Efficacy of submucosal tramadol and lidocaine on success rate of inferior alveolar nerve block in mandibular molars with symptomatic irreversible pulpitis

Aksoy, Fatih; Eğe, Bilal

doi:10.1007/s10266-020-00485-0

Cited by 6 publications

(17 citation statements)

References 34 publications

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“… Post-injection Self-reported, questioned about systemic and local side effects Group A: 100 mg Tramadol Nausea (n = 1) No side effects reported in dexamethasone or saline groups.No statistically significant difference (p = 0.364). Total AE Tramadol: nausea (n = 1, 3%) Aksoy and Ege 2020b ; RCT Evaluation of the IANB success rate in mandibular molars with SIP comparing buccal submucosal administration of 100 mg tramadol (n = 35) vs 40 mg lidocaine (n = 35) vs saline (n = 35) administered 5 min after the IANB was performed with 1.8 mL of 2% lidocaine/1:80,000 adrenaline. Not stated Not stated Group A: 100 mg Tramadol Nausea (n = 3) Group B: 40 mg Lidocaine Nausea (n = 1) Group C: Saline Nausea (n = 0) No statistically significant difference (p = 0.218).…”

Section: Resultsmentioning

confidence: 99%

“…One study was related to upper molar exodontia ( Al-Haideri, 2013 ). Four studies investigated local tramadol use in endodontics relating to inferior alveolar nerve success in mandibular molars with symptomatic irreversible pulpitis ( Aksoy and Ege, 2020a , Aksoy and Ege, 2020b , De Pedro-Muñoz and Mena-Álvarez, 2017 , Rodríguez-Wong et al, 2016 ). Three studies reviewed local tramadol use, including duration and efficacy in a non-operative context ( Isiordia-Espinoza et al, 2012 , Jendi and Talathi, 2019 , Pozos et al, 2006 ).…”

Section: Resultsmentioning

confidence: 99%

“…One study compared tramadol against lidocaine/adrenaline with a placebo/saline control group as a local anaesthetic adjunct when anaesthesia was obtained via lidocaine/adrenaline ( Aksoy and Ege, 2020b ). Another study compared tramadol against dexamethasone with a placebo/saline control group as a local anaesthetic adjunct when anaesthesia was obtained via articaine/adrenaline ( Aksoy and Ege, 2020a ).…”

Section: Resultsmentioning

confidence: 99%

“…Most studies utilised either fixed tramadol doses of 50 mg ( Al-Haideri, 2013 , De Pedro-Muñoz and Mena-Álvarez, 2017 , Ege et al, 2020 , Isiordia-Espinoza et al, 2012 , Isiordia-Espinoza et al, 2011 , Jendi and Talathi, 2019 , Pozos et al, 2006 , Rodríguez-Wong et al, 2016 ) or 100 mg ( Ceccheti et al, 2014 , Khan et al, 2016 ), a fixed maximum doses of 50 mg ( Jendi et al, 2019 ) or utilised a 1 mg/kg dose ( Aksoy and Ege, 2020a , Aksoy and Ege, 2020b , Gönül et al, 2015 , Iqbal and Shetty, 2019 ).…”

Section: Resultsmentioning

confidence: 99%

“…Monitoring timeframes for reporting adverse effects varied including following injection ( Aksoy and Ege, 2020a ), post-operatively or after the procedure ( Ege et al, 2020 , Gönül et al, 2015 ), on the evening of the procedure ( Isiordia-Espinoza et al, 2011 ) or 24 h post-operatively ( Al-Haideri, 2013 , Jendi et al, 2019 , Jendi and Talathi, 2019 ). Most studies did not specify this timeframe ( Aksoy and Ege, 2020b , Ceccheti et al, 2014 , De Pedro-Muñoz and Mena-Álvarez, 2017 , Iqbal and Shetty, 2019 , Isiordia-Espinoza et al, 2012 , Khan et al, 2016 , Pozos et al, 2006 , Rodríguez-Wong et al, 2016 ).…”

Section: Resultsmentioning

confidence: 99%

See 4 more Smart Citations

Tramadol as a local anaesthetic agent in dentistry: A systematic review of local and systemic adverse effects

