Efficacy of Pre-Hospital Administration of Fibrinogen Concentrate (Clottafact®) in Trauma Patients Presumed to Bleed (FIinTIC): Results from a Multicentre Double-Blind, Placebo-Controlled, Randomised, Pilot Trial

Ziegler, Bernhard; Bachler, Mirjam; Haberfellner, H; Innerhofer, Petra; Hell, Tobias; Kaufmann, Mark; Maegele, Marc; Martini, WZ; Martinowitz, Uriel; Nebl, Caroline; Niederwanger, Christian; Oswald, Elgar; Schöchl, Herbert; Schenk, Bettina; Thaler, Markus; Treichl, Benjamin; Voelckel, Wolfgang G.; Зыкова, И. Е.; Fries, Dietmar

doi:10.2139/ssrn.3377525

Cited by 4 publications

(2 citation statements)

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“…Early fibrinogen depletion has been correlated to trauma-induced coagulopathy, and in tandem, early empiric fibrinogen repletion in trauma has been demonstrated to improve mortality. 28 29 30 31 32 33 34 35 Thus, RAR has the potential to reduce blood product waste by personalized selection of those patients who require early fibrinogen repletion with cryoprecipitate or fibrinogen concentrates. Furthermore, this study tested RAR only using human plasma, although RAR should be readily applicable for testing whole blood coagulation in principle.…”

Section: Limitationsmentioning

confidence: 99%

Resonant Acoustic Rheometry to Measure Coagulation Kinetics in Hemophilia A and Healthy Plasma: A Novel Viscoelastic Method

Hobson

Bunch

et al. 2022

Semin Thromb Hemost

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Compared with conventional coagulation tests and factor-specific assays, viscoelastic hemostatic assays (VHAs) can provide a more thorough evaluation of clot formation and lysis but have several limitations including clot deformation. In this proof-of-concept study, we test a noncontact technique, termed resonant acoustic rheometry (RAR), for measuring the kinetics of human plasma coagulation. Specifically, RAR utilizes a dual-mode ultrasound technique to induce and detect surface oscillation of blood samples without direct physical contact and measures the resonant frequency of the surface oscillation over time, which is reflective of the viscoelasticity of the sample. Analysis of RAR results of normal plasma allowed defining a set of parameters for quantifying coagulation. RAR detected a flat-line tracing of resonant frequency in hemophilia A plasma that was corrected with the addition of tissue factor. Our RAR results captured the kinetics of plasma coagulation and the newly defined RAR parameters correlated with increasing tissue factor concentration in both healthy and hemophilia A plasma. These findings demonstrate the feasibility of RAR as a novel approach for VHA, providing the foundation for future studies to compare RAR parameters to conventional coagulation tests, factor-specific assays, and VHA parameters.

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Section: Limitationsmentioning

confidence: 99%

Resonant Acoustic Rheometry to Measure Coagulation Kinetics in Hemophilia A and Healthy Plasma: A Novel Viscoelastic Method

Hobson

Bunch

et al. 2022

Semin Thromb Hemost

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“…Accordingly, the Canadian Armed Forces adopted FC (RiaSTAP, CSL Behring) for damage control resuscitation in the far-forward combat setting [36]. Moreover, a prospective, randomized, placebo-controlled, doubleblinded trial demonstrated that prehospital administration of FC (Clottafact, LFB France) is feasible, protects against early fibrinogen depletion and promotes rapid blood clot initiation and clot stability in trauma patients [95].…”

Section: Fibrinogen Concentratementioning

confidence: 99%

Hemostatic agents for prehospital hemorrhage control: a narrative review

Peng

2020

Military Med Res

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Hemorrhage is the leading cause of preventable death in combat trauma and the secondary cause of death in civilian trauma. A significant number of deaths due to hemorrhage occur before and in the first hour after hospital arrival. A literature search was performed through PubMed, Scopus, and Institute of Scientific Information databases for English language articles using terms relating to hemostatic agents, prehospital, battlefield or combat dressings, and prehospital hemostatic resuscitation, followed by cross-reference searching. Abstracts were screened to determine relevance and whether appropriate further review of the original articles was warranted. Based on these findings, this paper provides a review of a variety of hemostatic agents ranging from clinically approved products for human use to newly developed concepts with great potential for use in prehospital settings. These hemostatic agents can be administered either systemically or locally to stop bleeding through different mechanisms of action. Comparisons of current hemostatic products and further directions for prehospital hemorrhage control are also discussed.

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Viscoelastic Hemostatic Tests and Fibrinogen Concentrations in Trauma

Peng

Beckett

2022

Biomarkers in Trauma, Injury and Critical Care

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Efficacy of Pre-Hospital Administration of Fibrinogen Concentrate (Clottafact®) in Trauma Patients Presumed to Bleed (FIinTIC): Results from a Multicentre Double-Blind, Placebo-Controlled, Randomised, Pilot Trial

Cited by 4 publications

References 0 publications

Resonant Acoustic Rheometry to Measure Coagulation Kinetics in Hemophilia A and Healthy Plasma: A Novel Viscoelastic Method

Resonant Acoustic Rheometry to Measure Coagulation Kinetics in Hemophilia A and Healthy Plasma: A Novel Viscoelastic Method

Hemostatic agents for prehospital hemorrhage control: a narrative review

Viscoelastic Hemostatic Tests and Fibrinogen Concentrations in Trauma

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