Efficacy of remineralizing agents to occlude dentinal tubules in primary teeth subjected to dentin hypersensitivity in vitro: SEM study

Mathew, Mebin George; Soni, Ashu Jagdish; Khan, Muzammil; Kauser, Afreen; Charan, Vunnam Sri Sai; Akula, Sunil Kumar

doi:10.4103/jfmpc.jfmpc_853_19

Cited by 17 publications

(14 citation statements)

References 24 publications

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“…►Fig. 5 shows the SEM images of etched dentin. As seen all dentinal tubules were patent with an average diameter of 2.8 ± 0.9 µm.…”

Section: Scanning Electron Microscopymentioning

confidence: 99%

“… 2 3 4 Many commercially available toothpastes have been proposed for such purpose. They depend on the incorporation of active ingredients with remineralizing potential 5 such as nanohydroxyapatite (e.g., Biorepair Fast Sensitive Repair), 6 casein phosphopeptide-amorphous calcium phosphate (e.g., GC tooth mousse), 7 or fluoride (e.g., Sensodyne Repair & Protect). 8 However, there is no gold standard toothpaste that could afford complete and persistent cure.…”

Section: Introductionmentioning

confidence: 99%

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An Eggshell-Based Toothpaste as a Cost-Effective Treatment of Dentin Hypersensitivity

Neel

Bakhsh

2021

Eur J Dent

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Objectives This study aimed to test the efficacy of two experimentally produced eggshell-based toothpastes on dentinal tubules occlusion. Materials and Methods Two experimental eggshell toothpastes, based on natural ingredients, with or without titanium dioxide nanoparticles (TNPs) were produced and coded “TNPs eggshell toothpaste [TNPsESTP]” or “eggshell toothpaste [ESTP],” respectively. Mid-coronal dentin discs, from 28 human extracted molar teeth, etched with 37% phosphoric acid for 60 seconds to simulate the hypersensitive dentin, were randomly divided into four groups—G1: no treatment (negative control), G2: ESTP treated, G3: TNPsESTP treated, and G4: Biorepair treated (positive control). All treated discs were brushed for 2 weeks and 1 month using a toothbrush simulator at 40 mm/s. Dentinal tubules occlusion was studied using a cross-polarization optical coherence tomography (CP-OCT) and scanning electron microscopy (SEM). Statistical Analysis Unpaired t-test was conducted using GraphPad software (San Diego, California, United States). Continuous variables were expressed as means ± standard deviation and p < 0.05 was considered statistically significant. Results From CP-OCT, a marked increase in surface reflectivity of dentin was observed after brushing with tested toothpastes. ESTP and NPsESTP showed higher or comparable grayscale values than Biorepair indicating increase in surface density of dentin. From SEM, at 2 weeks, ESTP showed comparable number of completely occluded dentinal tubules to Biorepair. TNPsESTP showed significantly lower numbers of CODT than Biorepair. At 1 month, the number of CODT was difficult to count for all treated groups. Both ESTP and TNPsESTP showed significantly higher numbers of partially occluded dentinal tubules than Biorepair. Conclusion ESTP or TNPsESTP could offer a cost-effective substitute for the treatment of dentin hypersensitivity.

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“…►Fig. 5 shows the SEM images of etched dentin. As seen all dentinal tubules were patent with an average diameter of 2.8 ± 0.9 µm.…”

Section: Scanning Electron Microscopymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

An Eggshell-Based Toothpaste as a Cost-Effective Treatment of Dentin Hypersensitivity

Neel

Bakhsh

2021

Eur J Dent

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“…Brannstrom's hydrodynamic theory proved that the pain sensation is caused by pulp nerves extremities stimulation through the occurrence of cervical enamel lesions, due to the indirect effect of dentinal fluid movement inside the tubules, after the exposure of dentinal tubules to the oral environmental (1) . Dentin permeability is generally measured during evaluations of the sealing ability to desensitize materials (2) .…”

Section: Introductionmentioning

confidence: 99%

Effect of Diode Laser and Iontophoresis with Aqueous Extract of Nigella sativa and Fluoride-Based-Agent on Dentin Permeability

2022

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“…The symptoms of hypersensitivity are improved by low-power diode lasers, sodium fluoride varnish, and occluding dentinal tubule agents [ 27 , 28 ]. Hydroxyapatite is a good hypersensitivity inhibitor material because it greatly occludes the dentinal tubule in vitro [ 29 ]. However, no agents have been reported to improve both color tone and hypersensitivity; therefore, the development of new agents is a pressing issue.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of a Hypersensitivity Inhibitor Containing a Novel Monomer That Induces Remineralization—A Case Series in Pediatric Patients

et al. 2021

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Background: Recently, tooth deformities have been frequently encountered by pediatric dentists. Severe enamel hypomineralization sometimes induces pain such as hyperesthesia, but composite resin restoration is difficult because it often detaches without any cavity preparation. Resin-based hypersensitivity inhibitors for tooth physically seal the dentinal tubules. It was reported that hypersensitivity inhibitor containing novel adhesive monomers forms apatite and induces remineralization in vitro. Therefore, these case series assessed the clinical effects of remineralization and the suppression of hypersensitivity by Bio Coat Ca (Sun Medical, Shiga, Japan). Methods: After mechanical tooth cleaning was performed, the hypersensitivity inhibitors were applied and cured by light exposure. Changes in hypersensitivity were determined by visual analog scale (VAS). The improvement of hypomineralization was evaluated by the change in color tone based on the digital images of intraoral photographs. Results: After repeated monthly treatments, these cases showed decreased hypersensitivity after the fourth application, while the opaque white and brownish color improved on the seventh application. Conclusion: This novel hypersensitivity inhibitor with calcium salt of 4-methacryloxyethyl trimellitic acid (C-MET) and 10-methacryloyloxydecyl dihydrogen calcium phosphate (MDCP) not only suppressed hypersensitivity but also improved cloudiness and brown spots in recently erupted permanent teeth in presented cases.

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Efficacy of remineralizing agents to occlude dentinal tubules in primary teeth subjected to dentin hypersensitivity in vitro: SEM study

Cited by 17 publications

References 24 publications

An Eggshell-Based Toothpaste as a Cost-Effective Treatment of Dentin Hypersensitivity

An Eggshell-Based Toothpaste as a Cost-Effective Treatment of Dentin Hypersensitivity

Effect of Diode Laser and Iontophoresis with Aqueous Extract of Nigella sativa and Fluoride-Based-Agent on Dentin Permeability

Evaluation of a Hypersensitivity Inhibitor Containing a Novel Monomer That Induces Remineralization—A Case Series in Pediatric Patients

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