Efficacy of soy protein concentrate replacing animal protein supplements in mucosa-associated microbiota, intestinal health, and growth performance of nursery pigs

Deng, Zixiao; Duarte, Marcos Elias; Kim, Sung Woo

doi:10.1016/j.aninu.2023.06.007

Cited by 7 publications

(4 citation statements)

References 65 publications

(81 reference statements)

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“…Numerous studies have shown that plant proteins have a regulatory effect on intestinal flora. 42 Beneficial bacteria promote good health by strengthening the immune system, 43 improving digestion and absorption, 44 producing vitamins, inhibiting the growth of potential pathogens 45 and preventing the feeling of gas and bloating. 46 However, harmful bacteria make carcinogens, decay proteins in the gut, produce toxins, and disrupt our intestinal functioning, leading to bacterial infections and diseases.…”

Section: Discussionmentioning

confidence: 99%

Modulation of cecal microbiota and fecal metabolism in mice by walnut protein

Si,

Yan,

Jun

et al. 2024

Food Funct.

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Section: Discussionmentioning

confidence: 99%

Modulation of cecal microbiota and fecal metabolism in mice by walnut protein

Si,

Yan,

Jun

et al. 2024

Food Funct.

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“…Increasing supplemental levels of β-mannanase linearly reduced TNF-α, IgG, MDA, and PC both in the duodenum and the jejunum of nursery pigs. The TNF-α, a pro-inflammatory cytokine, along with IgG, an immunoglobulin, are key mediators of inflammatory response, and MDA and PC are products of oxidative damage ( Duarte and Kim, 2022 ; Deng et al., 2023b ; Jang et al., 2023b ). Previous studies have shown that the decreases in TNF-α and IgG ( Holanda and Kim, 2022 ; Deng et al., 2023a ) and MDA and PC ( Chen et al.…”

Section: Discussionmentioning

confidence: 99%

Effects of β-mannanase supplementation on intestinal health and growth of nursery pigs

Jang,

Kim,

Duarte

et al. 2024

Journal of Animal Science

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Two experiments were conducted using 120 pigs to test the hypothesis that supplementation of β-mannanase could reduce digesta viscosity, enhance nutrient digestion, and improve intestinal health and growth of nursery pigs. In Exp. 1, 48 crossbred barrows were randomly allotted to four treatments with increasing levels of β-mannanase at 0, 200, 400, and 600 unit (U)/kg in feeds. All pigs were euthanized on d 12 to collect jejunal digesta to measure digesta viscosity and ileal digesta to measure apparent ileal digestibility (AID) of dry matter (DM), gross energy (GE), neutral detergent fiber (NDF), and acid detergent fiber (ADF). In Exp. 2, 72 nursery pigs were randomly allotted to three treatments with increasing levels of β-mannanase at 0, 400, and 600 unit (U)/kg in feeds. Plasma collected on d 9 was used to measure tumor necrosis factor-α (TNF-α), immunoglobulin G (IgG), malondialdehyde (MDA), and protein carbonyl (PC). All pigs were euthanized on d 10 to collect duodenal and jejunal tissues to evaluate the production of TNF-α, IL-6, and MDA, morphology, crypt cell proliferation, and expression of tight junction proteins in the jejunum. Data were analyzed using the MIXED procedure for polynomial contrasts and the NLMIXED procedure for broken line analysis of SAS. In Exp. 1, β-mannanase supplementation tended to have quadratic effects on digesta viscosity (P = 0.085) and AID of GE (P = 0.093) in the pigs. In Exp. 2, jejunal digesta viscosity of the pigs was reduced (P < 0.05) when β-mannanase was supplemented at 360 U/kg of feed. β-mannanase supplementation linearly reduced (P < 0.05) TNF-α, IgG, MDA, and PC in the duodenum, and TNF-α, IgG, and MDA in the jejunum of the pigs. β-mannanase supplementation linearly increased (P < 0.05) villus height to crypt depth ratio and crypt cell proliferation in the jejunum. β-mannanase supplementation tended to linearly improve (P = 0.083) expression of ZO-1 in the jejunum. In conclusion, supplementation of β-mannanase at 360 U/kg reduced the digesta viscosity and up to 600 U/kg positively affected intestinal health and growth of pigs by reducing inflammation and oxidative stress whilst enhancing structure and barrier function in the jejunum.

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“…Pig nutrition and production research largely focuses on nursery pigs. This is due to the complications associated with weaning, as nursery pigs are weaned at an early age when the gastrointestinal tract is not fully mature and able to handle the typical feedstuffs provided to them [16][17][18]. When the presentations were grouped by the major research subject matter, research related to classical nutrition and productivity took the largest portion (63%, 185 presentations).…”

Section: Pig Production and Advances In Researchmentioning

confidence: 99%

— Invited Review — Current status of global pig production: an overview and research trends

Kim,

Gormley,

Jang

et al. 2024

Anim Biosci

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Global pig production has increased by 140% since the 1960s. The increase in global population, coupled with improving socioeconomic conditions of many countries has led to an increased consumption of meat globally, including pork. To keep up with demand and capitalize on economic opportunities, the countries of China, the United States (US), and the European Union (EU) have become the top 3 pork producers globally. China is of particular interest, as it is the both the largest country in pork production and pig numbers, as well as being the largest importer of pork from other countries. Globally, the efficiency of pork production has improved, in relation to the integration of pig production and the dramatic increase in research efforts in pig nutrition and production. Through integration, large producers can consolidate resources and maximize profits and efficiency. The increased research interest and efforts in pig production have given scientists and producers the opportunity to collaborate to adapt to challenges and identify possible solutions to issues brought on by a volatile global market. Intestinal health (23%), general nutrition and growth (23%), and amino acid nutrition (15%) were the top 3 areas (61%) leading research trends in pig nutrition and production. Major dietary interventions with feed additives evaluated include functional amino acids, feed enzymes, pre-/pro-/post-biotics, and phytobiotics with a common goal to improve the growth efficiency by enhancing nutrient utilization and intestinal health. With increasing global issues with environment, pig producers and the supporting scientists should continue their efforts to improve the production efficiency and to reduce the environmental footprint from pig production.

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Efficacy of soy protein concentrate replacing animal protein supplements in mucosa-associated microbiota, intestinal health, and growth performance of nursery pigs

Cited by 7 publications

References 65 publications

Modulation of cecal microbiota and fecal metabolism in mice by walnut protein

Modulation of cecal microbiota and fecal metabolism in mice by walnut protein

Effects of β-mannanase supplementation on intestinal health and growth of nursery pigs

— Invited Review — Current status of global pig production: an overview and research trends

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