Efficacy of the herbal formula of Foeniculum vulgare and Rosa damascena on elderly patients with functional constipation: A double-blind randomized controlled trial

Azimi, Maryam; Niayesh, Hanieh; Raisezadeh, Mahboobeh; Shahraki, Sedigheh Khodabandeh

doi:10.1016/j.joim.2022.03.001

Cited by 3 publications

(2 citation statements)

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“…[2] According to a recent Indian survey, nearly 16.8% of India's adult population suffers from constipation. [3] Constipation is associated with fecal incontinence and impaction, hemorrhoids, fissures, urinary incontinence, and cardiovascular complications, [4] all of which have a significant impact on patients' quality of life (QoL). The risk factors for constipation include age, gender, depression, physical inactivity, certain medications, and diseases.…”

Section: Introductionmentioning

confidence: 99%

“…[5] Nonpharmacologic treatments, such as lifestyle interventions (e.g., exercise, a high-fiber diet, and high fluid intake), are generally not tolerated by older patients because of their limited motility, polypharmacy, and other underlying medical conditions. [4] Various drugs, including bulking agents, stimulants, stool softeners, and osmotic agents, are used in clinical practice depending on the severity and chronicity of the condition. [6,7] Even though conventional treatment is well established and safe, it does not provide satisfactory improvement for many patients.…”

Section: Introductionmentioning

confidence: 99%

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The Efficacy and Safety of an Ayurvedic Petsaffa Formulation in Subjects with Constipation: An Open-Label, Non-Randomized Clinical Study

Kimtata¹,

Gupta²,

Singh³

et al. 2023

Int J Ayu Pharm Res

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Constipation is a common gastrointestinal complaint among 16% of the world's population. Several conventional treatments are recommended; however, these sometimes do not provide satisfactory results for many patients or cause unpleasant side effects. In this context, Ayurvedic medicine can be an alternative, cost-effective and satisfactory treatment for constipation. Hence, this clinical study aimed to evaluate the efficacy and safety of an Ayurvedic PetSaffa formulation in subjects with functional constipation. Design, Setting, Participants and Intervention: This open-label, non-randomized clinical study was conducted to evaluate the safety and efficacy of an Ayurvedic PetSaffa formulation in healthy volunteers with functional constipation. Subjects were selected based on inclusion and exclusion criteria. Participants received PetSaffa granules for 21 days. Outcome parameters of the study, including frequency of bowel movements, constipation score, constipation symptoms, gas, acidity, and serum level of SGPT, were evaluated at screening and after 21 days of treatment. Results: A total of 120 participants completed the 21-day treatment. At the end of the treatment period, all clinical outcomes, including frequency of bowel movement and constipation score, were significantly (p<0.001) improved. The analysis of constipation symptoms' frequencies and severity also significantly (p<0.001) improved without any significant adverse effects. Additionally, PetSaffa granules also reduced gas and acid symptoms. As part of the safety study, serum levels of SGPT were within the normal range before and after treatment. Conclusion: The study intervention, PetSaffa granules, significantly improved bowel movements, gas and acidity symptoms without causing any adverse effects. Therefore, the Ayurvedic PetSaffa granules are a clinically effective and safe alternative for the treatment of functional constipation.

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Section: Introductionmentioning

confidence: 99%