Efficacy of probiotics in non‐alcoholic fatty liver disease in adult and children: A meta‐analysis of randomized controlled trials

Gao, Xiaolin; Zhu, Yu; Yang, Wen; Liu, Guanjian; Wan, Chaomin

doi:10.1111/hepr.12671

Cited by 86 publications

(65 citation statements)

References 24 publications

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“…Effects on BMI and other anthropometric parameters were not evident in adult patients, whereas it was more evident in children (26). Similar results were found in our study, except in improvement in insulin resistance.…”

Section: Discussionsupporting

confidence: 91%

“…In contrast, Ipar et al (28) found significant improvement only in TC and LDL levels and not in TG levels after synbiotic supplementation, as in our study. Effects of probiotics or synbiotics on TG levels have some controversies; Gao et al (26) revealed that lipid-lowering effect of probiotics or synbiotics may vary in different countries/ethnicities. Additionally, types of the strain in probiotics, types of the prebiotics used for the study, and the duration of the treatment may affect lipidlowering property (29,30).…”

Section: Discussionmentioning

confidence: 99%

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Effects of long-term synbiotic supplementation in addition to lifestyle changes in children with obesity-related non-alcoholic fatty liver disease

Çakır¹,

İşbilen²,

Eyüpoglu³

et al. 2017

Turk J Gastroenterol

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Background/Aims:We aimed to analyze the efficiency of a novel treatment approach, long-term synbiotic supplementation, in addition to lifestyle changes in children with non-alcoholic fatty liver disease (NAFLD). Materials and Methods: The study included children with NAFLD (n=28) and a healthy control group (n=30). Children with NAFLD were given 1 capsule/day of synbiotics. Anthropometric parameters; biochemical analysis, including ethanol, tumor necrosis factor-α (TNF-α), total oxidant status (TOS) and anti-oxidant status (TAS), zonulin, and fecal calprotectin; and ultrasonographic examination were performed at baseline and 4 months later. Results: The grade of fatty liver was decreased (≥1 grade) in 19 of the 28 patients (67.8%) after synbiotic supplementation. Total cholesterol, low-density lipoprotein (LDL) levels, TNF-α, C-reactive protein (CRP), and ethanol were significantly decreased, and TAS levels were significantly increased at the end of treatment (p<0.05 for all). We found that the median decrease in CRP (-0.16 vs. -0.03 mg/dL, p=0.003) and LDL levels (-17 vs. -3 mg/dL, p=0.019) were higher in patients who responded to the supplementation.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Effects of long-term synbiotic supplementation in addition to lifestyle changes in children with obesity-related non-alcoholic fatty liver disease

Çakır¹,

İşbilen²,

Eyüpoglu³

et al. 2017

Turk J Gastroenterol

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“…In another study, probiotic supplementation in pediatric obesity-related liver disease for 8 weeks decreased ALT serum level (27). Also, a meta analysis study in 2016 reviewed efficacy of probiotics in nonalcoholic fatty liver disease in adult and children, in which a total of 9 clinical trial studies were included and reported significant differences in ALT, AST, and BMI between the 2 childhood groups (28).…”

Section: Discussionmentioning

confidence: 99%

The Effect of Probiotic and/or Prebiotic on Liver Function Tests in Patients with Nonalcoholic Fatty Liver Disease: A Double Blind Randomized Clinical Trial

Javadi¹,

Ghavami²,

Khoshbaten³

et al. 2017

Iran Red Crescent Med J

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Background: Oral administration of pro-and prebiotics has recently been considered as an effective way for nonalcoholic fatty liver disease (NAFLD) recovery. Objectives:The current study aimed at evaluating the effect of supplementation with probiotics and/or prebiotics on liver function tests in patients with NAFLD. Methods:In this double blind, placebo-control clinical trial, 75 subjects with NAFLD were voluntarily recruited from May 2013 to March 2014, in Iran. Participants were randomly assigned to 1 of 4 groups using a block randomization procedure. Group 1 received probiotic capsules (Bifidobacterium longum (BL) and Lactobacillus acidophilus (LA): 2 × 10 7 CFU/day), group 2 received prebiotic inulin high performance (HP): 10 g/day, group 3 received probiotic and the prebiotic, and group 4 received a placebo for 3 months. The sample size was determined on the basis of a primary outcome of a change in aspartate aminotransferase (AST) level.Results: An intergroup comparison indicated that the AST (P = 0.006) and alanine aminotransferase (ALT) (P = 0.04) levels decreased at the end of the study. Aspartate Aminotransferase (mean difference of group1 versus placebo with P value of 0.001, group2 versus placebo with P value of 0.045, group3 versus placebo with P value of 0.015) and ALT (mean difference of group 1 versus placebo with P value of 0.009, group 2 versus placebo with P value of 0.041, and group 3 versus placebo with P value of 0.046) serum levels decreased significantly in all of the intervention groups compared to the placebo. The grade of fatty liver in group 1 (P of 0.027, and number needed to treat (NNT) = 3) and group 3 (P = 0.019 and NNT = 3) decreased compared to the placebo group with no significant changes in group 2.Conclusions: Supplementation with probiotics and/or prebiotics improved aminotransferase enzymes, and supplementation with probiotics or pro-and prebiotics recovered the grade of fatty liver in NAFLD patients.

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“…Multiple studies have examined the use of probiotics alone or in conjunction with prebiotics in the treatment of NAFLD/NASH with some beneficial effects. One meta‐analysis examined 9 randomized controlled trials of probiotic use in 535 patients of NAFLD/NASH involving both adults and children; treatment duration varied from 4 weeks to 6 months . The authors found that although probiotics did not reduce body mass index, insulin, or glucose levels, there was a decrease in insulin resistance, total cholesterol, triglyceride, and tumor necrosis factor α (TNF‐α) levels.…”

Section: Gut Microbiota and Liver Diseasementioning

confidence: 99%

Microbiota and the liver

2018

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The gut microbiome outnumbers the human genome by 150-fold and plays important roles in metabolism, immune system education, tolerance development, and prevention of pathogen colonization. Dysbiosis has been associated with nonalcoholic fatty liver disease (NAFLD), nonalcoholic steatohepatitis (NASH), and alcoholic liver disease (ALD) as well as cirrhosis and complications. This article provides an overview of this relationship. Liver Transplantation 24 539-550 2018 AASLD.

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Efficacy of probiotics in non‐alcoholic fatty liver disease in adult and children: A meta‐analysis of randomized controlled trials

Cited by 86 publications

References 24 publications

Effects of long-term synbiotic supplementation in addition to lifestyle changes in children with obesity-related non-alcoholic fatty liver disease

Effects of long-term synbiotic supplementation in addition to lifestyle changes in children with obesity-related non-alcoholic fatty liver disease

The Effect of Probiotic and/or Prebiotic on Liver Function Tests in Patients with Nonalcoholic Fatty Liver Disease: A Double Blind Randomized Clinical Trial

Microbiota and the liver

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