Efficacy of subcutaneous interferon-beta in COVID-19: a meta-analysis and systematic review

Asif, Abuzar A; Hussain, Habiba; Kumaran, Sriviji Senthil; Syed, Salman; Vanka, Varun; Tharoor, Manisha; Rangwala, Umme Salma; Rathore, Urvashi; Singhal, Malay; Chatterjee, Tulika

doi:10.1080/20009666.2021.1984644

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Sars-cov-2 and The Immune System1

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2022

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“…As such, interferons are not recommended in unwell SARS-CoV-2 patients. [ 35 , 36 ]. Due to perturbations in antiviral immunity in the setting of SARS-CoV-2, disseminated infection can occur with simultaneous activation of multiple components of the innate and adaptive immune system.…”

Section: Sars-cov-2 and The Immune Systemmentioning

confidence: 99%

SARS-CoV-2 Associated Immune Dysregulation and COVID-Associated Pulmonary Aspergilliosis (CAPA): A Cautionary Tale

Worku

2022

IJMS

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As the global SARS-CoV-2 pandemic continues to plague healthcare systems, it has become clear that opportunistic pathogens cause a considerable proportion of SARS-CoV-2-associated mortality and morbidity cases. Of these, Covid-Associated Pulmonary Aspergilliosis (CAPA) is a major concern with evidence that it occurs in the absence of traditional risk factors such as neutropenia and is diagnostically challenging for the attending physician. In this review, we focus on the immunopathology of SARS-CoV-2 and how this potentiates CAPA through dysregulation of local and systemic immunity as well as the unintended consequences of approved COVID treatments including corticosteroids and IL-6 inhibitors. Finally, we will consider how knowledge of the above may aid in the diagnosis of CAPA using current diagnostics and what treatment should be instituted in probable and confirmed cases.

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Section: Sars-cov-2 and The Immune Systemmentioning

confidence: 99%

SARS-CoV-2 Associated Immune Dysregulation and COVID-Associated Pulmonary Aspergilliosis (CAPA): A Cautionary Tale

Worku

2022

IJMS

View full text Add to dashboard Cite

show abstract

Efficacy of subcutaneous interferon-beta in COVID-19: a meta-analysis and systematic review

Cited by 1 publication

References 19 publications

SARS-CoV-2 Associated Immune Dysregulation and COVID-Associated Pulmonary Aspergilliosis (CAPA): A Cautionary Tale

SARS-CoV-2 Associated Immune Dysregulation and COVID-Associated Pulmonary Aspergilliosis (CAPA): A Cautionary Tale

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