Efficacy of stem cell-based therapies for colistin-induced nephrotoxicity

Gergin, Özlem Öz; Pehlivan, Sibel Seçkin; ULGER, Menekse; Mat, Ozge Cengiz; Bayram, Adnan; Gönen, Zeynep Burçin; GÖKDEMİR, Nur Seda; Biçer, Cihangir; Yildiz, Karamehmet; Yay, Arzu

doi:10.1016/j.etap.2022.103933

Cited by 2 publications

(1 citation statement)

References 56 publications

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“…In addition, autophagy is active in the physiological state or can be activated by cellular stresses such as oxidative stress 145 . Gergin et al 146 demonstrated that transplanted MSCs inhibited oxidative stress in colistin-induced nephrotoxicity by modulating autophagy. Autophagy and oxidative stress are correlated, and the underlying mechanisms of MSCs-based treatment have not been fully explored.…”

Section: Efficacy and Mechanisms Of Mscs Therapy In Kdmentioning

confidence: 99%

Mesenchymal Stem Cell Therapy in Kidney Diseases: Potential and Challenges

Chen

Xia

et al. 2023

Cell Transplant

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Kidney disease (KD) is a life-threatening disease characterized by high morbidity and mortality in clinical settings, which can be caused by many reasons, and the incidence increases with age. However, supportive therapy and kidney transplantation still have limitations in alleviating KD progression. Recently, mesenchymal stem cells (MSCs) have shown great potential in repairing injury through their multidirectional differentiation and self-renewal ability. Of note, MSCs serve as a safe and effective therapeutic strategy for treating KD in preclinical and clinical trials. Functionally, MSCs ameliorate KD progression by regulating the immune response, renal tubular cell apoptosis, tubular epithelial–mesenchymal transition, oxidative stress, angiogenesis, and so on. In addition, MSCs exhibit remarkable efficacy in both acute kidney injury (AKI) and chronic kidney disease (CKD) through paracrine mechanisms. In this review, we outline the biological characteristics of MSCs, discuss the efficacy and mechanisms of MSCs-based therapy for KD, summarize the completed and ongoing clinical trials, as well as analyze limitations and new strategies, aiming to provide new ideas and approaches for the preclinical experiments and clinical trials of MSCs transplantation for KD.

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Section: Efficacy and Mechanisms Of Mscs Therapy In Kdmentioning

confidence: 99%