Efficacy of Pneumococcal Polysaccharide Vaccine in Preventing Acute Otitis Media in Infants in Huntsville, Alabama

Nasopharyngeal pathogens in children with acute otitis media in a low-antibiotic use country

“…Resistance was infrequent in all species, which matches up to earlier findings in other Danish studies [10,11]. Serotypes of S. pneumoniae found in this study correlate to respective findings in other countries, with accumulation of serotypes 6A, 6B, 11A, 14, 19F, and 23F [1,12,13].…”

Safety and immunogenicity of the 23-valent pneumococcal polysaccharide vaccine at 12 months of age, following one, two, or three doses of the 7-valent pneumococcal conjugate vaccine in infancy

“…In contrast, pneumococcal polysaccharide vaccines have shown no effect on pneumococcal carriage [20-24]. Most studies evaluating the impact of pneumococcal polysaccharide immunization in the absence of additional PCV-7 in infants or children have not shown any impact on pneumococcal disease or carriage [25-27]. This finding may be at least partially explained by the lack of effect that pneumococcal polysaccharide vaccine has on NP carriage.…”

Influenza Vaccination in the Prevention of Acute Otitis Media in Children

“…4 The results of extensive vaccine trials against the most common causative agent, Strepto¬ coccus pneumoniae, have not so far been very satisfying. [5][6][7][8] Clinical evidence has shown that in most cases AOM is preceded by a respiratory viral infection.9 A simultaneous viral infection has been documented in 26% to 42% of pa¬ tients with AOM.10-14 The greatest risk for the develop¬ ment of AOM lies in infections caused by respiratory syncytial viruses (RSVs), rhinoviruses, influenza A viruses, or adenoviruses. 11-14'15 Our study was based on the hypothesis that prevention of the preceding respiratory viral infection would decrease the incidence of AOM.…”