Efficacy of the biomaterials 3 wt%-nanostrontium-hydroxyapatite-enhanced calcium phosphate cement (nanoSr-CPC) and nanoSr-CPC-incorporated simvastatin-loaded poly(lactic- co -glycolic-acid) microspheres in osteogenesis improvement: An explorative multi-phase experimental in vitro/vivo study

Masaeli, Reza; Kashi, Tahereh Sadat Jafarzadeh; Dinarvand, Rassoul; Rakhshan, Vahid; Shahoon, Hossein; Hooshmand, Behzad; Abbas, Fatemeh Mashhadi; Raz, Majid; Rajabnejad, Alireza; Eslami, Hossein; Khoshroo, Kimia; Tahriri, Mohammadreza; Tayebi, Lobat

doi:10.1016/j.msec.2016.06.033

Cited by 38 publications

(11 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In this regard, it has been reported that ceramic particles such as bioglass and calcium phosphates [27] have been chiefly used as additives to enhance the poor mechanical properties of PLGA. Such PLGA-based composite scaffolds can be employed as the bone substitute materials and injectable pastes to fill defects because of their fascinating biocompatibility and osteoconductivity properties [28]. Recently, nanocomposites of TiO 2 hve drawn considerable attention in biomedical applications because of their effect on mechanical properties and bioactivity [29][30][31].…”

Section: Introductionmentioning

confidence: 99%

Development of 3D-printed PLGA/TiO2 nanocomposite scaffolds for bone tissue engineering applications

Rasoulianboroujeni

Fahimipour

Shah

et al. 2019

Materials Science and Engineering: C

103

View full text Add to dashboard Cite

Porous scaffolds were 3D-printed using poly lactic-co-glycolic acid (PLGA)/TiO 2 composite (10:1 weight ratio) for bone tissue engineering applications. Addition of TiO 2 nanoparticles improved the compressive modulus of scaffolds. Differential scanning calorimetry (DSC) and thermogravimetric analysis (TGA) revealed an increase in both glass transition temperature and thermal decomposition onset of the composite compared to pure PLGA. Furthermore, addition of TiO 2 was found to enhance the wettability of the surface evidenced by reducing the contact angle from 90.5 ± 3.2 to 79.8 ± 2.4 which in favor of cellular attachment and activity. The obtained results revealed that PLGA/TiO 2 scaffolds significantly improved osteoblast proliferation compared to pure PLGA (P < 0.05). Furthermore, osteoblasts cultured on PLGA/TiO 2 nanocomposite represented significantly higher ALP activity and improved calcium secretion compared to pure PLGA scaffolds (p < 0.05).

show abstract

Section: Introductionmentioning

confidence: 99%

Development of 3D-printed PLGA/TiO2 nanocomposite scaffolds for bone tissue engineering applications

Rasoulianboroujeni

Fahimipour

Shah

et al. 2019

Materials Science and Engineering: C

103

View full text Add to dashboard Cite

show abstract

“…Consequently, studies are continuously being developed to achieve appropriate drug delivery systems to enhance in-vivo curcumin stability. Some of these efforts have based on the use of polymer nanospheres of poly (DL-lactide [41,42] and (NIDAM-NVP-(PEG-A)) copolymers [43] as carriers, but also the encapsulation in different biomicrospheres using bovine serum albumin and chitosan [44] or lipid-based nanoparticles [45].…”

Section: Introductionmentioning

confidence: 99%

Improvement of mechanical and biological properties of Polycaprolactone loaded with Hydroxyapatite and Halloysite nanotubes

Torres

Fombuena

Vallés-Lluch

et al. 2017

Materials Science and Engineering: C

View full text Add to dashboard Cite

Hydroxyapatite (HA) and Halloysite nanotubes (HNTs) percentages have been optimized in Polycaprolactone (PCL) polymeric matrices to improve mechanical, thermal and biological properties of the composites, thus, to be applied in bone tissue engineering or as fixation plates. Addition of HA guarantees a proper compatibility with human bone due to its osteoconductive and osteoinductive properties, facilitating bone regeneration in tissue engineering applications. Addition of HNTs ensures the presence of tubular structures for subsequent drug loading in their lumen, of molecules such as curcumin, acting as controlled drug delivery systems. The addition of 20% of HA and different amounts of HNTs leads to a substantial improvement in mechanical properties with values of flexural strength up to 40% over raw PCL, with an increase in degradation temperature. DMA analyses showed stability in mechanical and thermal properties, having as a result a potential composite to be used as tissue engineering scaffold or resorbable fixation plate.

show abstract

“…The majority of the inorganic component of natural bone is calcium phosphates, which makes this group of materials very populate in bone tissue engineering [61][62][63] . Among all calcium phosphates, HA (Ca 10 (PO4) 6 (OH) 2 ) and TCP (Ca 3 (PO 4 ) 2 ) have been effective elements of many bone substitutes and scaffolds as they are able to effectively facilitate osteogenesis [64][65][66][67] . TCP is known as a bioceramic with higher degradability compared to other calcium phosphates [68][69][70][71] .…”

Section: Resultsmentioning

confidence: 99%

A tri-component knee plug for the 3rd generation of autologous chondrocyte implantation

Tayebi

Cui

2020

Sci Rep

Self Cite

View full text Add to dashboard Cite

Here, we report a newly designed knee plug to be used in the 3rd generation of Autologous Chondrocyte Implantation (ACI) in order to heal the damaged knee cartilage. It is composed of three components: The first component (Bone Portion) is a 3D printed hard scaffold with large pores (~ 850 µm), made by hydroxyapatite and β-tricalcium phosphate to accommodate the bony parts underneath the knee cartilage. It is a cylinder with a diameter of 20 mm and height of 7.5 mm, with a slight dome shape on top. The plug also comprises a Cartilage Portion (component 2) which is a 3D printed gelatin/elastin/sodium-hyaluronate soft thick porous membrane with large pores to accommodate chondrocytes. Cartilage Portion is secured on top of the Bone Portion using mechanical interlocking by designing specific knobs in the 3D printed construct of the Cartilage Portion. The third component of the plug (Film) is a stitchable permeable membrane consisting of polycaprolactone (PCL) on top of the Cartilage Portion to facilitate sliding of the knee joint and to hold the entire plug in place while allowing nutrients delivery to the Cartilage Portion. The PCL Film is prepared using a combination of film casting and sacrificial material leaching with a pore size of 10 µm. It is surface modified to have specific affinity with the Cartilage Portion. The detailed design criteria and production process of this plug is presented in this report. Full in vitro analyses have been performed, which indicate the compatibility of the different components of the plug relative to their expected functions.

show abstract

Efficacy of the biomaterials 3 wt%-nanostrontium-hydroxyapatite-enhanced calcium phosphate cement (nanoSr-CPC) and nanoSr-CPC-incorporated simvastatin-loaded poly(lactic- co -glycolic-acid) microspheres in osteogenesis improvement: An explorative multi-phase experimental in vitro/vivo study

Cited by 38 publications

References 45 publications

Development of 3D-printed PLGA/TiO2 nanocomposite scaffolds for bone tissue engineering applications

Development of 3D-printed PLGA/TiO2 nanocomposite scaffolds for bone tissue engineering applications

Improvement of mechanical and biological properties of Polycaprolactone loaded with Hydroxyapatite and Halloysite nanotubes

A tri-component knee plug for the 3rd generation of autologous chondrocyte implantation

Contact Info

Product

Resources

About