Efficacy of the Enquiring About Tolerance (EAT) study among infants at high risk of developing food allergy

Abstract

Nonwhite ethnicity: • In general a nonsignificant reduc on in food allergy in nonwhite EIG compared with nonwhite SIG Sensi zed: (IgE ≥0.1 kU/l to one or more foods) • EIG 19.2% versus SIG 34.2% developed any food allergy* Visible eczema: (moderate SCORAD 15 to <40) • EIG 22.6% versus SIG 46.7% developed any food allergy* • EIG 16.1% versus SIG 43.3% developed an egg allergy* Sensi zed: (IgE ≥0.1 kU/l to egg) • EIG 20.0% versus SIG 48.6% developed an egg allergy* *p<0.05 EIG: Early Introduc on Group SIG: Standard Introduc on Group Distribu on of enrollment (3 months of age) risk factors associated with a higher risk of developing a food allergy: Sensi za on (IgE ≥ 0.1 kU/l to one or more foods), visible eczema (any) at the clinic visit and nonwhite ethnicity (n=1170) Nonwhite Sensi zed

Factors influencing adherence in a trial of early introduction of allergenic food

“…The group of infants with early food-specific IgE sensitization accounted for 69% of the food allergy cases that developed in the EAT study. We have shown that the EAT study early introduction intervention was effective in an intention-to-treat analysis of this high-risk population 13 …”

“…Enrollment sensitization was not associated with overall or food-specific adherence. Furthermore, the EAT intervention was effective in an intention-to-treat analysis in the enrollment-sensitized EIG infants 13 …”

Recent advances in the management of nut allergy

“… 152 This finding was sequentially supported by the results from the EAT (Enquiring about tolerance) study in the per protocol group and in children with positive sIgE >0.1kU/L. 153 , 154 In addition, as the follow up LEAP-On Study showed, this protective effect remained beyond time of intervention, and 1 year of peanut avoidance was not associated with an increase in peanut allergy. 155 …”

Epicutaneous sensitization in the development of food allergy: What is the evidence and how can this be prevented?

“…Interest in restoring the skin barrier to prevent AD and FA has gained ground in recent years. Oral tolerance induction has offered a completely new strategy for the prevention of FA; results are compelling for PA 24 and moderate for egg allergy 25 . If this strategy were to work for other food allergens, it would require the introduction of multiple food allergens very early on in life.…”