Efficacy of short‐term dexamethasone therapy in acute‐on‐chronic pre‐liver failure

Abstract

Five-day dexamethasone therapy is effective in improving the liver function and survival rate of patients with pre-ACLF.

Determinants of the clinical outcome of patients with severe acute exacerbation of chronic hepatitis B virus infection

“…Whatever the mechanism of AE, a few weeks are needed for sufficient suppression of the production of HBV-related proteins by preventing HBV replication even when NAs are used [40]. Thus, earlier introduction of CS in combination with potent antiviral therapy is a reasonable approach for the initial treatment of AE to prevent excessive immunological reactions and progression of liver cell injury [22,41]. NA or CS used on its own has limits in the resolution of the serious conditions.…”

Evaluation of the efficacy of steroid therapy on acute liver failure

“…Corticosteroids have several other hepatoprotective roles, including preventing cytolysis of ballooned hepatocytes and protecting hepatocytes against apoptosis induced by cadmium toxicity (12)(13)(14). Previous work by the present authors and other groups has revealed that corticosteroids are effective in treating pre-acute-on-chronic liver failure (pre-ACLF) associated with HBV and severe acute exacerbation (SAE) of chronic hepatitis B (15)(16)(17). Therefore, treating ALF and SALF with corticosteroids is a reasonable treatment regimen.…”

Glucocorticoids can increase the survival rate of patients with severe viral hepatitis B

“…All articles discussed the effect of glucocorticoid on the survival rate. Five studies discussed the effect of glucocorticoids on TBIL [24,[26][27][28][29]. Four studies discussed the effect of glucocorticoid on PTA [24,[26][27][28].…”

“…The design and results of the two studies were available in their abstract. Four studies [3,[27][28][29] focused on preliver failure and four [24][25][26]30] examined liver failure. All studies compared glucocorticoid therapy with routine medical treatment and observation occurred for more than 4 weeks.…”

“…A total of 216 articles were associated with glucocorticoid treatment of severe hepatitis B, of which eight were included in our study after checking the documents [3,[24][25][26][27][28][29][30] (Fig. 1).…”