Efficacy of RUTI® immunotherapy against active tuberculosis in a mouse model challenges the Koch phenomenon
Pablo Soldevilla,
Anna Buisan,
Jorge Diaz
et al.
Abstract:ObjectivesThe objective of this study was to evaluate the safety and efficacy of the therapeutic vaccine RUTI® with or without the standard of care (SOC) chemotherapy for TB in an experimental murine model.MethodsWe assessed the efficacy of RUTI®, a vaccine based on pasteurized and freeze-dried cell-wall fragments from Mycobacterium tuberculosis (Mtb), the SOC for sensitive TB (isoniazid, rifampicin, ethambutol, and pyrazinamide) in the murine active TB model in C3HeB/FeJ strain (Kramnik model). We evaluated t… Show more
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