Efficacy of preoperative ibuprofen and meloxicam on the success rate of inferior alveolar nerve block for teeth with irreversible pulpitis

Abstract

Premedication with meloxicam and ibuprofen significantly increased the success rates of inferior alveolar nerve block anaesthesia for teeth with irreversible pulpitis; however, neither drug provided profound anaesthesia.

Effect of oral premedication on the anaesthetic efficacy of inferior alveolar nerve block in patients with irreversible pulpitis – A systematic review and network meta‐analysis of randomized controlled trials

“…, Shantiaee et al . ) demonstrated low risk of bias, five studies high risk of bias (Singh et al . , Paul et al .…”

“…After full-text assessment, one study (Modaresi et al 2006) was excluded due to absent reporting of anaesthetic evaluation during access preparation. Nineteen studies (Ianiro et al 2007, Aggarwal et al 2010, Oleson et al 2010, Parirokh et al 2010, Singh et al 2010, Paul et al 2011, Prasanna et al 2011, Simpson et al 2011, Khademi et al 2012, Wali et al 2012, Jena & Shashirekha 2013, Madani et al 2013, Noguera-Gonzalez et al 2013, Shahi et al 2013, Fullmer et al 2014, Jalil et al 2014, Saha et al 2016, Mahajan et al 2017, Shantiaee et al 2017 were finally included in the systematic review and the network meta-analysis.…”

“…The quality of the 20 included studies was assessed using the Cochrane revised risk of bias guidelines as given in Table S3. Twelve studies (Ianiro et al 2007, Aggarwal et al 2010, Oleson et al 2010, Parirokh et al 2010, Prasanna et al 2011, Simpson et al 2011, Khademi et al 2012, Noguera-Gonzalez et al 2013, Shahi et al 2013, Fullmer et al 2014, Saha et al 2016, Shantiaee et al 2017) demonstrated low risk of bias, five studies high risk of bias (Singh et al 2010, Paul et al 2011, Wali et al 2012, Jena & Shashirekha 2013, Jalil et al 2014), due to bias in the randomization process and measurement of the outcome. The remaining two studies (Madani et al 2013, Mahajan et al 2017) were found to have some concerns in regard to risk of bias.…”

Effect of ibuprofen on the efficacy of inferior alveolar nerve block in patients with irreversible pulpitis: A meta‐analysis

“…Pulp was not symptomatic in most of the studies, except three studies , the pulp condition was asymptomatic. For pain evaluation, seven studies used the Heft‐Parker scale , two used a 0–100 visual analogue scale and one study used a tooth sensitivity index.…”

“…As a result, ibuprofen has been used in preventative analgesia prior to a painful stimulus. Administering ibuprofen 1 hr before anaesthetic administration has been proposed to increase the success of the inferior alveolar nerve block in patients presenting irreversible pulpitis . This recommendation is based on the fact that ibuprofen can reduce nociceptor activation by decreasing the levels of inflammatory mediators.…”