Efficacy of the combined use of a facial cleanser and moisturizers for the care of mild acne patients with sensitive skin

Abstract

Acne is a common skin disease that involves the seborrheic area of the face and results from the obstruction of hair follicles followed by inflammation. Careful face washing helps to improve and prevent acne; however, intensive washing has a risk of inducing skin barrier impairment and dry skin, especially in sensitive skin. We hypothesized that skin care combining mild skin cleansing and intensive moisturizing ("combination skin care") may be effective in the care of acne in subjects with dry skin and/or sensitive skin. We developed a combination skin care with a weakly acidic foaming facial skin cleanser based on a mild detergent, an aqueous lotion with eucalyptus extract and a moisturizing gel containing pseudo-ceramide and eucalyptus extract. To optimize an ideal facial skin care system for mild acne on sensitive skin, we performed a 4-week clinical trial with 29 post-adolescent Japanese women with mild acne with dry and sensitive skin. The acne significantly decreased after this trial accompanied by the improvement of dry skin, a significantly increased endogenous ceramide level in the stratum corneum and an elongated alkyl chain length of the non-hydroxy acyl sphingosine type ceramide. No adverse events due to the test samples were observed. Based on diagnosis by a dermatologist, 97% of the subjects found the combination skin care to be "useful" or "slightly useful". Based on these findings, the combined use of a facial skin cleanser and moisturizers is safe and effective for the care of acne in post-adolescent Japanese women with sensitive skin.

Assessment of the efficacy of a new complex antisensitive skin cream

“…The treatment of sensitive skin is challenging and generally based on continuous and topical application of antisensitive moisturizing tolerance extreme product that improves skin features associated with itching, stinging, dryness, tightness, burning, or pain . To maintain a healthy skin, it is recommended to hydrate and protect it.…”

The role of topical dermocosmetics in acne vulgaris

“…A ‘combination skin care’ including an acidic foaming facial skin cleanser, an aqueous lotion with eucalyptus extract and a moisturizing gel containing pseudo‐ceramide and eucalyptus extract proved to be effective in 4‐week non‐comparative study among 29 postadolescent Japanese women with mild acne associated with dry and sensitive skin. The significant decrease in acne as well as improvement of dry skin was achieved …”

Clinical significance of neutrophil gelatinase‐associated lipocalin and galectin‐7 in tape‐stripped stratum corneum of acne vulgaris

“…All patients with AV were under treatment with a topical preparation, which could have led to excessive face washing to rinse the ointment and/or cream off and consequently development of the dry skin . Moist care may also be required for the treatment of AV …”

“…13 Moist care may also be required for the treatment of AV. 14 The tape-stripping method allowed us to obtain SC samples non-invasively and quickly from the skin lesions of patients.…”