: Anthelmintic efficacy was studied and a therapeutic dose for the
 supramolecular complex of Fenbendazole produced by chemical mechanical technology using
 the Drug Delivery System was determined. In gastrointestinal strongylatoses the supramolecular
 complex against D. filaria. at the doses of 3,0; 2,0 and 1,0 mg a.i./kg showed the efficacy of 100;
 93,4 and 78% , respectively.
 The efficacy of supramolecular complex at the dose of 3,0 mg/kg against S. papillosus was
 100 %, and against T. ovis - 98,3 % at 10–13% efficacy of the base preparation Fenbendazole at
 the dose of 1,0 mg/kg. The therapeutic dose for the supramolecular complex at main nematodiasis
 in sheep was 3,0 mg a.i./kg.