Efficacy of the eHealth application Oncokompas, facilitating incurably ill cancer patients to self-manage their palliative care needs: A randomized controlled trial

Schuit, Anouk S.; Holtmaat, Karen; Lissenberg‐Witte, Birgit I.; Eerenstein, Simone E. J.; Zijlstra, Josée M.; Eeltink, Corien; Becker-Commissaris, Annemarie; Zuylen, Lia van; Linde, Myra E. van; Oordt, Catharina W. Menke-van der Houven van; Sommeijer, Dirkje W.; Verbeek, Nol; Bosscha, K.; Tewarie, Rishi Nandoe; Sedee, Robert-Jan; Bree, Remco de; Graeff, Alexander de; Vos, Filip De; Cuijpers, Pim; Leeuw, Irma M. Verdonck‐de

doi:10.1016/j.lanepe.2022.100390

Cited by 16 publications

(29 citation statements)

References 34 publications

(44 reference statements)

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“…Detailed information on the study design can be found in previous publications [ 10 , 19 ]. Data on the cost-utility of Oncokompas were collected alongside an RCT to determine the efficacy of Oncokompas among adult patients (≥18 years) with incurable cancer (i.e., not having curative treatment options) [ 10 ].…”

Section: Methodsmentioning

confidence: 99%

“…Oncokompas is based on the stepped care principle, supporting patients to take actions to deal with their symptoms by themselves, only with professional guidance if needed. Recently, a randomized controlled trial (RCT) was conducted to determine the efficacy of Oncokompas among patients with incurable cancer, in which no significant improvements were found in patient activation (i.e., patients’ skills, knowledge, and confidence to manage their disease [ 9 ]), general self-efficacy and health-related quality of life (HRQOL) [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

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Cost-Utility of the eHealth Application ‘Oncokompas’, Supporting Incurably Ill Cancer Patients to Self-Manage Their Cancer-Related Symptoms: Results of a Randomized Controlled Trial

et al. 2022

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Evidence on the cost-effectiveness of eHealth in palliative care is scarce. Oncokompas, a fully automated behavioral intervention technology, aims to support self-management in cancer patients. This study aimed to assess the cost-utility of the eHealth application Oncokompas among incurably ill cancer patients, compared to care as usual. In this randomized controlled trial, patients were randomized into the intervention group (access to Oncokompas) or the waiting-list control group (access after three months). Healthcare costs, productivity losses, and health status were measured at baseline and three months. Intervention costs were also taken into account. Non-parametric bootstrapping with 5000 replications was used to obtain 95% confidence intervals around the incremental costs and quality-adjusted life years (QALYs). A probabilistic approach was used because of the skewness of cost data. Altogether, 138 patients completed the baseline questionnaire and were randomly assigned to the intervention group (69) or the control group (69). In the base case analysis, mean total costs and mean total effects were non-significantly lower in the intervention group (−€806 and −0.01 QALYs). The probability that the intervention was more effective and less costly was 4%, whereas the probability of being less effective and less costly was 74%. Among patients with incurable cancer, Oncokompas does not impact incremental costs and seems slightly less effective in terms of QALYs, compared to care as usual. Future research on the costs of eHealth in palliative cancer care is warranted to assess the generalizability of the findings of this study.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Cost-Utility of the eHealth Application ‘Oncokompas’, Supporting Incurably Ill Cancer Patients to Self-Manage Their Cancer-Related Symptoms: Results of a Randomized Controlled Trial

et al. 2022

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“…In this issue of The Lancet Regional Health – Europe , Schuit and colleagues 3 conducted a randomised controlled trial in 138 incurably ill cancer patients with a life expectancy of at least three months to determine the efficacy of Oncokompas compared to care as usual on the patient activation, general self-efficacy, and HRQoL. Similar to the trial in cancer survivors, 1 this study 3 failed to show significant differences over time between the intervention and control group for patient activation and general self-efficacy. Moreover, this study also failed to show an impact on HRQoL aspects, including the symptom burden.…”

mentioning

confidence: 99%

“…The trial 3 contributes to the knowledge on the effects and usage of behavioural intervention technologies in palliative cancer care. The currently available results in both cancer survivors and incurably ill cancer patients suggest that this online self-management tool, on group level, is less valuable as expected.…”

mentioning

confidence: 99%

“…those with lower self-efficacy, and higher personal control and health literacy. 2 It could be questioned whether the cognitive status of the patients in the trial 3 also played a role in the lack of efficacy of the intervention. About one third of the patients had a brain tumour and it is known that up to 90% of patients with primary brain tumours or brain metastases from systemic cancer have cognitive deficits already at diagnosis.…”

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confidence: 99%

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Evaluating the lack of impact of the e-health application Oncokompas on outcomes in incurably ill cancer patients

Dirven

Taphoorn

2022

The Lancet Regional Health - Europe

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Electronic health intervention to manage symptoms of immunotherapy in patients with cancer (SOFIA): Results from a randomized controlled pilot trial

Sauer,

Zschäbitz,

Krauss

et al. 2024

Cancer

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BackgroundFor patients receiving immune checkpoint inhibitors, early detection of immune‐related adverse events (irAEs) is critical for one’s safety. To this end, a smartphone app (SOFIA) was developed that featured the assessment of electronic patient‐reported outcomes (ePROs) focusing on irAEs as well as a set of comprehensive supportive information. Its feasibility and preliminary efficacy were evaluated in a randomized controlled trial (RCT).MethodsPatients who received immune checkpoint inhibition therapy were randomly assigned to an intervention group (IG) or a control group (CG; care as usual). During the 12‐week intervention period, IG patients used SOFIA to report twice weekly ePROs and receive cancer‐ and immunotherapy‐relevant contents. Before a patient’s next clinical visit, the physician in charge was given the ePRO reports. The primary objective was to test the feasibility of SOFIA. Furthermore, the preliminary efficacy of SOFIA for health‐related quality of life (HRQOL), psychosocial outcomes, and medical data was examined. Clinical outcomes were assessed at baseline (T0), post‐intervention (T1), and a 3‐month follow‐up (T2).ResultsSeventy‐one patients were randomized to the IG (n = 34) or the CG (n = 37). SOFIA showed high feasibility and acceptance. At T1, patients in the IG reported significantly better HRQOL and role functioning and less depression, distress, and appetite loss. No significant differences were revealed regarding medical data, the utilization of supportive care services, or survival.ConclusionsSOFIA showed high feasibility and acceptance and improved HRQOL and psychosocial outcomes. These results suggest further evaluation of efficacy in a large‐scale confirmatory multicenter RCT.

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Efficacy of the eHealth application Oncokompas, facilitating incurably ill cancer patients to self-manage their palliative care needs: A randomized controlled trial

Cited by 16 publications

References 34 publications

Cost-Utility of the eHealth Application ‘Oncokompas’, Supporting Incurably Ill Cancer Patients to Self-Manage Their Cancer-Related Symptoms: Results of a Randomized Controlled Trial

Cost-Utility of the eHealth Application ‘Oncokompas’, Supporting Incurably Ill Cancer Patients to Self-Manage Their Cancer-Related Symptoms: Results of a Randomized Controlled Trial

Evaluating the lack of impact of the e-health application Oncokompas on outcomes in incurably ill cancer patients

Electronic health intervention to manage symptoms of immunotherapy in patients with cancer (SOFIA): Results from a randomized controlled pilot trial

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