Efficacy of pyrantel pamoate and ivermectin paste formulations against naturally acquired Oxyuris equi infections in horses

Reinemeyer, Craig R.; Prado, Julio César Acosta; Nichols, Eric C.; Marchiondo, Alan A.

doi:10.1016/j.vetpar.2010.02.042

Cited by 20 publications

(8 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…These cases occurred despite histories of regular treatment with a ML and were suggestive of resistance. There have been similar concerns expressed overseas, but when following up one such instance, Reinemeyer et al (2010) reported 96% and >99% efficacy of ivermectin against adult and L4 O. equi, respectively. This was based on actual worm counts of naturally infected horses and efficacy was calculated using geometric means.…”

Section: Anthelmintic Resistance: What Has Been Reported In New Zealamentioning

confidence: 87%

Anthelmintic resistance in equine helminth parasites – a growing issue for horse owners and veterinarians in New Zealand?

Scott

Bishop²,

Pomroy

2015

New Zealand Veterinary Journal

View full text Add to dashboard Cite

There is growing concern that given the high frequency with which anthelmintics are being administered to many horses, anthelmintic resistance amongst equine helminth populations will be an increasing problem, rendering many of the currently available products unusable with little prospect of new products becoming available, at least in the near future. Worldwide, much reliance has been placed on the macrocyclic lactone (ML) group of anthelmintics, but resistance has been reported to these products as well as to the two other major anthelmintic classes used in this species, the benzimidazoles (BZ) and the tetrahydropyrimidines (e.g. pyrantel). In New Zealand, resistance has been reported to the ML and BZ groups, but not yet to pyrantel. As an alternative to interval-based anthelmintic regimens, the highly overdispersed nature of parasite populations in horses can be utilised to decide whether treatment is required, based on whether or not animals exceed a predetermined level of shedding of parasite eggs. If well managed, such a targeted and selective approach can be utilised to eliminate the majority of egg output whilst still providing a refuge for susceptible parasites to persist. Such a system would require that an adequate standard of monitoring be in place and cognisance needs to be taken of parasites or their lifecycle stages that cannot be diagnosed by routine methods. At the same time, using anthelmintics with high levels of efficacy, avoiding practices such as under-dosing, as well as utilising non-chemical means of parasite control when possible, e.g. regular removal of faeces from pasture, should all be considered. Combinations of anthelmintics, specifically of anthelmintics that target the same or a similar spectrum of parasite species, should play an important role in parasite control in horses. As well as providing arguably the highest levels of efficacy, combinations may also slow the rate at which anthelmintic resistance develops.

show abstract

Section: Anthelmintic Resistance: What Has Been Reported In New Zealamentioning

confidence: 87%

Anthelmintic resistance in equine helminth parasites – a growing issue for horse owners and veterinarians in New Zealand?

Scott

Bishop²,

Pomroy

2015

New Zealand Veterinary Journal

View full text Add to dashboard Cite

show abstract

“…It was reported that the recommended dose level of PYR (13.2 mg/kg, bodyweight) pamoate paste formulation was effective (95-98%) against infections of Anoplocephala perfoliata (FDA, 2005). Moreover, a recent investigation by Reinemeyer et al, 2010 indicated that PYR pamoate paste formulation was highly effective against adult (91.2%) and fourth-stage Oxyrus equi larvae (>99%).…”

Section: Introductionmentioning

confidence: 99%

Plasma pharmacokinetics, faecal excretion and efficacy of pyrantel pamoate paste and granule formulations following per os administration in donkeys naturally infected with intestinal strongylidae

Gökbulut

Akşit

Smaldone

et al. 2014

Veterinary Parasitology

View full text Add to dashboard Cite

“…Contudo, estudos recentes como o de Wolf et al (2013) e Sallè et al (2016) demonstraram que O. equi têm apresentado resistência às avermectinas. Neste caso, os princípios-ativos mais eficazes são o pamoato de pirantel (FELIPPELLI, 2015) e o triclorfon (REINEMEYER et al, 2010), que têm ação adulticida e larvicida. Ainda muito utilizado, de amplo espectro e com bons resultados, a ivermectina é uma opção (FELIPPELLI, 2015).…”

Section: Resultsunclassified

Prevalência de oxiuríase em equinos do Centro Hípico do 3º Regimento de Cavalaria de Guarda do Exército Brasileiro

Mello¹,

Marques²,

Murari³

et al. 2020

Rev Agr Acad

View full text Add to dashboard Cite

show abstract

Efficacy of pyrantel pamoate and ivermectin paste formulations against naturally acquired Oxyuris equi infections in horses

Cited by 20 publications

References 11 publications

Anthelmintic resistance in equine helminth parasites – a growing issue for horse owners and veterinarians in New Zealand?

Anthelmintic resistance in equine helminth parasites – a growing issue for horse owners and veterinarians in New Zealand?

Plasma pharmacokinetics, faecal excretion and efficacy of pyrantel pamoate paste and granule formulations following per os administration in donkeys naturally infected with intestinal strongylidae

Prevalência de oxiuríase em equinos do Centro Hípico do 3º Regimento de Cavalaria de Guarda do Exército Brasileiro

Contact Info

Product

Resources

About