Efficacy of silymarin-phospholipid complex in reducing the toxicity of aflatoxin B1 in broiler chicks

Tedesco, D.; Steidler, Stephanie; Galletti, S.; Tameni, M.; Sonzogni, O.; Ravarotto, Licia

doi:10.1093/ps/83.11.1839

Cited by 176 publications

(156 citation statements)

References 30 publications

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“…It is anticipated that the effective and valuable relevance of the natural products and herbal remedies being applied with the nano carrier will enhance the significance of existing drug delivery systems. [11,12,19,31] …”

Section: Resultsmentioning

confidence: 99%

“…[9][10][11][12] There are many of the herbal products and their derived constituents present in the market are: Lovastatin (anticholesterolemic), [13] paclitaxol, doxorubicin (both anticancer drugs), cyclosporine-A and tacrolimus (both immunosuppressive), [14,15] erythromycin, streptomycin, rafamycin (all antibiotics), and amphotericin-B (fungicidal). Actually, with respect to the conventional pharmaceuticals, these drugs have their existence from natural remedies.…”

Section: Review Articlementioning

confidence: 99%

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Tapadiya¹

2017

IJGP

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Natural herbs are moving from fringe to mainstream use with a increase number of population-seeking remedies and health approaches free from hazardous side effects caused by laboratory synthesize chemicals. Recently, focus has been given to utilize eco-friendly and bio-friendly natural-based products for the prevention and cure of diseases. It is documented that 80% of the world's population has belief in natural medicine, particularly plant-based drugs for their primary healthcare. Herbal drug generally introduce in the market in traditional dosage form but now different scientific approaches are being developed these days to deliver herbal medicines due to their poor rate of absorption and target specific approach. Novel drug delivery systems including nanoparticles have been developed for the effective delivery of herbal drugs. Nanoparticulate formulations such as liposomes, polymeric nanoparticles, microemulsions, proliposomes, and solid lipid nanoparticles present potential to deliver herbal medicines effectively. Because of nanotechnology, the use of herbal drug is greatly increased in recent years. In this article, we are try to elaborating the role of nanotechnology which increases the potential as well as sale of herbal drugs in global world.

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Section: Resultsmentioning

confidence: 99%

Section: Review Articlementioning

confidence: 99%

Untitled

Tapadiya¹

2017

IJGP

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“…Many studies have shown that AFB 1 exposure can lead to a reduction in weight gain in broiler chicks in a dose-and time-dependent manner (Valdivia et al, 2001;Tedesco et al, 2004;Zhao et al, 2010;Peng et al, 2014b;Fowler et al, 2015). Diaz et al (2008) proposed a biphasic nature (hormesis) of aflatoxins on the broiler's weight gain, i.e.…”

Section: Discussionmentioning

confidence: 99%

Biochemical and Histopathological Study of Aflatoxicosis on Ross 308 Broiler Chicks

Ko¹,

Ahn²,

Shin³

et al. 2017

Korean J. Poult. Sci.

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Totally, one hundred and sixty 1-day-old Ross 308 broiler chicks were fed with a diet containing 0, 0.5, 1.0, and 2.0 mg of aflatoxin B 1 (AFB 1 )/kg of feed for 21 days. Body weight was lower for the AFB 1 -treated broilers than for the control group. At 14 and 21 DPF, the broilers fed with 2.0 mg of AFB 1 /kg of feed weighed significantly lower than those of the other groups (p<0.05). Relative liver weights increased significantly in a dose-dependent manner, and relative spleen weights were significantly high in the chicks fed with 2.0 mg of AFB 1 /kg of feed at 21 DPF (p<0.001). Biochemical analyses showed that total protein and albumin levels decreased significantly at 7 and 14 DPF for the chicks of the group fed with 2.0 of mg AFB 1 /kg of feed, compared with those fed with 0.5 and 1.0 mg of AFB 1 /kg of feed (p<0.05). AST and ALT levels increased significantly at 14 and 21 DPF (p<0.05), and the AST levels, particularly, increased dose-dependently (p<0.05). Histopathological analyses showed that the liver tissues of the AFB 1 -treated chicks showed significant lesions, including hemorrhage, hepatocyte necrosis, inflammatory cell infiltration, and fatty degeneration. The severity of both hepatocyte necrosis and inflammatory cell infiltration appeared to increase dose-and time-dependently. Similarly, hepatic fibrosis increased dosedependently (p<0.05). The results of this study could improve our understanding of parameters used for evaluating aflatoxicosis in poultry.

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“…e. The phytosomes from standardized extract of seeds of S. marianum have administered orally which is having great effect on foetus from maternally ingested alcohol [64]. f. One clinical research reveals that the study of 232 patient with chronic hepatitis when treated with silybin phytosome at a dose of 120 mg twice or thrice a day up to 120 days having great role for recovery of liver function [63]. g. Grape seed phytosome also having great role in ischemia induced damage in the heart, also having protective against atherosclerosis.…”

Section: Advances In Phytosome Technologymentioning

confidence: 99%

A Review on Phytosomes: Novel Approach for Herbal Phytochemicals

Kumar

Singh

et al. 2017

Asian J Pharm Clin Res

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The poor oral bioavailability of polyphenolic compound can be enhanced through the incorporation of them into phospholipid based self-assembled delivery system, i.e. popularly known as phytosome. "Phyto" means plants and "some" resembles a covering around/or a structure. Phytosome is generally prepared by reacting one or two moles of polyphenolic phytoconstituents and phospholipid. It may be either in the ratio of 1:1 and 1:2. By using phytosomes, one can also achieve enhanced rate and extent of the passage of lipophilic herbal constituents across lipid membrane that explains its character as a carrier as well as acid labile herbal drugs could also be protected in gastrointestinal tract. There are number of products available in the market that contains phytosomal drug delivery system such as Ginkgo biloba, Silybum marianum, and Camellia sinensis. The present review describes an updated overview of preparation of phytosomes, advancement in phytosomes technology, various herbal drugs for which phytosomes have been used as a carrier, its commercial availability and applications.

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Efficacy of silymarin-phospholipid complex in reducing the toxicity of aflatoxin B1 in broiler chicks

Cited by 176 publications

References 30 publications

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Biochemical and Histopathological Study of Aflatoxicosis on Ross 308 Broiler Chicks

A Review on Phytosomes: Novel Approach for Herbal Phytochemicals

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