Efficacy of Shear Wave Elastography in the Differentiation of Acute and Subacute Deep Venous Thrombosis

Durmaz, Fatma; Gültekin, Mehmet

doi:10.1097/ruq.0000000000000563

Cited by 9 publications

(12 citation statements)

References 42 publications

(71 reference statements)

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“…Sample ages examined here ranged from 1 to 30 days, with an average and standard deviation of 12.2 ± 9.8 days. The average elastic modulus may also not be a good metric because of sample inhomogeneity, though similar degrees of inhomogeneity is observed for clinical scans of DVT 77 , 78 . Ultrasound images are inherently two-dimensional, and volumetric assessment of the sample stiffness may provide a more applicable comparison to bulk measurements such as mass loss.…”

Section: Discussionmentioning

confidence: 96%

Assessment of histological characteristics, imaging markers, and rt-PA susceptibility of ex vivo venous thrombi

Hendley

Dimov

Bhargava

et al. 2021

Sci Rep

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Venous thromboembolism is a significant source of morbidity and mortality worldwide. Catheter-directed thrombolytics is the primary treatment used to relieve critical obstructions, though its efficacy varies based on the thrombus composition. Non-responsive portions of the specimen often remain in situ, which prohibits mechanistic investigation of lytic resistance or the development of diagnostic indicators for treatment outcomes. In this study, thrombus samples extracted from venous thromboembolism patients were analyzed ex vivo to determine their histological properties, susceptibility to lytic therapy, and imaging characteristics. A wide range of thrombus morphologies were observed, with a dependence on age and etymology of the specimen. Fibrinolytic inhibitors including PAI-1, alpha 2-antiplasmin, and TAFI were present in samples, which may contribute to the response venous thrombi to catheter-directed thrombolytics. Finally, a weak but significant correlation was observed between the response of the sample to lytic drug and its magnetic microstructure assessed with a quantitative MRI sequence. These findings highlight the myriad of changes in venous thrombi that may promote lytic resistance, and imaging metrics that correlate with treatment outcomes.

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Section: Discussionmentioning

confidence: 96%

Assessment of histological characteristics, imaging markers, and rt-PA susceptibility of ex vivo venous thrombi

Hendley

Dimov

Bhargava

et al. 2021

Sci Rep

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“…In a study of 50 cases, Durmaz and Gultekin 20 stated that determining the thrombus age plays a critical role in the prescription of a treatment in DVT and found a statistically significant difference between elastography values in the differentiation of acute and subacute thrombus. In our own study, we concluded that medical treatment was successful in acute thrombi with lower SWE values.…”

Section: Discussionmentioning

confidence: 99%

Comparison of Medical Treatment Efficiency With Shear Wave Elastography Values of Thrombus in Patients With Lower Extremity Deep Vein Thrombosis

Ince

Özgökçe

Özkaçmaz

et al. 2023

Ultrasound Quarterly

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In lower-extremity deep vein thrombosis (DVT), thrombus age is essential for successful treatment. The aim of our study was to compare the shear wave elastography (SWE) values measured before treatment and achieved lumen patency after treatment in lower-extremity DVT patients with total occlusion. Patients diagnosed with DVT in the acute-subacute stage (<4 week) with total thrombosis in lower extremity were included in this prospective study. Shear wave elastography measurements were performed where the thrombus was most prominent and homogeneous. To evaluate patient response to treatment, lumen patency (partial [>25%] or total recanalization) was examined using color Doppler imaging in the first and third months posttreatment. Shear wave elastography values with and without patency were compared using an independent t test. Among 75 patients in this study, at the first-month color Doppler imaging examination, the SWE values were 1.77 ± 0.49 (1.09-3.03) m/s in patients who achieved lumen patency (n = 42) and 2.21 ± 0.54 (1.24-3.36) m/s in those who did not show lumen patency (n = 33). The difference between the groups' mean elastography value was statistically significant ( P < 0.001). At the third-month examination, the SWE values were 1.76 ± 0.46 (1.09-3.03) m/s in patients with lumen patency (n = 55) and 2.52 ± 0.48 (1.74-3.36) in patients without lumen patency (n = 20). The difference between the 2 groups' mean elastography value was statistically significant ( P < 0.001). We concluded that it is more difficult to achieve lumen patency in veins occluded by thrombus with higher elasto values, and endovascular interventional procedures should be considered during the initial treatment of high SWE value thrombosis.

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“…Further, using a cutoff value of 2.85, the sensitivity and specificity were 96.3% and 91.3% for acute DVT. 35 However, given the small sample size, further studies are warranted to validate these results.…”

Section: Sonographic Evaluation Of Venous Thrombotic Diseasementioning

confidence: 93%

Noninvasive and invasive imaging of lower-extremity acute and chronic venous thrombotic disease

Li,

Ruff,

Rafailidis

et al. 2023

Vasc Med

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The spectrum of venous thromboembolic (VTE) disease encompasses both acute deep venous thrombosis (DVT) and chronic postthrombotic changes (CPC). A large percentage of acute DVT patients experience recurrent VTE despite adequate anticoagulation, and may progress to CPC. Further, the role of iliocaval venous obstruction (ICVO) in lower-extremity VTE has been increasingly recognized in recent years. Imaging continues to play an important role in both acute and chronic venous disease. Venous duplex ultrasound remains the gold standard for diagnosing acute VTE. However, imaging of CPC is more complex and may involve computed tomography, magnetic resonance, contrast-enhanced ultrasound, or intravascular ultrasound. In this narrative review, we aim to discuss the full spectrum of venous disease imaging for both acute and chronic venous thrombotic disease.

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Efficacy of Shear Wave Elastography in the Differentiation of Acute and Subacute Deep Venous Thrombosis

Cited by 9 publications

References 42 publications

Assessment of histological characteristics, imaging markers, and rt-PA susceptibility of ex vivo venous thrombi

Assessment of histological characteristics, imaging markers, and rt-PA susceptibility of ex vivo venous thrombi

Comparison of Medical Treatment Efficiency With Shear Wave Elastography Values of Thrombus in Patients With Lower Extremity Deep Vein Thrombosis

Noninvasive and invasive imaging of lower-extremity acute and chronic venous thrombotic disease

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