Efficacy of prophylactic platelet rich plasma (PRP) following open saphenous vein harvesting in cardiac surgery

Jiritano, Federica; Serra, Raffaele; Nenna, Antonio; Curcillo, Antonio; Villella, Francesco; Nappi, Francesco; Chello, Camilla; Chello, Massimo; Mastroroberto, Pasquale; Serraino, Giuseppe Filiberto

doi:10.31083/j.fbe1402012

Cited by 6 publications

(8 citation statements)

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“…In the research that was utilised for the meta-analysis, 8961 CS persons were in the utilised researchers' starting point, 3663 of them were utilising PRP, and 5298 were control. [12][13][14][15][16][17][18][19][20][21][22] PRP had significantly lower SWI, deep SWI, and superficial SWI, compared to control in CS persons. However, when interacting with its values, caution must be taken since a low sample size of some of the nominated researchers was found for the comparisons in the meta-analysis (5 out of 11 <200 persons).…”

Section: Discussionmentioning

confidence: 81%

“…Eleven papers, published between 2005 and 2022, from a total of 1098 linked research that met the inclusion criteria were chosen for the research. [12][13][14][15][16][17][18][19][20][21][22] The consequences of these investigations are accessible in Table 2. 8961 CS persons were in the utilised researchers' starting point, 3663 of them were utilising PRP, and 5298 were control.…”

Section: Resultsmentioning

confidence: 99%

“…Eleven papers, published between 2005 and 2022, from a total of 1098 linked research that met the inclusion criteria were chosen for the research 12‐22 . The consequences of these investigations are accessible in Table 2.…”

Section: Resultsmentioning

confidence: 99%

“…In the research that was utilised for the meta‐analysis, 8961 CS persons were in the utilised researchers' starting point, 3663 of them were utilising PRP, and 5298 were control 12‐22 . PRP had significantly lower SWI, deep SWI, and superficial SWI, compared to control in CS persons.…”

Section: Discussionmentioning

confidence: 99%

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Platelet‐rich plasma influence on the sternal wounds healing: A meta‐analysis

Zhu

Gao

et al. 2023

International Wound Journal

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A meta‐analysis research was executed to appraise the effect of platelet‐rich plasma (PRP) on sternal wound healing (SWH). Inclusive literature research till April 2023 was done and 1098 interconnected researches were revised. The 11 picked researches, enclosed 8961 cardiac surgery (CS) persons were in the utilised researchers' starting point, 3663 of them were utilising PRP, and 5298 were control. Odds ratio (OR) and 95% confidence intervals (CIs) were utilised to appraise the effect of PRP on the SWH by the dichotomous approach and a fixed or random model. PRP had significantly lower sternal wound infection (SWI) (OR, 0.11; 95% CI, 0.03–0.34, p < 0.001), deep SWI (OR, 0.29; 95% CI, 0.16–0.51, p < 0.001), and superficial SWI (OR, 0.20; 95% CI, 0.13–0.33, p < 0.001), compared to control in CS persons. PRP had significantly lower SWI, deep SWI, and superficial SWI, compared to control in CS persons. However, caution must be taken when interacting with its values since there was a low sample size of some of the nominated research found for the comparisons in the meta‐analysis.

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Section: Discussionmentioning

confidence: 81%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Platelet‐rich plasma influence on the sternal wounds healing: A meta‐analysis

Zhu

Gao

et al. 2023

International Wound Journal

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“…The first generation of platelet concentrates is termed platelet-rich plasma (PRP) which includes the addition of an anticoagulant to the blood sample which prevents clotting during the centrifugation cycle [ 34 ]. PRP is the most widely studied platelet concentrate in regenerative medicine with many investigations demonstrating its benefit in cardiac surgery [ 35 ], osteoarthritis [ 36 ], osteoporosis [ 37 ], dermal rejuvenation [ 34 ], and dentistry [ 38 , 39 ]. It possesses antimicrobial [ 40 ], anti-inflammatory [ 41 ], and regenerative properties [ 42 ].…”

Section: Pdbs Used In Clinical Therapiesmentioning

confidence: 99%

The Potential Therapeutic Effects of Platelet-Derived Biomaterials on Osteoporosis: A Comprehensive Review of Current Evidence

Amiri,

Farshidfar,

Miron

et al. 2023

International Journal of Biomaterials

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Osteoporosis is a chronic multifactorial condition that affects the skeletal system, leading to the deterioration of bone microstructure and an increased risk of bone fracture. Platelet-derived biomaterials (PDBs), so-called platelet concentrates, such as platelet-rich plasma (PRP) and platelet-rich fibrin (PRF), have shown potential for improving bone healing by addressing microstructural impairment. While the administration of platelet concentrates has yielded positive results in bone regeneration, the optimal method for its administration in the clinical setting is still debatable. This comprehensive review aims to explore the systemic and local use of PRP/PRF for treating various bone defects and acute fractures in patients with osteoporosis. Furthermore, combining PRP/PRF with stem cells or osteoinductive and osteoconductive biomaterials has shown promise in restoring bone microstructural properties, treating bony defects, and improving implant osseointegration in osteoporotic animal models. Here, reviewing the results of in vitro and in vivo studies, this comprehensive evaluation provides a detailed mechanism for how platelet concentrates may support the healing process of osteoporotic bone fractures.

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