Efficacy of text-message reminders on paediatric malaria treatment adherence and their post-treatment return to health facilities in Kenya: a randomized controlled trial

Talisuna, Ambrose; Oburu, Amos; Githinji, Sophie; Malinga, Josephine; Amboko, Beatrice; Bejon, Philip; Jones, Caroline; Snow, Robert W.; Zurovac, Dejan

doi:10.1186/s12936-017-1702-6

Cited by 15 publications

(22 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…That study was based in a specific area and recommended further studies on health care promotion, intervention, and better communication regarding sustainable behavior changes [ 17 ]. Another study conducted in Kenya observing the efficacy of text-message reminders found that text-message reminders can increase a child’s compliance with respect to follow-up after anti-malarial treatment [ 18 ]. However, the effects of existing knowledge, attitude, and practices (KAP) of Kenyan populations with regard to malaria prevention strategies are rarely examined.…”

Section: Introductionmentioning

confidence: 99%

Prevalence and associated determinants of malaria parasites among Kenyan children

et al. 2017

View full text Add to dashboard Cite

BackgroundApproximately 80% of deaths attributed to malaria worldwide occurred mainly in Africa in 2015. Kenya is one of the major malaria endemic countries, making malaria the leading public health concern in this country. This study intended to document the prevalence of malaria and determine associated factors including socioeconomic status among children aged 6 months to 14 years in Kenya.MethodsThis study analyzed the secondary data extracted from the 2015 Kenya Malaria Indicator Survey (KMIS), a cross-sectional country representative survey. Associations of demographic, socioeconomic, community-based, and behavioral factors with the prevalence of malaria in children were analyzed using multivariable logistic regression analysis.ResultsData from 7040 children aged 6 months to 14 years were analyzed. The prevalence of malaria showed an upward trend in terms of age, with the highest prevalence among children aged 11–14 years. Prevalence was also higher among rural children (10.16%) compared to urban children (2.93%), as well as poor children (11.05%) compared to rich children (3.23%). The likelihood of having malaria was higher among children aged 10–14 years (AOR = 4.47, 95% CI = 3.33, 6.02; P < 0.001) compared with children aged under 5 years. The presence of anemia (AOR = 3.52, 95% CI = 2.78, 4.45; P < 0.001), rural residence (AOR = 1.71, 95% CI = 1.31, 2.22; P < 0.001), lack of a hanging mosquito net (AOR = 2.38, 95% CI = 1.78, 3.19; P < 0.001), primary education level of the household head (AOR = 1.15, 95% CI = 1.08, 2.25; P < 0.05), and other factors, such as the household having electricity and access to media such as television or radio, were also associated with the likelihood of infection.ConclusionThis study demonstrated the need to focus on awareness programs to prevent malaria and to use existing knowledge in practice to control the malaria burden in Kenya. Furthermore, this study suggests that improving the information available through the mass media and introducing behavior change communication and intervention program specifically for those of poor socioeconomic status will help to reduce malaria cases.

show abstract

Section: Introductionmentioning

confidence: 99%

Prevalence and associated determinants of malaria parasites among Kenyan children

et al. 2017

View full text Add to dashboard Cite

show abstract

“…A variety of approaches have been used to incorporate package inspection in the classification of adherence outcome [ 36 , 59 , 60 ]. Under trial conditions, blister packages have been retained and inspected with results successfully incorporated into the outcome measurement [ 61 ]. In other studies, package inspection has been included in the methods, but either excluded from the analysis [ 62 ], or not utilized altogether.…”

Section: Discussionmentioning

confidence: 99%

“…Instead, examining the quality of treatment, including whether the correct number of tablets were given at the correct frequency for the correct number of days, may provide a more accurate picture of treatment adherence [ 35 , 37 , 59 , 63 , 66 ]. Recently studies measuring anti-malarial adherence have presented per-dose adherence measurements [ 36 , 59 , 61 ], this approach is useful as it can illustrate at which point patients stop taking their medications. However, this approach like those mentioned earlier relies on self-report, with or without package validation.…”

Section: Discussionmentioning

confidence: 99%

Adherence to treatment with artemether–lumefantrine or amodiaquine–artesunate for uncomplicated malaria in children in Sierra Leone: a randomized trial

