Efficacy of repetitive transcranial magnetic stimulation in alcohol dependence: a sham‐controlled study

Mishra, Biswa Ranjan; Nizamie, S. Haque; Das, Basudeb; Praharaj, Samir Kumar

doi:10.1111/j.1360-0443.2009.02777.x

Cited by 205 publications

(159 citation statements)

References 23 publications

(33 reference statements)

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“…The level of alcohol craving was assessed with the Alcohol Craving Questionnaire (ACQ-NOW) before and after rTMS treatment, and 1 month following. The results of the study demonstrated a signifi cant reduction in the level of craving scores in patients who received active compared to sham rTMS (Mishra et al, 2010). Although this study was single blind and by extension susceptible to rater bias, it provides support for the ability of high frequency rTMS over the right DLPFC to reduce alcohol cravings.…”

Section: Treatment Of Alcoholism With Rtmsmentioning

confidence: 74%

“…In spite of the availability of several anti-craving medications (e.g. acamprosate and naltrexone) the effi cacy of these drugs is limited for alcohol dependence (Mishra et al, 2010). Similar to the lines of evidences for the potential of rTMS to treat nicotine dependence, such as its action on the neurotransmitter systems including dopamine and GABA, rTMS has also been examined for its ability to treat alcohol dependence.…”

Section: Pathophysiology Of Alcohol Addictionmentioning

confidence: 99%

“…First, in a single blind prospective sham-controlled study, Mishra et al (2010) examined the ability of high frequency rTMS to treat patients with alcohol dependence, determined by the ICD-10, with Clinical Institute of Withdrawal (CIWA-Ar) scores Յ 10. In their study, 45 patients were randomized to receive either active or sham stimulation in a 2:1 ratio whereby 30 patients received active stimulation and 15 patients received sham applied at 10 Hz rTMS (110% resting motor threshold in 20 trains, 50 pulses per train, 30 s inter-train interval) to the right DLPFC for 10 sessions.…”

Section: Treatment Of Alcoholism With Rtmsmentioning

confidence: 99%

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Repetitive transcranial magnetic stimulation and drug addiction

Barr

Farzan

Wing

et al. 2011

International Review of Psychiatry

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Repetitive transcranial magnetic stimulation (rTMS) is a non-invasive brain stimulation technique that is now being tested for its ability to treat addiction. This review discusses current research approaches and results of studies which measured the therapeutic use of rTMS to treat tobacco, alcohol and illicit drug addiction. The research in this area is limited and therefore all studies evaluating the therapeutic use of rTMS in tobacco, alcohol or illicit drug addiction were retained including case studies through NCBI PubMed (http://www.ncbi.nlm.nih.gov) and manual searches. A total of eight studies were identifi ed that examined the ability of rTMS to treat tobacco, alcohol and cocaine addiction. The results of this review indicate that rTMS is effective in reducing the level of cravings for smoking, alcohol, and cocaine when applied at high frequencies to the dorsolateral prefrontal cortex (DLPFC). Furthermore, these studies suggest that repeated sessions of high frequency rTMS over the DLPFC may be most effective in reducing the level of smoking and alcohol consumption. Although work in this area is limited, this review indicates that rTMS is a promising modality for treating drug addiction.

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Section: Treatment Of Alcoholism With Rtmsmentioning

confidence: 74%

Section: Pathophysiology Of Alcohol Addictionmentioning

confidence: 99%

Section: Treatment Of Alcoholism With Rtmsmentioning

confidence: 99%

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Repetitive transcranial magnetic stimulation and drug addiction

Barr

Farzan

Wing

et al. 2011

International Review of Psychiatry

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“…Therefore, whether the increase of PAS-induced LTD-like plasticity in motor cortex by low-dose ethanol provides a surrogate marker for the addictive potential of ethanol in given individuals would require further deliberate testing. On the other hand, it is of interest to note that several recent therapeutic trials applied high-frequency repetitive TMS to the dorsolateral prefrontal cortex of alcohol addicts and observed a decrease in spontaneous alcohol craving (Gorelick et al, 2014;Höppner et al, 2011;Mishra et al, 2010). High-frequency repetitive TMS typically leads to LTPlike plasticity (for review, ) so that these therapeutic effects may be explained by counteracting LTDdependent mechanisms of addiction, in addition to other potential mechanisms, such as modulation of dopaminergic neurotransmission in addiction-related subcortical target areas of the dorsolateral prefrontal cortex (Feil and Zangen, 2010;Naim-Feil and Zangen, 2013).…”

Section: Behavioral Significance Of the Present Findingsmentioning

confidence: 99%

Low Doses of Ethanol Enhance LTD-like Plasticity in Human Motor Cortex

Fuhl

Müller‐Dahlhaus

Lücke

et al. 2015

Neuropsychopharmacol

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Humans liberally use ethanol for its facilitating effects on social interactions but its effects on central nervous system function remain underexplored. We have recently described that very low doses of ethanol abolish long-term potentiation (LTP)-like plasticity in human cortex, most likely through enhancement of tonic inhibition [Lücke et al, 2014, Neuropsychopharmacology 39:1508. Here, we studied the effects of low-dose ethanol on long-term depression (LTD)-like plasticity. LTD-like plasticity was induced in human motor cortex by paired associative transcranial magnetic stimulation (PAS LTD ), and measured as decreases of motor evoked potential input-output curve (IO-curve). In addition, sedation was measured by decreases in saccade peak velocity (SPV). Ethanol in two low doses (EtOH o10mM , EtOH o20mM ) was compared to single oral doses of alprazolam (APZ, 1mg) a classical benzodiazepine, and zolpidem (ZLP, 10 mg), a non-benzodiazepine hypnotic, in a double-blinded randomized placebo-controlled crossover design in ten healthy human subjects. EtOH o10mM and EtOH o20mM but not APZ or ZLP enhanced the PAS LTD -induced LTD-like plasticity, while APZ and ZLP but not EtOH o10mM or EtOH o20mM decreased SPV. Non-sedating low doses of ethanol, easily reached during social drinking, enhance LTD-like plasticity in human cortex. This effect is most likely explained by the activation of extrasynaptic α4-subunit containing gammaaminobutyric type A receptors by low-dose EtOH, resulting in increased tonic inhibition. Findings may stimulate cellular research on the role of tonic inhibition in regulating excitability and plasticity of cortical neuronal networks.

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“…Por otro lado, hay algunos estudios controlados publicados en los que la EMT se muestra eficaz ayudando a los pacientes a disminuir el consumo de tabaco (Amiaz, Levy, Vainiger, Grunhaus y Zangen, 2009;Eichhammer et al, 2003). Además, se ha demostrado capaz de disminuir el craving en adictos a cocaína y al alcohol (Barr et al, 2008; Camprodon, Martínez-Raga, Alonso-Alonso, Shihy y Pascual- Leone, 2007;De Ridder et al, 2011;Mishra, Nizamie, Das y Praharaj, 2010). Por otro lado, es significativo que se haya publicado también que la EMT puede disminuir el craving a la comida en pacientes con trastornos de la conducta alimentaria (Uher et al, 2005;Van den Eynde et al, 2010).…”

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