Efficacy of the aqueous extract of Siwa dates in protection against the whole body γ irradiation induced damages in mice

Fruits and their phytochemicals in mitigating the ill effects of ionizing radiation: review on the existing scientific evidence and way forward

“…169 Finally, the histopathological results indicated that the mice fed with dates and exposed to radiation had reduced levels of liver damage as observed by a quantitative decrease in inflammatory cell infiltration, hepatocyte degeneration and high expression levels of both TIMP 1 and MMP 9. 169…”

“…169 Flow cytometric studies with hepatocytes also showed that compared to the radiation-alone cohorts, the group feed with dates before radiation had an increased number of viable cells and reduced levels of both necrotic and apoptotic hepatocytes. 169 Mechanistic studies indicated that this effect was mediated at least in part by the down-regulation of Bax, p53, caspase-3, caspase-8 and an increase in anti-apoptotic protein Bcl2. 169 Finally, the histopathological results indicated that the mice fed with dates and exposed to radiation had reduced levels of liver damage as observed by a quantitative decrease in inflammatory cell infiltration, hepatocyte degeneration and high expression levels of both TIMP 1 and MMP 9.…”

“…169 The MN assay with the cytokinesis-blocked method indicated that date treatment reduced the radiation-induced DNA damage. 169 Additionally, studies with the liver and lymphocytes had also shown that mice treated with dates before radiation exposure had reduced levels of pro-inflammatory cytokines like TNF-α, IFN-γ and IL-β, decreased levels of MDA, concomitantly increased antioxidant GSH, SOD and CAT activities, and decreased levels of matrix metalloproteinases MMP 9 and TIMP 1. 169 Flow cytometric studies with hepatocytes also showed that compared to the radiation-alone cohorts, the group feed with dates before radiation had an increased number of viable cells and reduced levels of both necrotic and apoptotic hepatocytes.…”

“…169 Additionally, studies with the liver and lymphocytes had also shown that mice treated with dates before radiation exposure had reduced levels of pro-inflammatory cytokines like TNF-α, IFN-γ and IL-β, decreased levels of MDA, concomitantly increased antioxidant GSH, SOD and CAT activities, and decreased levels of matrix metalloproteinases MMP 9 and TIMP 1. 169 Flow cytometric studies with hepatocytes also showed that compared to the radiation-alone cohorts, the group feed with dates before radiation had an increased number of viable cells and reduced levels of both necrotic and apoptotic hepatocytes. 169 Mechanistic studies indicated that this effect was mediated at least in part by the down-regulation of Bax, p53, caspase-3, caspase-8 and an increase in anti-apoptotic protein Bcl2.…”

“…169 Mechanistic studies indicated that this effect was mediated at least in part by the down-regulation of Bax, p53, caspase-3, caspase-8 and an increase in anti-apoptotic protein Bcl2. 169 Finally, the histopathological results indicated that the mice fed with dates and exposed to radiation had reduced levels of liver damage as observed by a quantitative decrease in inflammatory cell infiltration, hepatocyte degeneration and high expression levels of both TIMP 1 and MMP 9. 169…”