Efficacy of Submucosal Sodium Tetradecyl Sulfate in the Soft Palate as a Treatment of the Mild Obstructive Sleep Apnea Syndrome: A Pilot Study

Labra, Alberto; Haro-Valencia, Reyes; Huerta-Delgado, Angel-Daniel; Jiménez‐Correa, Ulises; Sánchez-Narváez, Francisco

doi:10.1155/2012/597684

Cited by 7 publications

(3 citation statements)

References 10 publications

(13 reference statements)

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“…Recently Labra et al have done a pilot study using Polidocanol as submucosal injection in the soft palate in patients with mild obstructive sleep apnea syndrome to treat snoring. 17 They have found good results in OSAS patients as well thereby increasing the scope of this sclerotherapy in OSAS also.…”

Section: Discussionmentioning

confidence: 95%

Analysing the efficacy of polidocanol in injection snoreplasty

Manjunath

Singh

Rao

et al. 2020

Int J Otorhinolaryngol Head Neck Surg

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Background: Injection snoreplasty was recently introduced as a safe, effective, and minimally invasive treatment for primary snoring. The objective of the study was to assess the effectiveness of the treatment in our patients.Methods: The study was a prospective, non-randomised study done on 40 patients with primary snoring. Study was done in the Department of Otorhinolaryngology and Head and Neck Surgery at Basaveshwara Medical College and Hospital, Chitradurga over 8 months between March 2019 to October 2019. The data was collected from patients about their symptoms. Detailed clinical and radiological examination was done in all patients. Almost each and every causes of snoring were ruled out. 1-3% polidocanol injection of about 1 ml with insulin syringe was administered in all the patients in 1 to 3 sittings after 10% LOX spray application on the site. Patients were assessed after 1, 3 and 6 months and their improvement was noted. Results: There were 24 (60%) males and 16 (40%) females enrolled in our study with mean age as 42±5 years. The average BMI of patients was 27.14±3.1 kg/m2. All the patients except 4 were initially injected 1% polidocanol injection; the others were injected 3%. 4 (10%) patients were re-injected at 1 month and 4 (10%) had 2nd re-injection at 3 months follow up. The mean improvement in symptoms was 58%. Eleven patients (27.5%) had moderate snoring while the rest had severe snoring. The only side effect was pain which in majority of patients was mild. There was no correlation between BMI and percentage of improvement.Conclusions: Injection snoreplasty is a safe and cost-effective treatment for primary snoring.

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Section: Discussionmentioning

confidence: 95%

Analysing the efficacy of polidocanol in injection snoreplasty

Manjunath

Singh

Rao

et al. 2020

Int J Otorhinolaryngol Head Neck Surg

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“…Obstructive sleep apnea syndrome (OSAS) diagnosis is a complex issue in sleep medicine, and it should always include its common symptoms: snoring, excessive daytime somnolence, asthenia, poor work performance, the history of stroke or arterial hypertension and a polysomnography. Its treatment is complex as well; it may include surgery or medical approaches, being the use of continuous positive airway pressure (CPAP) the gold standard 1 .…”

Section: Introductionmentioning

confidence: 99%

Nocturia as a clinical indicator of severe obstructive sleep apnea syndrome and its response to CPAP or surgical treatment

Labra¹,

Roldan-Navarro²,

Haro-Valencia³

et al. 2022

Sleep Sci

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Introduction:Obstructive sleep apnea syndrome (OSAS) is a common condition that has been associated to a number of metabolic, cardiovascular and cognitive consequences. Its diagnosis relies on a polysomnographic or polygraphic study, but clinical findings remain as an important part of the diagnostic process. Nocturia is a common symptom that may indicate severe OSAS, but it is often forgotten in the initial evaluation of these kind of patients. Positive airway pressure (CPAP) is known to reduce nocturia, but the roll of surgery is not clear about it. Material and Methods: A case series is presented. We compare 2 groups of male adults with severe OSAS, the first group treated with CPAP for 3 months, while group 2 underwent a multilevel surgical management. Apnea-hypopnea index (AHI) and the nocturia events number (NEN) were assessed before and after the treatment. Frequencies, descriptive statistics and a related sample Student's t-test were performed for statistical analysis. Results: 97 male patients were included, age ranged from 29 to 71 years old. In group 1, treated with CPAP, AHI mean was 54.59 and nocturia mean 4.53 before treatment. With CPAP, the AHI mean was 6.63 and NEN mean 0.51. In group 2, AHI mean before surgery was 40.02, NEN mean 3.78, and after the surgical management AHI mean was 7.74 and NEN mean 0.7. Student's t-test in groups 1 and 2 showed a p=0.000. Conclusions: AHI and NEN were clearly related in both groups, and the improvement of NEN and AHI were consistent in both groups, the CPAP and the surgical treatment. The presence of a NEN value of 4-5 may be an indicator of severe OSAS and should always be clinically evaluated.

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“…Many studies have appeared in the last 15–20 years on the efficacy of these stronger agents in soft tissue (including knee ligaments,12–14 elbow ligaments,15–18 shoulder rotator cuff insertions,19 fauces (for snoring and obstructive sleep apnoea)20 21 and dislocating temporomandibular joints (TMJ)) 22. Our clinic gave up on dextrose many years ago, even as a back-up for those with allergies to stronger agents, due to its lack of efficacy.…”

Section: Introductionmentioning

confidence: 99%

Comparison of tetradecyl sulfate versus polidocanol injections for stabilisation of joints that regularly dislocate in an Ehlers-Danlos population

Burling¹

2019

BMJ Open Sport Exerc Med

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ObjectivesTo determine whether there is similarity between tetradecyl sulfate and polidocanol in stabilising a joint from dislocating in patients with Ehlers-Danlos syndrome (EDS).MethodA retrospective analysis of patients with EDS in a sole-practice clinic in New Zealand. Patients must have had the diagnosis of EDS, had easily dislocatable joints, had treatment and at least 3 months’ follow-up. 0.11% tetradecyl sulfate solution, or 0.25% polidocanol solution, was injected to ligament attachments (enthesis) on the side of the joints where they dislocated. Patients were deemed successfully treated if their affected joints were no longer dislocated over a minimum of 3 months’ follow-up (out to 3 years).ResultsOf 250 patients at the time of the study, 46 fitted the criteria. There were 37 treated with tetradecyl sulfate and nine with polidocanol. For the tetradecyl group there were a total of 305 injections around 97 joints: mean 3.1, range 1–22, median 2. For the polidocanol group there were 36 injections around 19 joints: mean 1.9, range 1–8, median 2. The difference of means between group 1 (tetradecyl) and group 2 (polidocanol) is 1.2, CIs 0.34 to 2.98. All patients had no further dislocations of treated joints unless they had a major new injury (two patients).ConclusionThere was no difference between the two groups for stabilising joints from dislocating. These two agents appear promising for treating patients with recurrent joint dislocations in the setting of EDS. Prospective multicentre randomised controlled trials are needed to confirm these data.

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Efficacy of Submucosal Sodium Tetradecyl Sulfate in the Soft Palate as a Treatment of the Mild Obstructive Sleep Apnea Syndrome: A Pilot Study

Cited by 7 publications

References 10 publications

Analysing the efficacy of polidocanol in injection snoreplasty

Analysing the efficacy of polidocanol in injection snoreplasty

Nocturia as a clinical indicator of severe obstructive sleep apnea syndrome and its response to CPAP or surgical treatment

Comparison of tetradecyl sulfate versus polidocanol injections for stabilisation of joints that regularly dislocate in an Ehlers-Danlos population

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