Efficacy of Stereotactic Conformal Radiotherapy vs Conventional Radiotherapy on Benign and Low-Grade Brain Tumors

Abstract

clinicaltrials.gov Identifier: NCT00517959.

Childhood cancer survivorship and late effects: The landscape in India in 2020

“…Despite the above limitations, several important observations can be made. These studies confirmed some of the well‐documented issues in childhood cancer survivors including the previously reported detrimental effects of cranial radiation on neurocognition 10‐13 and neuroendocrine axis, 12 of neck radiation on thyroid function, 8,11 and of alkylating agents on fertility 11,13,25,26 . Contrary to published literature, 29 a single study from India showed that bone mineral density in leukemia survivors was similar to that of controls 23 .…”

“…A summary of results of 21 studies 8‐28 is tabulated (Supporting Information Table 1) and categorized by organ systems and late effects as used in the Children's Oncology Group Survivorship Guidelines 29 . All except one 8 of these studies have been published in the last decade, highlighting the recent expansion in work in this area in India.…”

“…Most studies lacked controls, 8‐15,18‐22,24‐28 which is important to quantify the increased risk of the problem as compared with the general population. Importantly, with few exceptions, 10,12,25 most studies had not examined dose‐effect relationship of exposure or the effect of combined modality of treatment. Heterogeneity in methodology (of patient selection, defining outcomes, and tools used) made it unfeasible to pool data and give a summative risk for each category.…”

Postoperative Long-term Outcomes of Patient with Craniopharyngioma Based on CyberKnife Treatment

“…In this situation, hypofractionated radiotherapy was found to yield favorable treatment outcomes. However, frequent administration of the therapy, long treatment duration, and the possible occurrence of adverse events were the problems identified [20]. Since CyberKnife was introduced as a representative treatment device for stereotactic radiotherapy, extremely favorable outcomes and low incidence of adverse events have been reported [12].…”

Proton therapy for selected low grade glioma patients in the Netherlands

“…Advanced radiotherapy techniques with overall less radiation exposure to the brain (dose and volume reduction) compared to more conventional techniques improve neurocognitive outcome. This has been shown for photon techniques in patients with brain metastases and low grade brain tumours [80,82], as well as proton versus photon techniques in paediatric brain tumour patients [83,84]. The hippocampi are a relevant subvolume of the brain for NCF endpoints.…”