Efficacy of postbiotics against free radicals and UV radiation

Ácsová, Aneta; Hojerová, Jarmila; Martiniaková, Silvia

doi:10.1007/s11696-021-02018-7

Cited by 7 publications

(5 citation statements)

References 43 publications

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“…The antioxidant potential of tested substances was investigated for the scavenging activity of DPPH radicals [32] with slight modification for determination in a cuvette spectrophotometer. Both postbiotics were evaluated (i) as a 30, 50, 60, 70, and 80% (v/v) aqueous solution or (ii) as a gel with incorporated postbiotics in the same concentration as solutions.…”

Section: Determination Of Dpph Radical Scavenging Activity (In Gel/in...mentioning

confidence: 99%

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Low-Molecular-Weight Gels as Smart Materials for the Enhancement of Antioxidants Activity

et al. 2023

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Antioxidants are important substances used in the cosmetic and pharmaceutical fields that are able to block free radicals. These compounds can be incorporated into formulations for many reasons, such as release over time or preservation of the formulation activity and applicability. In the present study, a low-molecular-weight gel made with Boc-L-DOPA(Bn)2-OH was studied as suitable material to host antioxidants and improve their activity. The solvent change (DMSO/H2O) in combination with temperature was the technological procedure for the preparation of the gel. Two different antioxidants were tested: (1) α-tocopherol and (2) postbiotics. The antioxidant activity of α-tocopherol and of the postbiotics in the gel, measured by the (2,2-diphenyl-1-picryl-hydrazyl radical (DPPH) assay, showed higher values than those in the pure solvent. The antioxidant activity of the gel with 0.8 w/v% of gelator and α-tocopherol in the concentration range of 5–100 µM was 2.7–1.1 times higher on average than in the pure solvent. In the case of both postbiotics, the biggest difference was observed at 30% of postbiotics in the gel with 0.5% of a gelator, when the antioxidant activity was 4.4 to 4.7 times higher than that in the pure solvent.

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Section: Determination Of Dpph Radical Scavenging Activity (In Gel/in...mentioning

confidence: 99%

“…Therefore, when it comes to cosmetics, products contain extracts, lysates, or products of the fermentation process made from bacteria (referred to as postbiotics) rather than living cultures (probiotics). The antioxidant activity of postbiotics has been documented by Feng and Wang [31] or Ácsová et al [32].…”

Section: Introductionmentioning

confidence: 96%

Low-Molecular-Weight Gels as Smart Materials for the Enhancement of Antioxidants Activity

et al. 2023

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“…In a recent clinical trial, it was found that a topical product containing gel‐based BFL was safe and effective in the treatment of mild or moderate acne 23 . In addition, an in vitro study showed that a mixed formulation containing BFL could protect skin from free radicals 24 . In view of the potential results revealed by existing tests, none of the effects of BFL on skin health has been comprehensively and widely discussed, it is necessary to carry out further research.…”

Section: Introductionmentioning

confidence: 99%

“…23 In addition, an in vitro study showed that a mixed formulation containing BFL could protect skin from free radicals. 24 In view of the potential results revealed by existing tests, none of the effects of BFL on skin health has been comprehensively and widely discussed, it is necessary to carry out further research. In this study, a BFL isolated from Bifidobacterium was used, and its beneficial impact on skin was studied in vitro.…”

Section: Introductionmentioning

confidence: 99%

The pivotal role of Bifida Ferment Lysate on reinforcing the skin barrier function and maintaining homeostasis of skin defenses in vitro

Wang,

Yan,

et al. 2023

J of Cosmetic Dermatology

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BackgroundThe semiactive or inactive probiotics or their extracts used in dermatology have interesting properties to ameliorate signs of irritated skin and enhance the skin barrier. Bifidobacterium, as the most common probiotics, which has been found to be effective in reducing acne and improving the skin barrier function of atopic dermatitis. Bifida Ferment Lysate (BFL) can be obtained from Bifidobacterium by fermentation and extraction.PurposeIn this study, we investigated the effect of a topically used BFL on the skin using in vitro evaluation methods.ResultsThe results showed that upregulation of skin physical barrier gene (FLG, LOR, IVL, TGM1, and AQP3) and antimicrobial peptide gene (CAMP and hBD‐2) in HaCaT cells by BFL might be responsible for skin barrier resistance. In addition, BFL had strong antioxidant properties representing a dose‐dependent increasing of the scavenging capacity of DPPH, ABTS, hydroxyl, and superoxide radicals. BFL treatment also fundamentally inhibited the intracellular ROS and MDA production and improved the activities of antioxidant enzymes (CAT and GSH‐Px) in H2O2‐stimulated HaCaT cells. As a good immunomodulatory factor, BFL efficiently decreased the secretion of IL‐8 and TNF‐α cytokines, and COX‐2 mRNA expression in LPS‐induced THP‐1 macrophages.ConclusionBFL can strengthen the skin barrier function and stimulate skin barrier resistance, to reinforce the skin against oxidative stress and inflammatory stimuli.

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“…Recent studies suggest that some postbiotics can scavenge free radicals to reduce skin damage [15][16][17]; furthermore, they can naturally balance the skin microbiota [18]. Considering all these properties, postbiotic potentialities in the cosmetic field are evident.…”

Section: Introductionmentioning

confidence: 99%

Functional Properties of an Oat-Based Postbiotic Aimed at a Potential Cosmetic Formulation

Lentini

Nigro²,

Cante

et al. 2022

Fermentation

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The concept of postbiotic has been attracting the attention of the scientific community and several industrial realities to develop new claims and new market segments for functional fermented products. The aim of this work was to develop a process to produce an oat-based postbiotic ingredient to be used in personal care cosmetic formulations. A hydrolyzed oatmeal suspension was fermented using Lacticaseibacillus paracasei CBA L74 as starter culture, at 37 °C for 48 h by controlling the pH; then the bacterial charge was inactivated by a mild thermal treatment at 80 °C for 30 s, obtaining a postbiotic. The effect of different process steps, hydrolysis, sterilization, fermentation, and inactivation phases, on lactic acid concentration, total polyphenolic content, antioxidant activity, tyrosinase inhibition activity and Sun Protection Factor value was investigated, demonstrating the potential cosmetic applications. The maximum bacterial growth and lactic acid production were achieved after 24 h of process, with a cell density and a lactic acid concentration of 3.05 × 109 CFU/mL and 8.60 g/L, respectively. The total phenolic content and the antioxidant activity reached their maximum values (2.5 mgGAE/mL, EC50 = 2.2 mg/mL and 1.38 × 10−2 mmol Fe2+/g and 7.3 × 10−3 mmol TE/g, respectively) after the sterilization treatment; the maximum tyrosinase inhibition of 50.6%, corresponding to a sample concentration of 16 mg/mL, was found after 24 h of fermentation process. Fermentation did not show an impact on UV shielding ability and the SPF value decreased during the process.

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Efficacy of postbiotics against free radicals and UV radiation

Cited by 7 publications

References 43 publications

Low-Molecular-Weight Gels as Smart Materials for the Enhancement of Antioxidants Activity

Low-Molecular-Weight Gels as Smart Materials for the Enhancement of Antioxidants Activity

The pivotal role of Bifida Ferment Lysate on reinforcing the skin barrier function and maintaining homeostasis of skin defenses in vitro

Functional Properties of an Oat-Based Postbiotic Aimed at a Potential Cosmetic Formulation

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