Efficacy of Sumatriptan Nasal Spray in Recurrent Migrainous Headache: An Open Prospective Study

Carpay, J. A.; Linssen, W.H.J.P.; Koehler, P.J.; Arends, Lidia R.; Tiedink, H.G.M.

doi:10.1046/j.1526-4610.2003.03075.x

Cited by 4 publications

(2 citation statements)

References 7 publications

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“…20 The results from this small, openlabel study suggested that intranasal and oral sumatriptan may be effective for probable migraine. The current study is therefore important as it was the first large, well-controlled clinical trial to study the probable migraine population.…”

Section: Discussionmentioning

confidence: 87%

“…Only one other published report has evaluated the efficacy of sumatriptan in the treatment of probable migraine attacks in patients without a concomitant migraine diagnosis. 20 The results from this small, openlabel study suggested that intranasal and oral sumatriptan may be effective for probable migraine. The current study is therefore important as it was the first large, well-controlled clinical trial to study the probable migraine population.…”

Section: Discussionmentioning

confidence: 87%

See 1 more Smart Citation

Oral Sumatriptan for the Acute Treatment of Probable Migraine: First Randomized, Controlled Study

Tepper

Cady

Dodick³

et al. 2006

Headache

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Section: Discussionmentioning

confidence: 87%

Section: Discussionmentioning

confidence: 87%

Oral Sumatriptan for the Acute Treatment of Probable Migraine: First Randomized, Controlled Study

Tepper

Cady

Dodick³

et al. 2006

Headache

View full text Add to dashboard Cite

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Sumatriptan succinate: pharmacokinetics of different formulations in clinical practice

Lionetto

Negro

Casolla

et al. 2012

Expert Opinion on Pharmacotherapy

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Subcutaneous sumatriptan has been considered as the most efficacious treatment in the acute phase of migraine both on pain alone as well as on associated autonomic symptoms. Pharmacologically, pharmacokinetic parameters, in particular bioavailability, T(max) and C(max) are responsible for the wide efficacy of the compound and the limited adverse effect (AE) profile. The new drug formulations that are the most similar to the pharmacokinetics parameters of the subcutaneous one are promising because they both improve pharmacokinetic bioavailability bypassing the first-pass metabolism and increase patient compliance.

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Sumatriptan: a decade of use and experience in the treatment of migraine

Sheftell

Bigal

Tepper

et al. 2004

Expert Review of Neurotherapeutics

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The migraine-specific triptans have revolutionized the treatment of migraine and are usually the drugs of choice to treat a migraine attack in progress. Sumatriptan (Imitrex) has been available for the longest time within the class, is most flexible in form and has been given successfully to the most number of patients. It is useful for the full range of attacks experienced by a migraine suffer. The aim of this review is to provide an overview of the first 10 years of the use of sumatriptan.

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Efficacy of Sumatriptan Nasal Spray in Recurrent Migrainous Headache: An Open Prospective Study

Abstract: This is the first prospective study to show that intranasal or oral sumatriptan may be effective in patients experiencing moderate to severe headache attacks which consistently do not fulfill the IHS criteria for migraine or episodic tension-type headache.

Cited by 4 publications

References 7 publications

Oral Sumatriptan for the Acute Treatment of Probable Migraine: First Randomized, Controlled Study

Oral Sumatriptan for the Acute Treatment of Probable Migraine: First Randomized, Controlled Study

Sumatriptan succinate: pharmacokinetics of different formulations in clinical practice

Sumatriptan: a decade of use and experience in the treatment of migraine

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