Efficacy of Tart Cherry Juice to Reduce Inflammation Biomarkers among Women with Inflammatory Osteoarthritis (OA)

Kuehl, Kerry S.; Elliot, Diane L.

doi:10.5296/jfs.v1i1.1927

Cited by 8 publications

(15 citation statements)

References 29 publications

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“…A recent randomized, placebo-controlled trial in 20 middle aged and elderly females with osteoarthritis gave limited evidence of a reduction in inflammation with tart cherry juice consumption [41]. These authors found the adults with moderate OA pain in the tart cherry juice group had a significant decrease in CRP from baseline, but only after an apparent outlying high value participant was removed from calculation.…”

Section: Tart Cherry and Arthritismentioning

confidence: 92%

Section: Discussionmentioning

confidence: 99%

“…Several authors did not appear to exclude the use of pain medication or anti-inflammatories, while some at least required a stable medication dosage [13,19,22,41,44]. Some of these studies were conducted on patients who were receiving standard routine care for a chronic disease condition, which may have included NSAIDs, COX-2 inhibitors, or other agents that affect inflammation [17,19,40,41]. Dosages in human studies were generally equal to about 100 cherries daily, but anthocyanin and phenolic content varied (80-274 mg and 1100-1200 mg daily, respectively) [13,14,17,19,21,41,42,46,48].…”

Section: Discussionmentioning

confidence: 99%

“…Some of these studies were conducted on patients who were receiving standard routine care for a chronic disease condition, which may have included NSAIDs, COX-2 inhibitors, or other agents that affect inflammation [17,19,40,41]. Dosages in human studies were generally equal to about 100 cherries daily, but anthocyanin and phenolic content varied (80-274 mg and 1100-1200 mg daily, respectively) [13,14,17,19,21,41,42,46,48]. In the case of the Tall study (2004), rats were given doses of up to 400 mg anthocyanins [45].…”

Section: Discussionmentioning

confidence: 99%

“…No significant changes were found in IL-6, IL-10, or TNF-␣. Surprisingly, though the study purported to measure pain via Western Ontario McMaster Osteoarthritis Index (WOMAC) and a visual analog scale (VAS), the results were not reported [41].…”

Section: Tart Cherry and Arthritismentioning

confidence: 99%

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Tart cherry in amelioration of pain in the elderly

Tiernan

Imrhan

Prasad

et al. 2016

NUA

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Abstract. BACKGROUND:Tart cherry, rich in bioactive polyphenols, has received attention in the past decade for reported health benefits due to its high polyphenolic content. OBJECTIVE: To determine whether there is a potential role for tart cherry or its isolated components in amelioration of pain relief in chronic diseases that may affect the elderly. METHODS:In vitro and in vivo human and animal studies that utilized tart cherry or extracts of tart cherry compounds to determine an effect on oxidative stress, inflammation, muscle damage, and pain were reviewed and summarized (Table 1). RESULTS: Tart cherry and its isolated compounds have demonstrated antioxidant and anti-inflammatory effects both in vitro and in vivo which may improve self-reported pain. In humans, these include modest improvements in gout flare incidents, and self-reported pain in fibromyalgia, osteoarthritis (OA), and conditions of induced oxidative stress and muscle damage. Beneficial biochemical changes were also reported for inflammatory and oxidative biomarkers such as serum urate, C-reactive protein (CRP), and interleukin-6 (IL-6). However, most studies reported to date have insufficient sample size, treatment duration, and statistical power to draw any firm conclusions. CONCLUSIONS: Consumption of tart cherries and their bioactive constituents may be a potential novel therapy for reducing the pain associated with chronic diseases particularly common to an aged population. Larger, more rigorous trials are needed to reach any firm conclusions.

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Section: Tart Cherry and Arthritismentioning

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Tart Cherry and Arthritismentioning

confidence: 99%

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Tart cherry in amelioration of pain in the elderly

Tiernan

Imrhan

Prasad

et al. 2016

NUA

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Fruits

Mohammed¹,

Qoronfleh²

2020

Advances in Neurobiology

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The efficacy of a tart cherry drink for the treatment of patellofemoral pain in recreationally active individuals: a placebo randomized control trial

et al. 2022

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Purpose This study aimed to explore the efficacy of U.S. Montmorency tart cherry in treating recreationally active individuals with patellofemoral pain. Methods Twenty-four recreationally active participants with patellofemoral pain were randomly separated into either placebo (males N = 8, females N = 4, age = 43.30 ± 7.86 yrs, mass = 72.10 ± 17.89 kg, stature = 171.16 ± 10.17, BMI = 24.31 ± 3.75 kg/m2, symptom duration = 30.18 ± 10.90) or Montmorency tart cherry (males N = 9, females N = 3, age = 41.75 ± 7.52 yrs, mass = 76.96 ± 16.64 kg, stature = 173.05 ± 7.63, BMI = 25.53 ± 4.03 kg/m2, symptom duration = 29.73 ± 11.88) groups. Both groups ingested 60 mL of either Montmorency tart cherry concentrate or taste matched placebo daily for 6 weeks. Measures of self-reported pain (KOOS-PF), psychological wellbeing (COOP WONCA), and sleep quality (PSQI) alongside blood biomarkers (C-reactive protein, uric acid, TNF alpha, creatinine, and total antioxidant capacity) and knee biomechanics were quantified at baseline and 6 weeks. Differences between groups were examined using linear mixed-effects models. Results There was 1 withdrawal in the cherry and 0 in the placebo group and no adverse events were noted in either condition. The placebo condition exhibited significant improvements (baseline = 67.90 ± 16.18 & 6 weeks = 78.04 ± 14.83) in KOOS-PF scores compared to the tart cherry group (baseline = 67.28 ± 12.55& 6 weeks = 67.55 ± 20.61). No other statistically significant observations were observed. Conclusion Tart cherry supplementation as specifically ingested in the current investigation does not appear to be effective in mediating improvements in patellofemoral pain symptoms in recreationally active individuals.

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Efficacy of Tart Cherry Juice to Reduce Inflammation Biomarkers among Women with Inflammatory Osteoarthritis (OA)

Cited by 8 publications

References 29 publications

Tart cherry in amelioration of pain in the elderly

Tart cherry in amelioration of pain in the elderly

Fruits

The efficacy of a tart cherry drink for the treatment of patellofemoral pain in recreationally active individuals: a placebo randomized control trial

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