Efficacy of selective laser trabeculoplasty in primary angle closure disease

Raj, Srishti; Tigari, Basavraj; Faisal, T.T.; Seth, Natasha Gautam; Kaushik, Sushmita; Ichhpujani, Parul; Pandav, Surinder Singh; Ram, Jagat

doi:10.1038/s41433-018-0165-5

Cited by 12 publications

(2 citation statements)

References 23 publications

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“…Both ALT and SLT provided reliable IOP-lowering effect, but ALT caused obvious damage to TM histologically [ 11 , 12 ]. Several clinical trials claimed that SLT was an effective way to control IOP in multiple types of glaucoma [ 13 – 17 ]. However, a wide range of complications, such as redness, photophobia, peripheral anterior synechiae, and cystoid macular oedema were still observed in patients with SLT [ 18 ].…”

Section: Discussionmentioning

confidence: 99%

Micropulse laser trabeculoplasty on Chinese patients with glaucoma or ocular hypertension: average 35 months follow-up results

et al. 2022

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Background Glaucoma is a group of eye diseases that can damage the optic nerve and cause vision loss. A novel technology micropulse laser trabeculoplasty (MLT) can use duty-circle subvisible laser pulses to treat glaucoma. The aim of this study is to evaluate the efficacy of 360° MLT to alleviate intraocular pressure (IOP) in patients with glaucoma. Methods This was a single-center prospective study on patients treated with 360° MLT using a Diode True-Yellow 577-nm Laser with MicroPulse technology. All the patients were recruited from the Department of Ophthalmology. Follow-up visits were carried out at 1 day, 1 week, 1 month, 3 months, 6 months, 18 months, and 36 months after the procedure. Best-corrected visual acuity (BCVA), Intraocular pressure (IOP), and vertical cup-to-disc ratio (C/D ratio) were measured during the follow-up. Repeated-measures analysis of variance (ANOVA) and Kaplan–Meier analysis were performed to evaluate the outcomes. Results A total of 39 eyes from 25 patients were included in this study (10 men/15 women). The average age of patients was 41.47 ± 14.39 years old, and the baseline IOP was 21.13 ± 7.75 mmHg. MLT significantly reduced the IOP at 1 day (range 15.61–19.01, P = 0.0218), 3 months (range 16.47–19.22, P = 0.0390), and 6 months (range 15.38–18.56, P = 0.0332) compared with the baseline. However, by the end of the study, only 21.88% of patients demonstrated a ≥ 20% IOP reduction, while seven eyes needed further laser or surgical treatment. The IOP of glaucoma patients was significantly lower than the ocular hypertension patients at 1 month (P = 0.0124), 3 months (P = 0.0004), 18 months (P = 0.0061) and 36 months (P = 0.0119). Conclusions Micropulse laser trabeculoplasty reduce IOP in patients with glaucoma or ocular hypertension for a short period, but its lowering efficiency is limited up to 6 months of the follow-up period.

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Section: Discussionmentioning

confidence: 99%

Micropulse laser trabeculoplasty on Chinese patients with glaucoma or ocular hypertension: average 35 months follow-up results

et al. 2022

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“…Both ALT and SLT provided reliable IOP-lowering effect, but ALT caused obvious damage to TM histologically (11,12). Several clinical trials claimed that SLT was an effective way to control IOP in multiple types of glaucoma (13)(14)(15)(16)(17). However, a wide range of complications, such as redness, photophobia, peripheral anterior synechiae, and cystoid macular oedema were still observed in patients with SLT (18).…”

Section: Discussionmentioning

confidence: 99%

Micropulse Laser Trabeculoplasty On Glaucoma Patients: Average 35 Months Follow-Up Results

Yang¹,

Huang²,

Liao³

et al. 2021

Preprint

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Background: Glaucoma is a group of eye diseases that can damage the optic nerve and cause vision loss. A novel technology micropulse laser trabecular plasty (MLT) can use duty-circle subvisible laser pulses to treat glaucoma. The aim of this study is to evaluate the efficacy of 360° MLT to alleviate intraocular pressure (IOP) in patients with glaucoma.Methods: This was a single-center prospective study on patients treated with 360° MLT using a Diode True-Yellow 577-nm Laser with MicroPulse technology. All the patients were recruited from the Department of Ophthalmology. Follow-up visits were carried out at 1 day, 1 week, 1 month, 3 months, 6 months, 18 months, and 36 months after the procedure. Best-corrected visual acuity (BCVA), Intraocular pressure (IOP), and vertical cup-to-disc ratio (C/D ratio) were measured during the follow-up. Repeated-measures analysis of variance (ANOVA) and Kaplan–Meier analysis were performed to evaluate the outcomes.Results: A total of 39 eyes from 26 patients were included in this study (10 men/15 women). The average age of patients was 41.47±14.39 years old, and the baseline IOP was 21.13 ± 7.75 mmHg. MLT significantly reduced the IOP at 1 day (range 15.61–19.01, P=0.0218), 3 months (range 16.47–19.22, P=0.0390), and 6 months (range 15.38–18.56, P=0.0332) compared with the baseline. However, by the end of the study, only 21.88% of patients demonstrated a ≥ 20% IOP reduction, while seven eyes needed further laser or surgical treatment. Conclusions: Micropulse laser trabeculoplasty could reduce IOP in patients with glaucoma or ocular hypertension for a short period, but its lowering efficiency was limited up to 6 months of the follow-up period.

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Personalized Management of Physiologic/Ophthalmologic Particularities for Predictive Approach and Targeted Prevention of Primary Angle Closure Glaucoma Applied to Persons at Risk

Kurysheva,

Rodionova,

Pomerantsev

et al. 2024

Advances in Predictive, Preventive and Personalised Medicine

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Efficacy of selective laser trabeculoplasty in primary angle closure disease

Abstract: High baseline IOP significantly correlated with reduction in IOP. Our results suggest that SLT is a safe, cost-effective modality for reducing IOP in primary angle-closure disease with patent laser iridotomy with a visible trabecular meshwork.

Cited by 12 publications

References 23 publications

Micropulse laser trabeculoplasty on Chinese patients with glaucoma or ocular hypertension: average 35 months follow-up results

Micropulse laser trabeculoplasty on Chinese patients with glaucoma or ocular hypertension: average 35 months follow-up results

Micropulse Laser Trabeculoplasty On Glaucoma Patients: Average 35 Months Follow-Up Results

Personalized Management of Physiologic/Ophthalmologic Particularities for Predictive Approach and Targeted Prevention of Primary Angle Closure Glaucoma Applied to Persons at Risk

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