Efficacy of PRP in the Reconstruction of Mandibular Segmental Defects Using Iliac Bone Grafts

Abstract

This retrospective study was conducted to evaluate the role of platelet-rich plasma (PRP) in the reconstruction of segmental mandibular defects using iliac bone grafts. Thirteen patients underwent reconstruction of post-resection segmental defects of the mandible using titanium reconstruction plates, cortico cancellous iliac bone graft. The patients were randomly separated into two groups. One group of the patients received a PRP graft in addition to the iliac bone graft. Post-operative dimensions of the graft were measured and compared to assess the efficacy of PRP in reconstruction of segmental defects. The post-operative follow-up radiographs confirmed consolidation of the graft in all cases and the segmental defect was obliterated. Thereby mandibular continuity was successfully achieved in all cases. Two patients in the non-PRP group developed an infection and were administered additional antibiotics. The infection was contained and the grafts survived. The use of PRP along with autogenous bone graft may be advantageous since it appeared to enhance the quantity of bone formed. Further long-term follow-up and studies are required to effectively establish the efficacy of PRP and autogenous free bone grafts in the reconstruction of bony defects.

The Bone Regeneration Using Bone Marrow Stromal Cells with Moderate Concentration Platelet-Rich Plasma in Femoral Segmental Defect of Rats

“…PRP has been reported to stimulate bone regeneration [ 5 - 8 ]. Recently, second-generation platelet concentrates such as platelet-rich fibrin and concentrated growth factor have been noted to slowly release platelet growth factor and enable healing of bony defect in vivo [ 19 - 21 ].…”

Immediate iliac bone graft reconstruction of post ablative defect of benign mandibular pathology - a systematic review

“…[ [33][34][35][36][37] On the other hand, other studies in the review got comparable or even better result despite not utilizing PRP. [23,26] Therefore it may be difficult to ascribe the outcome to any beneficial effect of PRP as claimed by the authors.…”

The healing effect of platelet-rich plasma on xenograft in peri-implant bone defects in rabbits

“…Some authors such as Marx et al, Magesh et al [ 18 ], and Aimetti et al [ 19 ] evaluated the effect of PRP on bone regeneration in human. In their studies, the bone defects were treated with an autogenous bone graft alone or in combination with PRP, and they all demonstrated that the use of PRP along with an autogenous bone graft were advantageous since it enhanced the quantity of newly formed bone.…”