Efficacy of preoperative versus postoperative ketorolac tromethamine 0.5% in reducing inflammation after cataract surgery

El-Harazi, Shérif M.; Ruiz, Richard; Feldman, Robert M.; Villanueva, Guillermina; Chuang, Alice Z.

doi:10.1016/s0886-3350(00)00519-8

Cited by 12 publications

(9 citation statements)

References 19 publications

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“…No statistically significant difference was evident between controls and a group that was pretreated only 1 h before surgery. Another randomized, controlled multicenter trial could not reveal a significant difference in inflammatory response between groups treated with ketorolac tromethamine 0.5% 30 min preoperation and 1 day after surgery [83]. …”

Section: Inflammation After Cataract Surgerymentioning

confidence: 99%

Topical Nonsteroidal Anti-Inflammatory Therapy in Ophthalmology

Schalnus

2003

Ophthalmologica

142

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Topically applied nonsteroidal anti-inflammatory drugs (NSAIDs) are commonly used in the management and prevention of ocular inflammation and cystoid macular edema related to cataract surgery and the maintenance of mydriasis during cataract surgery. Other common uses are the reduction of discomfort after refractive surgery or in allergic conjunctivitis. NSAIDs primarily act as cyclooxygenase inhibitors and thus reduce the formation of endogenous PGs. Today, several NSAIDs are commercially available: diclofenac, flurbiprofen, indomethacin, ketorolac and suprofen. At present the ophthalmologist has to make a decision between the use of topical corticosteroids, with their potential adverse effects, or of topical NSAIDs, with their possibly increased benefit, unknown effect on ocular pressure, wound healing and corneal tissue, higher costs and limited track record. However, the improvement of surgical techniques might support an increasing use of NSAIDs in the future. Preoperative anti-inflammatory treatment should be considered in eyes at a higher risk of developing severe postoperative inflammatory reactions. This decision has to be made carefully and has to be guided by the clinical circumstances, the spectrum of diagnosis and the individual benefit-risk ratio of each patient.

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Section: Inflammation After Cataract Surgerymentioning

confidence: 99%

Topical Nonsteroidal Anti-Inflammatory Therapy in Ophthalmology

Schalnus

2003

Ophthalmologica

142

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“…Topical nonsteroidal antiinflammatory drugs (NSAIDs) are widely used because they are effective in controlling postsurgical inflammation. [5][6][7][8] Clinical trials suggest NSAIDs are an effective alternative to steroid therapy. 1,[9][10][11][12][13] Preventing inflammation by treating with topical NSAIDs before surgery has theoretical and practical appeal.…”

mentioning

confidence: 99%

Nepafenac ophthalmic suspension 0.1% for the prevention and treatment of ocular inflammation associated with cataract surgery

Lane¹,

Modi²,

Lehmann³

et al. 2007

Journal of Cataract and Refractive Surgery

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“…2,6,7 Studies have also examined the use of other topical drugs, such as 0.1% nepafenac, 8 ketorolac, [9][10][11][12] and indomethacin, 13 in PRK or cataract surgery. 14,15 In general, these studies found the drugs to provide effective pain relief for patients.…”

Section: Discussionmentioning

confidence: 99%

Efficacy of Extended-Release Oral Diclofenac in Postoperative Pain Management After Photorefractive Keratectomy

Eslampour

Malaekeh‐Nikouei²,

Abrishami³

et al. 2013

Journal of Ocular Pharmacology and Therapeutics

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Efficacy of preoperative versus postoperative ketorolac tromethamine 0.5% in reducing inflammation after cataract surgery

Abstract: There was no difference between administering ketorolac 30 minutes preoperatively versus 1 day postoperatively in reducing inflammation.

Cited by 12 publications

References 19 publications

Topical Nonsteroidal Anti-Inflammatory Therapy in Ophthalmology

Topical Nonsteroidal Anti-Inflammatory Therapy in Ophthalmology

Nepafenac ophthalmic suspension 0.1% for the prevention and treatment of ocular inflammation associated with cataract surgery

Efficacy of Extended-Release Oral Diclofenac in Postoperative Pain Management After Photorefractive Keratectomy

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