Efficacy of Saccharomyces boulardii for treatment of horses with acute enterocolitis

Desrochers, Anne; Dolente, Brett A.; Roy, Marie-France; Boston, Raymond C.; Carlisle, Sharon

doi:10.2460/javma.2005.227.954

Cited by 69 publications

(66 citation statements)

References 22 publications

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“…It proved the survival of S. boulardii in horses with gastrointestinal illness, "demonstrating that it can survive in the gastrointestinal tract of horses with intestinal pathology". However, in contrast to findings by Desrochers et al (2005), it did not prove that the treatment with S. boulardii had any impact on the duration of watery diarrhea.…”

Section: Clinical Studies In Adult Horsescontrasting

confidence: 52%

“…A study on Saccharomyces boulardii administration in horses with acute enterocolitis showed significant decrease in the duration of watery diarrhea and the duration of gastrointestinal illness (Desrochers et al, 2005). In this study 7 horses received the treatment and another 7 received placebo and no difference was found between these two groups in hospitalization duration, recurrence of diarrhea during hospitalization or disease outcome.…”

Section: Clinical Studies In Adult Horsesmentioning

confidence: 76%

“…Most of the studies (Parraga et al, 1997;Kim et al, 2001;Ward et al, 2004;Desrochers et al, 2005) used dosing recommendations given by the product's manufacturer. Assuming that the dosing can be embraced from those used in human medicine, dosing recommendations for horses have been adjusted by weight, although this is not manageable with all commercial probiotic preparations (Weese, 2001).…”

Section: Clinical Studies In Adult Horsesmentioning

confidence: 99%

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The use of Probiotics in Horses with Gastrointestinal Disease

Gotić¹,

Grden²,

Babić³

et al. 2017

American Journal of Animal and Veterinary Sciences

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Probiotics are common adjunctive therapy used in human and veterinary medicine, mostly intended for gastrointestinal diseases treatment or prevention. Lactic acid bacteria: Lactobacilli, bifid bacteria and enterococci and Saccharomyces boulardii, a subtype of the nonpathogenic yeast have been most frequently used as probiotic active ingredients. To become a recognized effective probiotic, a certain microorganism must fulfill many expectations, primarily the ability to survive gastrointestinal tract passage, adhere to epithelial cells and colonize intestines to present antimicrobial effect and inhibition of enteric pathogens. Prior to evaluation of clinical efficiency, it is advised to perform in vitro studies in order to identify potentially beneficial properties of probiotic organisms. An effective probiotic product could be of a great value in equine medicine, since both, adult horses and foals, frequently exhibit gastrointestinal problems. However, very little objective research has been carried out on the topic. The effectiveness of probiotic products in horses has been proven in very few studies and some presented serious adverse effects. Therefore, the benefits of probiotics use in equine medicine still remain undetermined.

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Section: Clinical Studies In Adult Horsescontrasting

confidence: 52%

Section: Clinical Studies In Adult Horsesmentioning

confidence: 76%

Section: Clinical Studies In Adult Horsesmentioning

confidence: 99%

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The use of Probiotics in Horses with Gastrointestinal Disease

Gotić¹,

Grden²,

Babić³

et al. 2017

American Journal of Animal and Veterinary Sciences

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“…Probiotics have been shown to be unable to colonize the gastrointestinal tract of horses and it is therefore unlikely that they can act beyond their period of administration 7, 10. The 1 week of treatment course chosen in previous studies therefore might not be sufficient to see an effect 3, 5, 9.…”

Section: Discussionmentioning

confidence: 99%

“…Probiotics exert their beneficial effect through several pathways, including production of antimicrobial compounds targeting intestinal pathogens and their toxins, as well as general immune stimulation and colonization resistance 6. Few studies in horses have been performed to date to evaluate the efficacy of probiotics in prevention or treatment of enteric disease 4, 7, 8. The 2 studies on probiotic use to prevent neonatal foal diarrhea failed to show a lack of significant effect of probiotic treatment 3, 9.…”

mentioning

confidence: 99%

Effect of a Probiotic on Prevention of Diarrhea and Clostridium difficile and Clostridium perfringens Shedding in Foals

Schoster

Staempfli

Abrahams

et al. 2015

Veterinary Internal Medicne

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BackgroundUp to 60% of foals develop diarrhea within 6 months after birth. Preventive measures are limited but potentially probiotics could be used.ObjectiveTo evaluate the effect of a newly designed probiotic on the incidence of foal diarrhea in a randomized field trial.AnimalsSeventy‐two healthy neonatal foals.MethodsRandomized, placebo‐controlled field trial. Foals were administered a placebo or probiotic for 3 weeks and monitored for an additional week. A total of 3 fecal samples were taken from each foal at biweekly intervals. Statistical modeling was applied for comparison of incidence and duration of diarrhea and fecal shedding of Clostridium perfringens and Clostridium difficile between treatment and age groups.ResultsThe overall incidence of diarrhea was 41 of 72 (59%) and did not differ (P = 0.37) between treatment groups. Foals treated with probiotics were more likely to develop diarrhea requiring veterinary intervention (P = 0.007). Age had a significant effect on incidence of diarrhea (P < 0.001); foals 8–15 days old having the highest probability of developing diarrhea. Duration of diarrhea and soft feces were not significantly different between groups. The prevalence of C. perfringens shedding was 55% with no difference between treatment groups (P = 0.23). The prevalence of C. difficile shedding was 11%.Conclusion and Clinical ImportanceThere was no benefit of administering a 3‐week course of probiotics, but potential adverse effects were noted. Whether the probiotics lacked a clinical effect, or the choice of strains or dose was inadequate, is unknown. Clostridial shedding was not influenced by probiotics despite in vitro activity of probiotics.

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Postoperative Complications

Hassel¹

2012

Practical Guide to Equine Colic

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Efficacy of Saccharomyces boulardii for treatment of horses with acute enterocolitis

Abstract: Administration of S. boulardii may help decrease the severity and duration of clinical signs in horses with acute enterocolitis.

Cited by 69 publications

References 22 publications

The use of Probiotics in Horses with Gastrointestinal Disease

The use of Probiotics in Horses with Gastrointestinal Disease

Effect of a Probiotic on Prevention of Diarrhea and Clostridium difficile and Clostridium perfringens Shedding in Foals

Postoperative Complications

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