Efficacy of scheduled infliximab maintenance therapy on systemic amyloidosis associated with crohnʼs disease

Inflammatory Bowel Disease and Systemic AA Amyloidosis

“…Treatments have changed over this time period including availability and use of biologic therapy, which has revolutionized treatment of IBD. There have been numerous case reports showing significant improvements in amyloidotic renal dysfunction after anti-TNFa therapy [24,25] and this may explain in part the reduced incidence of amyloidosis associated with CD [17]. Furthermore, some drugs such as 5-aminosalicylates, which were used as the mainstay of treatment in some of the patients with CD in this series, are now considered to be less effective as anti-inflammatory drugs in CD compared to UC [26].…”

Therapeutic effects of biological treatments on AA amyloidosis associated with inflammatory bowel disease: a case report and literature review

“…There are several tools for amyloid typing, including immunofluorescence, immunohistochemistry, immunoelectron microscopy, and proteomic studies [14,46]. Unfortunately, amyloid typing was not used in 11 reported cases [3,23–29,32,35,36,38]. We found that AA amyloidosis may be accompanied by other related disorders beside IBD, such as arthropathy or arthritis, which was the most reported disorder [3,22,26,29,34], FMF [3], or other extraintestinal manifestations [3,34].…”

“…#1 Crohn's Disease 'Crohn Disease'[Mesh] OR Crohn[tiab] OR Crohns[tiab] OR Crohn's[tiab] 65 650 #2Ulcerative colitis 'colitis, ulcerative'[MeSH Terms] OR ulcerative colitis[Text Word] OR colitis[tiab] OR 'ulcerative colitis'[tiab] 89 040 #3 Inflammatory bowel diseases 'inflammatory bowel diseases'[MeSH Terms] OR 'inflammatory bowel disease'[Text Word] OR 'inflammatory bowel disease'[tiab] 118 237 #4 amyloidosis 'amyloidosis'[MeSH Terms] OR amyloidosis[Text Word] OR 'AA amyloidosis'[tiab] OR 'AA-amyloidosis' [tiab]function[3,22,24,25,[27][28][29]31,34,36,37]; additionally, infliximab contributed to patient stability and prevented the progression of proteinuria or renal injury[3,23,30,34,35]; Unfortunately, infliximab failed in a number of cases, which either led to the progression of proteinuria or renal function[3,26,32,34,36,38].…”

Nephrotic Syndrome after Infliximab Treatment in a Patient with Ulcerative Colitis

“…Renal amyloidosis or drug toxicity was discussed to explain this situation. The renal biopsy was negative for amyloidosis and several case reports have described the efficacy of anti-TNF-α treatment on amyloid nephropathy complicating long-standing Crohn's disease, a treatment which induces a rapid response in proteinuria and a suppression of the renal disease activity [1][2][3][4][5][6].…”