Efficacy of sporicidal wipes for inactivation of a <i>Bacillus anthracis</i>
 surrogate

Meyer, Kathryn M.; Tufts, Jenia A. M.; Calfee, M. Worth; Oudejans, L.

doi:10.1111/jam.12648

Cited by 5 publications

(5 citation statements)

References 28 publications

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“…Leggett et al confirmed the synergistic activity of the combination of PAA and HP via suspension tests using B. subtilis spores, and hypothesized that aqueous HP weakens the spore coat, but that inactivation is primarily due to PAA. As noted in Table , spray-applied formulations of PAA (0.08–0.5 wt %) were effective against B. anthracis on several indoor and outdoor building materials, but notably ineffective on unpainted concrete. ,,, PAA has also been evaluated via application with wipes and fog . In a comprehensive study, fogging of PAA (and also aqueous HP) was found to be effective on most of the subway railcar materials that were tested, in at least one of the conditions evaluated .…”

Section: Liquid-based Sporicidesmentioning

confidence: 96%

Review of Decontamination Techniques for the Inactivation of Bacillus anthracis and Other Spore-Forming Bacteria Associated with Building or Outdoor Materials

Wood

Adrion

2019

Environ. Sci. Technol.

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Since the intentional release of Bacillus anthracis spores through the U.S. Postal Service in the fall of 2001, research and development related to decontamination for this biological agent have increased substantially. This review synthesizes the advances made relative to B. anthracis spore decontamination science and technology since approximately 2002, referencing the open scientific literature and publicly available, well-documented scientific reports. In the process of conducting this review, scientific knowledge gaps have also been identified. This review focuses primarily on techniques that are commercially available and that could potentially be used in the large-scale decontamination of buildings and other structures, as well as outdoor environments. Since 2002, the body of scientific data related to decontamination and microbial sterilization has grown substantially, especially in terms of quantifying decontamination effcacy as a function of several factors. Specifically, progress has been made in understanding how decontaminant chemistry, the materials the microorganisms are associated with, environmental factors, and microbiological methods quantitatively impact spore inactivation. While advancement has been made in the past 15 years to further the state of the science in the inactivation of bacterial spores in a decontamination scenario, further research is warranted to close the scientific gaps that remain.

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Section: Liquid-based Sporicidesmentioning

confidence: 96%

Review of Decontamination Techniques for the Inactivation of Bacillus anthracis and Other Spore-Forming Bacteria Associated with Building or Outdoor Materials

Wood

Adrion

2019

Environ. Sci. Technol.

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“…There is a growing body of evidence demonstrating the importance of environment contamination in the transmission of clinically relevant pathogens. 5,6 Although multiple studies have investigated the efficacy of microfiber cloths [7][8][9] and antimicrobial wipes, [10][11][12][13][14][15][16] to the best of our knowledge no study has yet investigated the efficacy of detergent wipes. Although it has been suggested that a 1 wipe, 1 surface, 1 direction approach be implemented, in practice a wipe (detergent-or disinfectant-based) is likely to be used on multiple surfaces.…”

mentioning

confidence: 99%

Pathogen transfer and high variability in pathogen removal by detergent wipes

Ramm¹,

Siani²,

Wesgate³

et al. 2015

American Journal of Infection Control

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“…Previously, sporicidal wipes were shown to be effective on numerous material types, such as stainless steel, glass, composite epoxy, painted drywall, and low-density polyethylene plastic. [30] …”

Section: Discussionmentioning

confidence: 99%

“…These results corroborate previous studies that demonstrated the effectiveness of wipe-based surface decontamination approaches on steel, glass, composite epoxy, dry wall, and low-density polyethylene. [30,43] Wipe-based sample container decontamination procedures are also more feasible to conduct in restrictive protective gear, and take less time to execute. These factors (time and ease of use) weigh heavily on method selection for real-world response operations.…”

Section: Discussionmentioning

confidence: 99%

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Evaluation of standardized sample collection, packaging, and decontamination procedures to assess cross-contamination potential duringBacillus anthracisincident response operations

Calfee

Tufts

Meyer

et al. 2016

Journal of Occupational and Environmental Hygiene

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Sample collection procedures and primary receptacle (sample container and bag) decontamination methods should prevent contaminant transfer between contaminated and non-contaminated surfaces and areas during bio-incident operations. Cross-contamination of personnel, equipment, or sample containers may result in the exfiltration of biological agent from the exclusion (hot) zone and have unintended negative consequences on response resources, activities and outcomes. The current study was designed to: (1) evaluate currently recommended sample collection and packaging procedures to identify procedural steps that may increase the likelihood of spore exfiltration or contaminant transfer; (2) evaluate the efficacy of currently recommended primary receptacle decontamination procedures; and (3) evaluate the efficacy of outer packaging decontamination methods. Wet- and dry-deposited fluorescent tracer powder was used in contaminant transfer tests to qualitatively evaluate the currently-recommended sample collection procedures. Bacillus atrophaeus spores, a surrogate for Bacillus anthracis, were used to evaluate the efficacy of spray- and wipe-based decontamination procedures. Both decontamination procedures were quantitatively evaluated on three types of sample packaging materials (corrugated fiberboard, polystyrene foam, and polyethylene plastic), and two contamination mechanisms (wet or dry inoculums). Contaminant transfer results suggested that size-appropriate gloves should be worn by personnel, templates should not be taped to or removed from surfaces, and primary receptacles should be selected carefully. The decontamination tests indicated that wipe-based decontamination procedures may be more effective than spray-based procedures; efficacy was not influenced by material type but was affected by the inoculation method. Incomplete surface decontamination was observed in all tests with dry inoculums. This study provides a foundation for optimizing current B. anthracis response procedures to minimize contaminant exfiltration.

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Efficacy of sporicidal wipes for inactivation of a Bacillus anthracis surrogate

Abstract: These data show the potential of sporicidal wipes for decontamination of small, contained areas of biological contamination and may help on-scene coordinators develop remediation plans following a biological terrorism event.

Cited by 5 publications

References 28 publications

Review of Decontamination Techniques for the Inactivation of Bacillus anthracis and Other Spore-Forming Bacteria Associated with Building or Outdoor Materials

Review of Decontamination Techniques for the Inactivation of Bacillus anthracis and Other Spore-Forming Bacteria Associated with Building or Outdoor Materials

Pathogen transfer and high variability in pathogen removal by detergent wipes

Evaluation of standardized sample collection, packaging, and decontamination procedures to assess cross-contamination potential duringBacillus anthracisincident response operations

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