Efficacy of RESOLVE DWI in the staging of Graves ’ophthalmopathy compared with conventional MRI

Abstract

Purpose. To determine the efficacy of RESOLVE DWI in the staging of GO compared with conventional magnetic resonance imaging (MRI). Methods. A total of 58 consecutive GO patients were enrolled and divided into two groups according to the patients’ clinical activity score (CAS). Signal intensity ratio (SIR) of extraocular muscle (EOM) on coronal T2-weighted imaging (T2WI) with fat suppression and apparent diffusion coefficient (ADC) value of EOM for ADC map was measured and analyzed. Results. Both SIR and ADC values in the active GO were significantly higher than those of inactive GO(P＜0.001). SIR and ADC values were positively correlated with CAS (r＝ 0.58, 0.55; P<0.001).When SIR of 2.2 and ADC value of 1467.64 × 10－6 mm2/s of the EOM were used as threshold values for staging GO, respectively, the best results were obtained with a sensitivity of 64%,59%, and specificity of 88%,86%. There was no significant difference in area under the curve between SIR and ADC. Conclusion. RESOLVE DWI has the potential to be a valuable MRI tool in the staging of GO in addition to conventional MRI.