Efficacy of Tacrolimus Versus Clobetasol in the Treatment of Vitiligo

Mumtaz, Hassan; Anis, Salwa; Akhtar, Asif; Rubab, Masooma; Zafar, Ayesha; Niazi, Nayab; Bahadur, Hina; Talpur, Abdul Subhan; Shafiq, Muhammad; Fatima, Tehreem

doi:10.7759/cureus.11985

Cited by 8 publications

(5 citation statements)

References 10 publications

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“…This findings consistent with other studies accords the world. 1,5,6 This study findings does not accord with the findings of Grimes et al where they found 41.3%. 14 Excellent repigmentation was noted, 76-100%, in 2 (2.9%) patients.…”

Section: Characteristiccontrasting

confidence: 91%

“…Mean age of this study group was 28.52±10.98 years which concurs with other similar studies. 1,16 This study shows the mean involvement of the body surface area before treatment was 6.84%, which is reduce to 4.25% after treatment. It revealed that there is a strong association between tacrolimus use and repigmentation (P< 0.001).…”

Section: Characteristicmentioning

confidence: 70%

“…Vitiligo is an acquired pigmentary disorder of the skin, characterized by the loss of function of melanocytes in the epidermis and well-circumscribed, asymptomatic pearly white macules varying in size and shape which tend to extend and increase centrifugally with time in an unpredictable way. 1 Segmental vitiligo has depigmented macules arranged in a dermatomal or quasi-dermatomal distribution, which does not cross the midline and is usually unresponsive to medical treatment. 2 Tacrolimus and topical corticosteroids are effective in treating vitiligo, 3 but there are not many studies conducted on segmental vitiligo.…”

Section: Introductionmentioning

confidence: 99%

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Effectiveness of topical tacrolimus treatment in vitiligo patients

Basak¹,

Debnath²,

Das³

2023

CeMeC Journal

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Background: Vitiligo is an acquired, pigmentary skin disorder that is disfiguring and difficult to treat. Phototherapy and the application of topical corticosteroids are most commonly prescribed. However, these therapies are often not effective and the use of corticosteroids on the face may lead to cutaneous atrophy, telangiectasia, and ocular complications. Objective: To evaluate the effectiveness of topical tacrolimus treatment in vitiligo patients. Materials and methods: This prospective, randomized control trial study was conducted among the patients who sought health care in the Dermatology and Venereology out patient department of KYAMC, Enayetpur, Sirajgonj from August 2021 to July 2022. The study was conducted with a view to evaluate the efficacy of topical tacrolimus in vitiligo and to see the adverse effects of topical tacrolimus in the treatment of vitiligo. Results: This study shows 70 patients were enrolled them 32 were male and 38 were female. The mean age was 28.52±10.98 years. Monthly evaluations were performed. Maximum 61 patients (87.1%) achieved varying levels of repigmentation. 28 patients (40.0%) had reported up to 50% repigmentation. Sign and symptoms of erythema (8.6%) and burning (7.1%) were minimal. Conclusion: This study revealed that tacrolimus ointment may be an effective and safe option for the treatment of vitiligo. The ease of topical self-administration with minimal side effects makes this novel immunomodulatory agent a promising addition to the therapeutic armamentarium for vitiligo. Central Medical College Journal Vol 6 No 1 January 2022 Page: 44-48

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Section: Characteristiccontrasting

confidence: 91%

Section: Characteristicmentioning

confidence: 70%

Section: Introductionmentioning

confidence: 99%

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Effectiveness of topical tacrolimus treatment in vitiligo patients

Basak¹,

Debnath²,

Das³

2023

CeMeC Journal

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“…Treatment with topical betamethasone dipropionate 0.05% cream twice daily showed moderate improvement (25–50% repigmentation) in 46.7% of patients with vitiligo at 3 months [57]. In a randomized controlled trial, a comparison of topical clobetasol propionate 0.05% and tacrolimus 0.1% in patients with vitiligo showed comparable efficacy (58.0% vs. 51.9%) [58]. In addition, the combination of a mid-potent topical corticosteroid and NBUVB or EL significantly increased the repigmentation response compared to phototherapy alone [59‒61].…”

Section: Topical Agentsmentioning

confidence: 99%

Bridging Molecular Mechanism and Clinical Practice in Vitiligo Treatment: An Updated Review

Ju,

Bae

2024

Dermatology

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Background: In recent years, a great advance has been made in the area of pathogenesis of vitiligo and the understanding of vitiligo treatment is also expanding. Summary: Treatment of vitiligo seeks to achieve three goals: cessation of disease progression, regeneration of pigmentation, and prevention of recurrence. To achieve these goals, a number of non-surgical interventions are available that suppress the autoimmune response and regenerate the remaining melanocytes from the reservoir, and optimal treatment outcome can be achieved when each modality is used properly. Key Messages: Our review describes various treatment modalities for vitiligo based on their molecular mechanism of action. Bridging the gap between molecular mechanisms and therapeutic options would be a valuable reference for physicians in clinical practice.

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“…Several factors, such as genetic, autoimmune, psychological, and environmental factors, are believed to be involved in the occurrence and development of this disorder. 1 , 3 , 4 Despite the fact that the onset of the condition can occur at any point in life, vitiligo occurs before 20 years of age in 50% of patients 5 , 6 .Vitiligo is generally asymptomatic and neither reduces individual physical activity nor shortens life expectancy. However, this chronic disease may significantly impair quality of life for individuals.…”

Section: Introductionmentioning

confidence: 99%

Post-Traumatic Stress in Vitiligo Patients: A Neglected but Real-Existing Psychological Impairment

JW¹,

Tan²,

Chen³

et al. 2022

CCID

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Background Vitiligo is the most common depigmentation disorder. This disease causes disfiguration and induces psychological burdens, leading to significantly impaired quality of life. Limited research about disease-related post-traumatic stress (PTS) has been conducted in vitiligo patients. Objective To evaluate the prevalence, severity, and risk factors of post-traumatic stress in vitiligo patients. Methods This case-control study was performed from January 2021 to April 2021. A survey questionnaire including baseline information, post-traumatic stress symptoms evaluation, life quality evaluation was conducted. According to the severity of post-traumatic stress symptoms, patients were grouped and compared. The logistic regression model was conducted to analyze the risk factors for post-traumatic stress disorder (PTSD). Results A total of 337 patients were included. A 30.3% of vitiligo patients (102/337) in present cohort had PTS and 12.5% patients (42/337) were confirmed for developing into PTSD. The multivariate logistic regression revealed educational level

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Efficacy of Tacrolimus Versus Clobetasol in the Treatment of Vitiligo

Cited by 8 publications

References 10 publications

Effectiveness of topical tacrolimus treatment in vitiligo patients

Effectiveness of topical tacrolimus treatment in vitiligo patients

Bridging Molecular Mechanism and Clinical Practice in Vitiligo Treatment: An Updated Review

Post-Traumatic Stress in Vitiligo Patients: A Neglected but Real-Existing Psychological Impairment

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