Efficacy of Platelet Rich Plasma and Hydroxyapatite Crystals in Bone Regeneration After Surgical Removal of Mandibular Third Molars

Kaur, Preeti; Maria, Anisha

doi:10.1007/s12663-012-0382-6

Cited by 20 publications

(10 citation statements)

References 19 publications

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“…The PRPs were already tested in many oral surgery applications, with mixed results depending on the kind of preparations [ 13 – 16 ]. Numerous protocols have attempted to optimize the preparation of the autologous factors, using various performances standards and centrifugation parameters [ 17 , 18 ].…”

Section: Introductionmentioning

confidence: 99%

Influence of Leukocyte- and Platelet-Rich Fibrin (L-PRF) in the Healing of Simple Postextraction Sockets: A Split-Mouth Study

Marenzi

Riccitiello

Tia³

et al. 2015

BioMed Research International

102

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The aim of this study was to evaluate the effects of leukocyte- and platelet-rich fibrin (L-PRF) on the pain and soft tissue healing after tooth extractions. Twenty-six patients (9 males and 17 females) were treated with multiple extractions (2 to 8), with a total of 108 extractions. This was an exploratory single blinded randomized clinical trial with a split-mouth design. The pain after the surgery was assessed in each patient by the VAS scale (1 to 10) at intervals of 24-48-72-96 hours. The soft tissue healing was clinically evaluated at 3, 7, 14, and 21 days after surgery by the same examiner surgeon, using the modified Healing Index (4 to 12). The mean value of postextraction pain was 3.2 ± 0.3 in the experimental sides and 4.1 ± 0.1 in the control sides. After 7 days from the extractions, the values of modified Healing Index in the experimental and control groups were, respectively, 4.8 ± 0.6 and 5.1 ± 0.9. The use of L-PRF in postextraction sockets filling can be proposed as a useful procedure in order to manage the postoperative pain and to promote the soft tissue healing process, reducing the early adverse effects of the inflammation.

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Section: Introductionmentioning

confidence: 99%

Influence of Leukocyte- and Platelet-Rich Fibrin (L-PRF) in the Healing of Simple Postextraction Sockets: A Split-Mouth Study

Marenzi

Riccitiello

Tia³

et al. 2015

BioMed Research International

102

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“…They recommended the placement of resorbable membranes to prevent periodontal defects. Another study described the use of HA particles and PRP in comparison with control sites: an improvement in wound healing and increase in bone density were observed in the study group; however, the parameters were not significant [ 33 ]. Barbato et al (2015) [ 34 ] found in a systematic review that periodontal healing following extraction of M3M may benefit from GTR-based procedures compared to nongrafting procedures; however, an overall low quality of evidence was found.…”

Section: Discussionmentioning

confidence: 99%

Hard Tissue Preservation in Minimally Invasive Mandibular Third Molar Surgery Using In Situ Hardening TCP Bone Filler

Engelke

Lazzarini

Beltrán

2018

BioMed Research International

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Background Maintenance of hard tissue in the case of impacted third molars (M3M) with close relationship to the mandibular canal is still a surgical challenge which may be overcome using the inward fragmentation technique. Methods A consecutive case series of 12 patients required the extraction of 13 impacted M3M with a close relationship to the inferior alveolar nerve (IAN). Via occlusal miniflaps, M3M were exposed occlusal under endoscopic vision and removed by inward fragmentation. All patients received socket preservation with resorbable in situ hardening TCP particles to reduce the risk of pocket formation at the second molar. Results All 13 sites healed uneventfully. Bone height was assessed using CBCT cross-sectional reformats pre- and 3 months postoperatively. The bone height was reduced by 1.54 mm lingual (SD 0.88), 2.91 mm central (SD 0.93), and 2.08 mm buccal (SD 1.09). Differences were significant at a 0.05% level. No tissue invagination at the extraction sites was observed. Conclusions Major bone defects can be avoided safely using inward fragmentation surgery. The self-hardening bone filler appears to enhance the mineralization of the intrabony defect.

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“…PRP is an autologous product that contains highly concentrated number of platelet in a small volume of plasma from whole blood by gradient density centrifugation. It is a proven source of growth factors like platelet-derived growth factor (PGDF) and transforming growth factor β1 and β2 (TGF-β1 and β2), which is obtained by sequestering and concentrating platelets by gradient density centrifugation [25,47]. This substrate is considered to ameliorate tissue regeneration due to presence of essential various cytokines and growth factors (GFs).…”

Section: Platelet-rich Plasma (Prp)mentioning

confidence: 99%

Biomaterials for Tissue Engineering Applications in Diabetes Mellitus

Gomes¹,

Amorim²,

ChrystianeGiannasi³

et al. 2018

Biomaterials in Regenerative Medicine

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The search for ideal implants or alternative scaffolds is a challenge for biomedical science researchers, especially in diabetic patients. Many alternative bioactive materials have been used in the regenerative medicine, especially in patient with complex metabolic disorder as diabetes mellitus. Among them, we discussed the following alternative material scaffolds, including amniotic membrane (AM), homogenous demineralized dentin matrix (HDDM), platelet-rich plasma (PRP), and alloplastic materials as porous polyethylene and polyurethane. These biomaterials were applied in the craniomaxillofacial complex and liver injury, resulting in tissue regeneration and microstructural reconstruction due to their effective inductive and conductive properties. Additionally, diabetes disease and its general biophysical mechanism and systemic complications were described in order to improve the comprehension of the physiopathology of this comorbidity and its effects in the tissues. The AM, HDDM, and PRP in implantation sites initiated an inductive cascade as chemotaxis of progenitor cells, mitogenesis, angiogenesis, and differentiation into wide variety of cells. The cell recruitment, division rate, and differentiation of cell lines are under the direct control of several growth factors and stem cells which are present in these biomaterials. Further, some alloplastic materials have triggered satisfactory tissue responses when used in treatments of craniofacial deformities or in anatomical reconstructions.

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Efficacy of Platelet Rich Plasma and Hydroxyapatite Crystals in Bone Regeneration After Surgical Removal of Mandibular Third Molars

Cited by 20 publications

References 19 publications

Influence of Leukocyte- and Platelet-Rich Fibrin (L-PRF) in the Healing of Simple Postextraction Sockets: A Split-Mouth Study

Influence of Leukocyte- and Platelet-Rich Fibrin (L-PRF) in the Healing of Simple Postextraction Sockets: A Split-Mouth Study

Hard Tissue Preservation in Minimally Invasive Mandibular Third Molar Surgery Using In Situ Hardening TCP Bone Filler

Biomaterials for Tissue Engineering Applications in Diabetes Mellitus

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