Efficacy of the Complementary and Alternative Therapies for the Management of Psychological Symptoms of Menopause: A Systematic Review of Randomized Controlled Trials

Mehrnoush, Vahid; Darsareh, Fatemeh; Roozbeh, Nasibeh; Ziraeie, Avan

doi:10.6118/jmm.21022

Cited by 15 publications

(13 citation statements)

References 66 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In conclusion, our ndings showed that soy peptides attenuate aggression, hyperactivity, and cognitive dysfunction in mice by preventing neuronal abnormalities and also affect the microbiota composition. Accumulating evidence indicates that long-term dietary supplementation has bene cial effects on cellular functions and is nearly as effective as medication for mental health without adverse effects 59 . Considering that soy peptides have a preventive effect on age-related cognitive decline by modulating synaptic plasticity-associated proteins 34 , daily intake of soy peptides may be useful in preventing progressive deterioration of synaptic function caused by aging and juvenile chronic stress.…”

Section: Discussionmentioning

confidence: 99%

Chronic ingestion of soy peptide supplementation reduces aggressive behavior and abnormal fear memory caused by juvenile social isolation

Tamura

Miyazaki

Kawamura

et al. 2023

Preprint

View full text Add to dashboard Cite

Juvenile loneliness is a risk factor for psychopathology in later life. Deprivation of early social experience due to peer rejection has a detrimental impact on emotional and cognitive brain function in adulthood. Accumulating evidence indicates that soy peptides have many positive effects on higher brain function in rodents and humans. However, the effects of soy peptide use on juvenile social isolation are unknown. Here, we demonstrated that soy peptides prevented the deterioration of behavioral and cellular functions resulting from juvenile socially-isolated rearing. We found that prolonged social isolation post-weaning in male C57BL/6J mice resulted in higher aggression and impulsivity and fear memory deficits at 7 weeks of age, and that these behavioral abnormalities, except impulsivity, were mitigated by ingestion of soy peptides. Furthermore, we found that daily intake of soy peptides caused upregulation of postsynaptic density 95 in the medial prefrontal cortex, phosphorylation of the cyclic adenosine monophosphate response element binding protein in the hippocampus of socially isolated mice, and altered the microbiota composition. These results suggest that soy peptides have protective effects against juvenile social isolation-induced behavioral deficits via synaptic maturation and cellular functionalization.

show abstract

Section: Discussionmentioning

confidence: 99%

Chronic ingestion of soy peptide supplementation reduces aggressive behavior and abnormal fear memory caused by juvenile social isolation

Tamura

Miyazaki

Kawamura

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

“…A survey of epidemiology in China showed that perimenopausal women experienced anxiety in 81.58%, mild to moderate anxiety in 68.42%, depression in 85.09%, and mild to moderate depression in 73.68% ( 41 ). Mehrnoush et al ( 42 ) showed that menopause is not a high-risk period for mental illness but causes psychological problems, the most common of which are anxiety and depression, which impair their ability to cope with events in daily life and work, and reduce the quality of life of women. Herson et al ( 43 ) have shown that women not only have an increased risk of depression and anxiety during the perimenopausal and menopausal transition (MT) periods, but also experience higher severity of depressive symptoms during the perimenopausal period compared with before and after menopause.…”

Section: Discussionmentioning

confidence: 99%

Effects of aerobics training on anxiety, depression and sleep quality in perimenopausal women

2022

View full text Add to dashboard Cite

ObjectiveTo investigate the effect of aerobics training on anxiety, depression and sleep disturbance in perimenopausal women.Materials and methodsA total of 289 perimenopausal women with anxiety, depression or sleep disorder in Lishi district of Luliang city were treated with aerobics training. Self-rating anxiety scale, self-rating depression scale and Pittsburgh sleep scale were used to investigate the anxiety, depression and sleep status of perimenopausal women before and after intervention.ResultsAfter aerobics training, the scores of self-rating anxiety scale, self-rating depression scale and Pittsburgh sleep questionnaire were 48.26 ± 6.47, 50.27 ± 6.54 and 10.64 ± 4.38, respectively. The levels of anxiety, depression and sleep disorder in 289 subjects were significantly lower than those before intervention (t = 3.865, 4.541, 5.596, P < 0.01). The remission rate of symptoms was significantly different in subjects with different frequency of spontaneous practice (P < 0.01), and the higher the number of spontaneous practice, the higher the remission rate of anxiety, depression and sleep disorders in subjects (P < 0.01).Conclusionaerobics training can effectively improve the anxiety and depression of perimenopausal women, improve sleep quality, the more frequency of practice, the more obvious the effect. It can be used as an intervention to improve the mental health level of perimenopausal women in terms of anxiety, depression and sleep quality in clinical promotion.

show abstract

“…Other botanical supplements. Several other botanicals have been trialled for treating depressive symptoms during menopause (Johnson et al, 2019;Mehrnoush et al, 2021). However, the available evidence was typically limited to a single RCT, and not all interventions reported a significant improvement in depressive or psychological symptoms.…”

Section: Food and Botanical Supplementsmentioning

confidence: 99%

The role of diet in managing menopausal symptoms: A narrative review

et al. 2023

View full text Add to dashboard Cite

Menopause is a natural stage that occurs when women stop menstruating, during which many women experience physical and psychological symptoms that can affect their quality of life and ability to work. Dietary modifications and food supplements may be explored by some women as alternatives to hormone replacement therapy, although existing reviews and expert position statements have given this limited consideration. This narrative review summarises the current evidence for dietary patterns, and botanical and food supplements, in the management of common menopausal symptoms, including vasomotor symptoms (VMS; hot flushes; night sweats), changes in bodyweight and composition, psychological symptoms (depression; anxiety; cognitive changes), sleep disturbances, joint pain, skin changes and urogenital symptoms. Soy isoflavones may reduce the frequency and/or severity of VMS, although results are inconsistent, and it is unclear whether dietary and supplemental sources have comparable effects. Adopting a healthier dietary pattern may support a healthy bodyweight and benefit VMS. However, evidence suggesting dietary patterns may benefit depression, anxiety, and cognition remains largely observational. While some botanicals, such as black cohosh and St John's Wort, have been reported in some studies to alleviate symptoms (such as VMS and depression), these are not currently recommended due to uncertainty about the appropriate dose and preparation, and potential safety concerns. Evidence for other symptoms is currently too limited to draw conclusions. While further trials at different menopausal stages are needed, adopting a healthier dietary pattern in accordance with dietary guidelines is likely to help support women's health before, during and after the menopausal transition.

show abstract

Efficacy of the Complementary and Alternative Therapies for the Management of Psychological Symptoms of Menopause: A Systematic Review of Randomized Controlled Trials

Cited by 15 publications

References 66 publications

Chronic ingestion of soy peptide supplementation reduces aggressive behavior and abnormal fear memory caused by juvenile social isolation

Chronic ingestion of soy peptide supplementation reduces aggressive behavior and abnormal fear memory caused by juvenile social isolation

Effects of aerobics training on anxiety, depression and sleep quality in perimenopausal women

The role of diet in managing menopausal symptoms: A narrative review

Contact Info

Product

Resources

About