“…Haemophilus proteins P2 and P6 have each been demonstrated to be specific targets of human bactericidal antibodies (42,43), and immunization of animals with the P6 protein has been demonstrated to modify the course of experimental disease (22). Immunization of animals with the P5-fimbrin adhesion protein, another leading vaccine candidate, or with peptides derived from the protein has also been demonstrated to modify the course of experimental infection in chinchillas and rats (4,5,37). Other proteins demonstrating protection against nontypeable Haemophilus disease following immunization in various experimental systems include recombinant HtrA (40), transferrin receptor (62), OMP26 (24,37), and lipoprotein D (1,2,49).…”