Banek

Webb

Smith

et al. 2018

Malar J

View full text Add to dashboard Cite

BackgroundPrompt, effective treatment of confirmed malaria cases with artemisinin-based combination therapy (ACT) is a cornerstone of malaria control. Maximizing adherence to ACT medicines is key to ensuring treatment effectiveness.MethodsThis open-label, randomized trial evaluated caregiver adherence to co-formulated artemether–lumefantrine (AL) and fixed-dose amodiaquine–artesunate (AQAS) in Sierra Leone. Children aged 6–59 months diagnosed with malaria were recruited from two public clinics, randomized to receive AL or AQAS, and visited at home the day after completing treatment. Analyses were stratified by site, due to differences in participant characteristics and outcomes.ResultsOf the 784 randomized children, 680 (85.6%) were included in the final per-protocol analysis (340 AL, 340 AQAS). Definite adherence (self-reported adherence plus empty package) was higher for AL than AQAS at both sites (Site 1: 79.4% AL vs 63.4% AQAS, odds ratio [OR] 2.16, compared to probable adherence plus probable or definite non-adherence, 95% confidence interval [CI] 1.34–3.49; p = 0.001; Site 2: 52.1% AL vs 37.5% AQAS, OR 1.53, 95% CI 1.00–2.33, p = 0.049). However, self-reported adherence (ignoring drug package inspection) was higher for both regimens at both sites and there was no strong evidence of variation by treatment (Site 1: 96.6% AL vs 95.9% AQAS, OR 1.19, 95% CI 0.39–3.63, p = 0.753; Site 2: 91.5% AL vs 96.4% AQAS, OR 0.40, 95% CI 0.15–1.07, p = 0.067). In Site 2, correct treatment (correct dose + timing + duration) was lower for AL than AQAS (75.8% vs 88.1%, OR 0.42, 95% CI 0.23–0.76, p = 0.004). In both sites, more caregivers in the AQAS arm reported adverse events (Site 1: 3.4% AL vs 15.7% AQAS, p < 0.001; Site 2: 15.2% AL vs 24.4% AQAS, p = 0.039).ConclusionsSelf-reported adherence was high for both AL and AQAS, but varied by site. These results suggest that each regimen has potential disadvantages that might affect adherence; AL was less likely to be taken correctly at one site, but was better tolerated than AQAS at both sites. Measuring adherence to anti-malarials remains challenging, but important. Future research should focus on comparative studies of new drug regimens, and improving the methodology of measuring adherence.Trial registration: Clinicaltrials.gov, NCT01967472. Retrospectively registered 18 October 2013, https://clinicaltrials.gov/ct2/show/NCT01967472Electronic supplementary materialThe online version of this article (10.1186/s12936-018-2370-x) contains supplementary material, which is available to authorized users.

show abstract

“…Results from trials using SMS to increase adherence to malaria treatment and to treatment for other diseases such as HIV and TB have shown mixed results [47–50]. Content and type of messaging need to be well developed, tested and refined and locally adapted for their implementation to be successful [51, 52].…”

Section: Topic 4: Improving the Adherence To A Full Course Of Primaqumentioning

confidence: 99%

Challenges for achieving safe and effective radical cure of Plasmodium vivax: a round table discussion of the APMEN Vivax Working Group

Thriemer¹,

Ley²,

Bobogare³

et al. 2017

Malar J

View full text Add to dashboard Cite

The delivery of safe and effective radical cure for Plasmodium vivax is one of the greatest challenges for achieving malaria elimination from the Asia–Pacific by 2030. During the annual meeting of the Asia Pacific Malaria Elimination Network Vivax Working Group in October 2016, a round table discussion was held to discuss the programmatic issues hindering the widespread use of primaquine (PQ) radical cure. Participants included 73 representatives from 16 partner countries and 33 institutional partners and other research institutes. In this meeting report, the key discussion points are presented and grouped into five themes: (i) current barriers for glucose-6-phosphate deficiency (G6PD) testing prior to PQ radical cure, (ii) necessary properties of G6PD tests for wide scale deployment, (iii) the promotion of G6PD testing, (iv) improving adherence to PQ regimens and (v) the challenges for future tafenoquine (TQ) roll out. Robust point of care (PoC) G6PD tests are needed, which are suitable and cost-effective for clinical settings with limited infrastructure. An affordable and competitive test price is needed, accompanied by sustainable funding for the product with appropriate training of healthcare staff, and robust quality control and assurance processes. In the absence of quantitative PoC G6PD tests, G6PD status can be gauged with qualitative diagnostics, however none of the available tests is currently sensitive enough to guide TQ treatment. TQ introduction will require overcoming additional challenges including the management of severely and intermediately G6PD deficient individuals. Robust strategies are needed to ensure that effective treatment practices can be deployed widely, and these should ensure that the caveats are outweighed by the benefits of radical cure for both the patients and the community. Widespread access to quality controlled G6PD testing will be critical.

show abstract

Efficacy of text-message reminders on paediatric malaria treatment adherence and their post-treatment return to health facilities in Kenya: a randomized controlled trial

Cited by 15 publications

References 42 publications

Prevalence and associated determinants of malaria parasites among Kenyan children

Prevalence and associated determinants of malaria parasites among Kenyan children

Adherence to treatment with artemether–lumefantrine or amodiaquine–artesunate for uncomplicated malaria in children in Sierra Leone: a randomized trial

Challenges for achieving safe and effective radical cure of Plasmodium vivax: a round table discussion of the APMEN Vivax Working Group

Contact Info

Product

Resources

About