Efficacy of Propranolol in Hepatic Infantile Hemangiomas with Diffuse Neonatal Hemangiomatosis

Mazereeuw‐Hautier, J.; Hoeger, Peter H.; Benlahrech, Sarah; Ammour, Amir; Broué, Pierre; Vial, J.; Ohanessian, Gérard; Léauté‐Labrèze, Christine; M, Labenne; Vabres, P.; Rößler, Jochen; Bodemer, Christine

doi:10.1016/j.jpeds.2010.04.003

Cited by 139 publications

(79 citation statements)

References 11 publications

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“…Moreover, this treatment was well tolerated and without adverse effects. Mazereeuw-Hautier et al [17] have confirmed our results, reporting the rapid and dramatic efficacy of propranolol in 8 infants with infantile hepatic hemangiomas. Altogether, these data suggest that propranolol should be considered an important therapeutic option in the treatment of infantile hepatic hemangiomas, particularly in light of the side effects produced by steroids or vincristine in young children.…”

Section: Discussionsupporting

confidence: 89%

Efficacy of Propranolol Treatment in Thyroid Dysfunction Associated with Severe Infantile Hepatic Hemangioma

et al. 2012

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Infantile hepatic hemangioma can be associated to consumptive hypothyroidism due to overexpression of type 3 deiodinase in the endothelium of vascular tumor, which catalyzes the conversion of T4 to reverse T3 (rT3) and of T3 to T2, both of which are biologically inactive. Here, we report an infant with a massive biopsy-proven infantile hepatic hemangioma who developed thyroid dysfunction without a typical biochemical profile consistent with severe consumptive hypothyroidism, despite the large tumor burden. Our patient was treated with propranolol that rapidly resolved both hepatic hemangioma and thyroid dysfunction. We propose propranolol as a first-line therapy of thyroid dysfunction associated with infantile hepatic hemangioma, in order to avoid interference with neurological development caused by hypothyroidism in the first months of life.

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Section: Discussionsupporting

confidence: 89%

Efficacy of Propranolol Treatment in Thyroid Dysfunction Associated with Severe Infantile Hepatic Hemangioma

et al. 2012

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“…Effective IH treatment will result in a gradual reduction in the requirement for thyroid replacement and eventual return to the euthyroid state. 366,367 High-flow shunts are uncommon in diffuse lesions. There is no role for embolization in the absence of macrovascular shunts and a highoutput state.…”

Section: Highlights Of This Sectionmentioning

confidence: 99%

Diagnosis and Management of Infantile Hemangioma

Darrow¹,

Mancini²,

Nopper³

et al. 2015

Pediatrics

205

290

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Infantile hemangiomas (IHs) are the most common tumors of childhood. Unlike other tumors, they have the unique ability to involute after proliferation, often leading primary care providers to assume they will resolve without intervention or consequence. Unfortunately, a subset of IHs rapidly develop complications, resulting in pain, functional impairment, or permanent disfigurement. As a result, the primary clinician has the task of determining which lesions require early consultation with a specialist. Although several recent reviews have been published, this clinical report is the first based on input from individuals representing the many specialties involved in the treatment of IH. Its purpose is to update the pediatric community regarding recent discoveries in IH pathogenesis, treatment, and clinical associations and to provide a basis for clinical decision-making in the management of IH.

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“…Since then, propranolol treatment for IH has become popular worldwide and positive results with its use are reported by many groups (Cheng et al 2010;Mazereeuw-Hautier et al 2010;Rosbe et al 2010). Propranolol is a noncardioselective b-adrenergic receptor blocker used traditionally for other indications such as hypertension, angina pectoris, myocardial infarction, migraines, anxiety disorders, and tremor.…”

Section: Propranololmentioning

confidence: 99%

Infantile Hemangioma--Mechanism(s) of Drug Action on a Vascular Tumor

Greenberger¹,

Bischoff²

2011

Cold Spring Harbor Perspectives in Medicine

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Infantile hemangioma (IH), a benign vascular tumor, is the most common tumor of infancy, with an incidence of 5% -10% at the end of the first year. The tumor displays a distinctive life cycle consisting of a proliferating phase, occurring in the first months of life, followed by an involuting phase. Thus, IH represents a unique model of postnatal vasculogenesis, angiogenesis, and vessel regression. Traditionally, corticosteroids were the drug of choice when treatment of IH was indicated. In recent years, beta-blockers, most specifically propranolol, have serendipitously been shown to be an effective pharmacological treatment. This article will focus on the mechanism of action of these two drugs, the old and the new treatments, in slowing the growth and accelerating involution of IH.

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Efficacy of Propranolol in Hepatic Infantile Hemangiomas with Diffuse Neonatal Hemangiomatosis

Cited by 139 publications

References 11 publications

Efficacy of Propranolol Treatment in Thyroid Dysfunction Associated with Severe Infantile Hepatic Hemangioma

Efficacy of Propranolol Treatment in Thyroid Dysfunction Associated with Severe Infantile Hepatic Hemangioma

Diagnosis and Management of Infantile Hemangioma

Infantile Hemangioma--Mechanism(s) of Drug Action on a Vascular Tumor

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