Efficacy of Preemptive oral pregabalin for prolonging post-operative analgesia in modified radical mastectomies

Sk, Prashanth Gowtham Raj; Amingad, Bhagyashree

doi:10.5958/2394-4994.2016.00066.4

Cited by 5 publications

(4 citation statements)

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“…Fifteen patients suffered from postoperative dizziness in the pregabalin group while only two patients had dizziness in the control group, this goes in accordance with results of previous studies (10,21,25,26,27) In the present study, though the incidence of postoperative nausea and vomiting (PONV) was less in patients premedicated with pregabalin (20% and 8% respectively) compared to patients in the control group (44% and 20% respectively), the difference did not reach statistical significance. This result is consistent with that of some studies (17,21,25) .The potential antiemetic effect of pregabalin is not shown in our study as the incidence of PONV was a secondary endpoint; a larger study may be needed.…”

Section: Discussionsupporting

confidence: 90%

“…The mechanism by which pregabalin attenuates haemodynamic pressor response to laryngoscopy and intubation is unknown, however, as a calcium channel modulator (3) it may be attributed to inhibition of calcium efflux from muscle cells (20) Pregabalin as a preventive analgesic that attenuates neuronal hyperexcitability and central sensitization (4) resulted in a remarkable pain relief with reduction of narcotic requirement in the immediate postoperative period. This goes in accordance with plenty of studies that proved pregabalin's antinociceptive action in relieving postoperative pain (7)(8)(9)(10)(21)(22)(23)(24)(25)(26)(27). In addition, it prolonged the duration for first rescue analgesia up to 6 h postoperatively.…”

Section: Discussionsupporting

confidence: 84%

“…In addition, it prolonged the duration for first rescue analgesia up to 6 h postoperatively. Prolongation of postoperative analgesia has been previously described (21,22,26,27). This favorable effect may be attributable to pregabalin's long elimination half-life (ranging from 5.5 to 6.7 h) 14A single dose of pregabalin 150 mg was generally well tolerated with limited side effects.…”

Section: Discussionmentioning

confidence: 87%

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Role of Preoperative Pregabalin in Reducing Inhalational Anaesthetic Requirements in Abdominal Hysterectomy: Randomized Controlled Trial

Mohamed

Ibrahim

Refai

et al. 2019

Preprint

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Background: preoperative oral pregabalin controls postoperative pain & decreases anesthetic requirements in total intravenous anaesthesia . In this study, we hypothesized that preoperative pregabalin reduces inhaled isoflurane requirements. Methods: Study was conducted in a university hospital, included 50 women (18-60 yrs.), ASA I or II, admitted to undergo elective abdominal hysterectomy under general anaesthesia. Time of study: June to September 2017. Exclusion criteria were allergy or hypersensitivity to pregabalin; patients on calcium channel blockers, antiepileptic drugs, antidepression drugs, any analgesics or sedatives, or oral hypoglycemic agents; and patients with severe cardiovascular, renal, hepatic or neurological dysfunction. Interventions: giving either oral pregabalin 150 mg or placebo to patients of both groups. Primary outcome measures: inhaled isoflurane requirements to maintain haemodynamics ± 20% of baseline& bispectral index (BIS) of 40 - 60, measured using MAQUET Flow-I anaesthetic machine. Secondary outcomes : attenuation of pressor response to intubation, postoperative pain, first time for rescue analgesia, total anaglesics and adverse effects. Results: Isoflurane consumption was significantly less in pregabalin group (7.80 ± 1.27ml h -1) versus (12.27 ± 2.49 ml h-1) in control group, (P= 0.00). Better haemodynamic stability was in pregabalin group after intubation. First postoperative hour :the mean VAS score was significantly higher in control group (7.10 ± 1.20) compared to pregabalin group (4.50 ± 1.70), P<0.001. All patients in control group received pethidine intramuscular. More patients in pregabalin group suffered dizziness. Conclusion: preoperative pregabalin 150 mg ,1 h before total abdominal hysterectomy has an inhaled anaesthetic-sparing effect, maintain haemodynamics and optimizes postoperative analgesia. Keywords: Gabapentinoids, Pregabalin; Inhalation Anaesthetics, Isoflurane; Monitoring, Bispectral Index; Surgery, Abdominal Hysterectomy Objectives: We aimed to investigate the effectiveness and safety of preoperative oral pregabalin 150 mg in women undergoing elective total abdominal hysterectomy under general anaesthesia. Design: A prospective, randomized, double-blind, controlled study. Trial Registry Number: ClinicalTrials.gov: NCT 03302208

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Section: Discussionsupporting

confidence: 90%

Section: Discussionsupporting

confidence: 84%

Section: Discussionmentioning

confidence: 87%

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Role of Preoperative Pregabalin in Reducing Inhalational Anaesthetic Requirements in Abdominal Hysterectomy: Randomized Controlled Trial

Mohamed

Ibrahim

Refai

et al. 2019

Preprint

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“…[ 28 ] In a randomized, double-blind, placebo-controlled clinical study to assess the efficacy of preemptive oral pregabalin for prolonging postoperative analgesia in modified radical mastectomy, tramadol 1 mg/kg intravenously was used as first rescue analgesic. [ 29 ]…”

Section: Discussionmentioning

confidence: 99%

A prospective, observational study to evaluate the role of gabapentin as preventive analgesic in thyroidectomy under general anesthesia

et al. 2017

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Background:Effective management of postoperative pain is a part of well-organized perioperative care, which helps in reduced morbidity and improved patient satisfaction. Preventive analgesia can reduce acute and chronic pain by blocking the noxious inputs to pain pathways, preventing sensitization. Studies have reported efficacy of gabapentin as a preventive analgesic in perioperative pain. In this study, we aimed to determine whether preoperative gabapentin reduced postoperative pain and tramadol consumption after thyroidectomy under general anesthesia.Materials and Methods:Sixty patients scheduled for thyroidectomy were allocated to two groups of thirty each for this prospective, observational study. Patients in Group A and Group B received oral gabapentin 600 mg (6 × 10−4 kg) and diazepam 10 mg (1 × 10−5 kg), respectively, 2 h prior to surgery. Tramadol was given as rescue analgesic for postoperative pain with a verbal rating score of two. The analgesic efficacy of preoperative gabapentin was assessed in terms of postoperative pain scores at rest or swallowing, time to first rescue analgesic, and total tramadol consumption for 24 h. Ramsay sedation score and side effects of drug were also looked into.Results:Postoperative pain scores and total tramadol consumption were significantly lower in Group A during 24 h (P = 0.00). Time to first rescue analgesic was significantly prolonged in Group A (P = 0.001). Side effects were comparable.Conclusion:Oral gabapentin is effective as a preventive analgesic in reducing postoperative pain and tramadol consumption after thyroidectomy under general anesthesia.

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Role of preoperative pregabalin in reducing inhalational anesthetic requirements in abdominal hysterectomy: randomized controlled trial

et al. 2020

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Efficacy of Preemptive oral pregabalin for prolonging post-operative analgesia in modified radical mastectomies

Cited by 5 publications

References 0 publications

Role of Preoperative Pregabalin in Reducing Inhalational Anaesthetic Requirements in Abdominal Hysterectomy: Randomized Controlled Trial

Role of Preoperative Pregabalin in Reducing Inhalational Anaesthetic Requirements in Abdominal Hysterectomy: Randomized Controlled Trial

A prospective, observational study to evaluate the role of gabapentin as preventive analgesic in thyroidectomy under general anesthesia

Role of preoperative pregabalin in reducing inhalational anesthetic requirements in abdominal hysterectomy: randomized controlled trial

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