Efficacy of systemic and intratympanic corticosteroid combination therapy versus intratympanic or systemic therapy in patients with idiopathic sudden sensorineural hearing loss: a randomized controlled trial

Ashtiani, Mohammadtaghi Khorsandi; Firouzi, Farzad; Bastaninejad, Shahin; Dabiri, Sasan; Nasirmohtaram, Sevil; Saeedi, Niloufar; Ghazavi, Hossein; Sahebi, Leyla

doi:10.1007/s00405-017-4808-0

Cited by 24 publications

(20 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The analysis revealed that combined therapy seems to confer a certain degree of benefit as primary treatment of SSNHL compared with only systemic treatment. In a randomised, triple-blind, controlled trial in 2017 23 on 112 patients, 32 received IT corticosteroids, 45 received systemic corticosteroids and 35 received a combination of the two. No differences were found in hearing recovery between the three therapeutic approaches.…”

Section: Discussionmentioning

confidence: 99%

Prediction of hearing recovery in sudden deafness treated with intratympanic steroids

Attanasio

Russo

Porto³

et al. 2018

Acta Otorhinolaryngol Ital

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Prediction of hearing recovery in sudden deafness treated with intratympanic steroids

Attanasio

Russo

Porto³

et al. 2018

Acta Otorhinolaryngol Ital

View full text Add to dashboard Cite

“…The titles and abstracts of the remaining 435 articles were checked, and 202 full-text articles were further appraised. We finally identified 20 RCTs, 2,10,[13][14][15][22][23][24][25][26][27][28][29][30][31][32][33][34][35][36] including 1716 patients eligible for the analysis on the prognosis of SSHL ( Figure 1). All included RCTs were evaluated to be at low risk of bias via Cochrane risk of bias tool (see online appendix).…”

Section: Included Studies and Baseline Characteristics Of Participantsmentioning

confidence: 99%

Effectiveness of Steroid Treatment for Sudden Sensorineural Hearing Loss: A Meta-analysis of Randomized Controlled Trials

Ding

2020

Ann Pharmacother

View full text Add to dashboard Cite

Background: The best way to administer steroids for sudden sensorineural hearing loss (SSHL) is still unclear. The present study was aimed at estimating the efficacy of steroids by intratympanic, systemic, and combined therapy (CT) routes. Methods: A systematic literature search was performed from 1950 to October 2019 for randomized controlled trials comparing the use of intratympanic, systemic, and combined steroid therapy for SSHL. The outcomes of recovery rate and pure tone average (PTA) improvement were assessed by random-effects and fixed-effects meta-analysis. Results: A total of 20 articles identified from 7 countries were eligible for analysis. Although no significant difference in recovery rate was observed between intratympanic steroid therapy (IST) and systemic steroid therapy (SST), IST did demonstrate better hearing improvement, as evidenced by a higher PTA than SST. Compared with SST, CT comprising IST and SST had significant recovery rate improvement. Patients treated with CT had a significantly higher PTA than those treated with SST. Through subgroup analysis based on the equivalent dose of prednisone, it was shown that CT led to a significantly higher PTA than SST only in the high-dose CT versus high-dose SST groups and moderate-dose CT versus high-dose SST groups. Conclusion: Moderate and high dose of CT could accelerate hearing improvement in SSHL.

show abstract

“…Kedvezőtlen prognosztikai faktornak találtuk a magas frekvenciákon kialakult halláscsökkenést [22]. Betegeinknél a legkisebb javulást 8000 Hz-en, míg a legjelentősebbet 125 Hz-en tudtuk regisztrálni.…”

Section: áBraunclassified

A hirtelen halláscsökkenés javulásában szerepet játszó prognosztikai faktorok vizsgálata

et al. 2019

View full text Add to dashboard Cite

Sudden sensorineural hearing loss is defined as a greater than 30 dB deterioration in at least 3 consecutive frequencies occurring within 72 hours. The disease is mostly idiopathic and needs an urgent treatment. Between 01. 01. 2015 and 31. 12. 2016, 149 patients with sudden hearing loss were admitted to the Department of Otorhinolaryngology, University of Pécs. The epidemiological data, the prognostic factors and the outcome of the treatment were retrospectively analyzed. Isolated high frequency (p = 0.012) and less severe hearing loss (p<0.001), older age (p = 0.005), comorbodities like cardiovascular disease (p = 0.009) and diabetes (p = 0.029) were found as negative prognostic factors. Time of introduction of the treatment, gender, and side of the affected ear did not influence the outcome. Our finding was mainly congruent to the literature. Orv Hetil. 2019; 160(18): 687–693.

show abstract

Efficacy of systemic and intratympanic corticosteroid combination therapy versus intratympanic or systemic therapy in patients with idiopathic sudden sensorineural hearing loss: a randomized controlled trial

Abstract: 1b.

Cited by 24 publications

References 26 publications

Prediction of hearing recovery in sudden deafness treated with intratympanic steroids

Prediction of hearing recovery in sudden deafness treated with intratympanic steroids

Effectiveness of Steroid Treatment for Sudden Sensorineural Hearing Loss: A Meta-analysis of Randomized Controlled Trials

A hirtelen halláscsökkenés javulásában szerepet játszó prognosztikai faktorok vizsgálata

Contact Info

Product

Resources

About