Efficacy of Sucralfate in Refractory Reflux Esophagitis:Results of a Pilot Study

Pujol, Eugènia; Bordas, Josep M.; Grande, Luís

doi:10.3109/00365528909091038

Cited by 3 publications

(1 citation statement)

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“…Long term outcome Whereas two thirds of the patients had initially required H2 blockers, 52% and 55% of those available for follow up at three and six years, respectively, fared well with a conservative approach (Table III). Anti-reflux surgery resulted in long lasting remission ofreflux symptoms in 22 of 23 patients who were operated on and who have been followed up for 72 (15), range 54-1 16 months. Table IV shows the treatment needs during long term follow up in relation to the outcome of initial, graded treatment.…”

Section: Outcomes During Follow Upmentioning

confidence: 99%

Predictive factors of the long term outcome in gastro-oesophageal reflux disease: six year follow up of 107 patients.

Kuster

Ros

Toledo-Pimentel

et al. 1994

Gut

128

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There is little information concerning the long term outcome of patients with gastrooesophageal reflux disease (GORD). Thus 109 patients with reflux symptoms (33 with erosive oesophagitis) with a diagnosis of GORD after clinical evaluation and oesophageal testing were studied. AU patients were treated with a stepwise approach: (a) lifestyle changes were suggested aimed at reducing reflux and antacids and the prokinetic agent domperidone were prescribed; (b) H2 blockers were added after two months when symptoms persisted; (c) anti-reflux surgery was indicated when there was no response to (b). Treatment was adjusted to maintain clinical remission during follow up. Long term treatment need was defined as minor when conservative measures sufficed for proper control, and as major if daily H2 blockers or surgery were required. The results showed that one third of the patients each had initial therapeutic need (a), (b), and (c). Of 103 patients available for follow up at three years and 89 at six years, respective therapeutic needs were minor in 52% and 55% and major in 48% and 45%. Eighty per cent of patients in (a), 67% in (b), and 17% in (c) required only conservative measures at six years. A decreasing lower oesophageal sphincter pressure (p<0-001), radiological reflux (p=0028), and erosive oesophagitis (p=0-031), but not initial clinical scores, were independent predictors of major therapeutic need as shown by multivariate analysis. The long term outcome of GORD is better than previously perceived.

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Section: Outcomes During Follow Upmentioning

confidence: 99%