Mane

Choi

Sharpe-Davidson

2021

The Saudi Dental Journal

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Tramadol is an effective alternative local anaesthetic (LA) agent available in dentistry. This review aims to help guide practice by providing clinicians with relevant data regarding adverse effects (AE) associated with locally administered tramadol in the oral environment. A systematic search of three electronic databases was performed to identify relevant studies reporting AE associated with locally administered tramadol in the oral setting. Selected studies were reviewed and included based on inclusion and exclusion criteria. Data collected included: publication year, study design, participant numbers, adverse effects and follow-up duration. Fifteen articles were included comprising of 547 tramadol participants across eight exodontia and seven non-exodontia studies. Thirty-eight associated AE were reported. Nausea was the most commonly reported (4.6%), followed by dizziness (1.3%), vomiting (0.7%) and local erythema (0.4%). No other AE were reported. The prevalence of total AE was similar in ≥ 50 mg tramadol doses (7.2–7.3%); however the total affected number is not dose dependent. The prevalence of AE and affected participants was less when tramadol was used as a sole LA rather than as an adjunct (5.6% vs. 7.9% and 3.4–5.6% vs. 6.3%, respectively). Thus, tramadol is a safe LA agent with a low prevalence of AE when administered in the dental setting.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 3 more Smart Citations

Tramadol as a local anaesthetic agent in dentistry: A systematic review of local and systemic adverse effects

Mane

Choi

Sharpe-Davidson

2021

The Saudi Dental Journal

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Efficacy and safety of parenteral and local application of tramadol in mandibular third molar extraction: a qualitative systematic review of current evidence

Gounari,

Tsaousi,

Zouloumis

et al. 2023

Oral Maxillofac Surg

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The effect of pre‐operative submucosal administration of dexamethasone, tramadol, articaine on the success rate of inferior alveolar nerve block on mandibular molars with symptomatic irreversible pulpitis: A randomized, double‐blind placebo‐controlled clinical trial

2021

Self Cite

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Aim: To establish the effects of submucosal tramadol, dexamethasone and articaine on the success of inferior alveolar nerve blocks (IANB) during root canal treatment of mandibular molars with symptomatic irreversible pulpitis (SIP). Methodology:In this randomized double-blind, controlled clinical trial, 120 patients with the diagnosis of SIP in their mandibular first or second molars were included and randomly divided into four groups (n = 30). The control group received normal saline and three experimental groups received a single dose of dexamethasone (8 mg/2 mL), or tramadol (100 mg/2 mL) or articaine (4% / 2 mL). The pre-operative pain levels of the patients were measured with the Heft-Parker visual analogue scale (HP VAS). All patients received standard IANB of 4% articaine with 1:200000 epinephrine. Following the observation of lip numbness, submucosal injections were administered into the mucobuccal fold adjacent to the mandibular molars. After 15 min, standard root canal treatment was initiated, and the pain intensity levels recorded from the access cavity preparation to pulp extirpation were measured with HP VAS. The duration of the anaesthesia was also evaluated. The experimental groups were compared using one-way ANOVA or Kruskal-Wallis H-test. The groups that were significantly different were compared pairwise using the Tukey Multiple Comparison test. The Chi-square test was used to compare the categorical variables. Results:The submucosal administration of articaine significantly increased the success rate to 63% in comparison with the control group that received submucosal saline (p < .05). The success rate of pulpal anaesthesia was 37% in the control group, 57% in the tramadol group and 47% in the dexamethasone group, with no significant difference in the success rate among these groups. In the dexamethasone group, the duration of the anaesthetic effect of IANB was significantly longer than those in the other groups (p < .001). Conclusions:In patients with SIP, pre-operative submucosal administration of articaine increased the success rate of IANB, while administration of dexamethasone | 1983 AKSOY ET AL.

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Efficacy of submucosal tramadol and lidocaine on success rate of inferior alveolar nerve block in mandibular molars with symptomatic irreversible pulpitis

Cited by 6 publications

References 34 publications

Tramadol as a local anaesthetic agent in dentistry: A systematic review of local and systemic adverse effects

Tramadol as a local anaesthetic agent in dentistry: A systematic review of local and systemic adverse effects

Efficacy and safety of parenteral and local application of tramadol in mandibular third molar extraction: a qualitative systematic review of current evidence

The effect of pre‐operative submucosal administration of dexamethasone, tramadol, articaine on the success rate of inferior alveolar nerve block on mandibular molars with symptomatic irreversible pulpitis: A randomized, double‐blind placebo‐controlled clinical trial

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