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Intl J Eating Disorders

2004

DOI: 10.1002/eat.20018

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Efficacy of sertraline for bulimia nervosa

Denise M. Sloan

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,

²

,

Craig M. Helbok

³

et al.

Abstract: Findings from the current study indicate that sertraline is efficacious in the treatment of bulimia nervosa. A double-blind controlled trial of sertraline is recommended for future research.

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Cited by 10 publications

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Bulimia nervosa

et al. 2019

S3-Leitlinie Diagnostik Und Behandlung Der Essstörungen

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No abstract

Bulimia nervosa

et al. 2019

S3-Leitlinie Diagnostik Und Behandlung Der Essstörungen

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Serotonin-induced decrease of intracellular Ca2+ release in platelets of bulimic patients normalizes during treatment

¹

,

²

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³

et al. 2008

J Neural Transm

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Numerous symptoms related to eating disorders have been shown to be influenced by serotonergic (5-HT) functioning, with the 5-HT(2A) receptor subtype being one of the most relevant involved in the pathophysiology of bulimia nervosa (BN). In line with this, Ca(2+) mobilization as mediated by 5-HT(2) receptors in platelets was shown to serve as a peripheral model for central nervous 5-HT functioning. Here, the 5-HT-induced intracellular Ca(2+) mobilization in platelets was measured in 13 female normal weight bulimic patients (14-18 years) upon admission and at the end of inpatient treatment. Findings were compared to 21 age-matched healthy female adolescents. 5-HT-induced Ca(2+) release was significantly decreased in bulimic patients upon admission and normalized during inpatient treatment. Antidepressive medication caused a significant improvement. The data provide further evidence that altered 5-HT(2) receptor functioning is involved in the pathophysiological underpinnings in BN.

Pharmacotherapy of eating disorders

¹

,

²

2017

Current Opinion in Psychiatry

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Although pharmacotherapy has established utility in bulimia nervosa and BED, further research on medications for the treatment of eating disorders, particularly anorexia nervosa, is necessary.

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