Objectives: To develop a non-invasive measurement of continuous monitoring of hemoglobin using IoT-enabled pulse oximetry. Currently in India, most women, senior citizens, and rural area people are suffering from anemia. In many cases, people unable to visit hospitals and laboratories for hemoglobin testing. To help the above people our proposed system will measure hemoglobin concentration without visiting the hospital at an affordable price. Methods: We developed real-time continuous monitoring of Hb concentration and oxygen saturation (SpO 2) using pulse oximetry. In this study, 47 healthy volunteers were participated and measure the above-mentioned parameters under resting conditions. Findings: The obtained results were in unison with laboratory measurements with the variation of 0.12g/dL to 1.0g/dL. Novelty/Applications: Experimental results showed the approach of continuous monitoring of hemoglobin and SpO 2 using an IoT-enabled noninvasive method can be useful in healthcare management.